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Original Article
Efficacy of imatinib mesylate-based front-line therapy in pediatric chronic myelogenous leukemia
Hyun Jin Oh, Mun Sung Cho, Jae Wook Lee, Pil-Sang Jang, Nack-Gyun Chung, Bin Cho, Hack-Ki Kim
Clin Exp Pediatr. 2013;56(8):343-350.   Published online August 27, 2013
Purpose

Despite the established role of imatinib (IM) in chronic myelogenous leukemia (CML) in adults, there are few reports on its efficacy in children. In this study, we compared the outcomes of children with CML before and after the advent of IM-based treatment.

Methods

The study cohort consisted of 52 patients treated for CML at the Department of Pediatrics, The Catholic University of...

Review Article
The treatment of pediatric chronic myelogenous leukemia in the imatinib era
Jae Wook Lee, Nack Gyun Chung
Clin Exp Pediatr. 2011;54(3):111-116.   Published online March 31, 2011

Childhood chronic myelogenous leukemia (CML) is a rare hematologic disease, with limited literature on the methods of treatment. Previously, allogeneic hematopoietic stem cell transplantation (HSCT) was considered the only curative treatment for this disease. Treatment with imatinib, a selective inhibitor of the BCR-ABL tyrosine kinase (TKI), has resulted in prolonged molecular response with limited drug toxicity. Imatinib is now implemented...

Original Article
A Case of Juvenile Chronic Myelogenous Leukemia Associated with Juvenile Xanthogranuloma.
Eun Yong Lee, Jin Tae Kim, Young Sook Hong, Soon Kyun Kim, Hyun Keum Lee
Clin Exp Pediatr. 1987;30(11):1299-1304.   Published online November 30, 1987
We experienced a case of juvenile chronic myelogenous leukemia associated with juvenile xanthogranuloma and neurofibromatosis. This 1-year 6-month-old male patient had multipe cafg-au-lait spots, numerous nontender, yellowish, dome-shaped papules and nodules, hepatosplenomegaly, and pneumonia. Hematologic & bone marrow examinations, chromosomal study, and skin biopsy were performed for diagnosis. A brief review of the related literatures was added.
Case Report
A Case of Chronic Myelogenous Leukemia in a Child Treated in a Interferon.
Ill Soo Ha, Jon Lin Rhi, Se Jung Sohn, Dug Ha Kim, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1986;29(11):1232-1238.   Published online November 30, 1986
A child with Ph^positive chronic myelogenous leukemia was treated with human leukocyte interferon (Hu IFN-alpha). Hematologic remission was obtained in 16 weeks of treatment, and white blood cell count was decreased in number from 115,000 to 9,600. Platelet：count, spleen size, LDH and bone marrow M/E ratio were decreased in parallel, but there was no significant change in serum vitamin B12...