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Original Article
Immunology
Immunogenicity and safety of a 12-valent pneumococcal conjugate vaccine in infants aged 6–10 weeks: a randomized double-blind active-controlled trial
Jonghoon Shin, Jamaree Teeratakulpisarn, Thanyawee Puthanakit, Tuangtip Theerawit, Ji Hwa Ryu, Jinhwan Shin, Seulgi Lee, Hayoung Lee, Kyungjun An, Hun Kim
Clin Exp Pediatr. 2020;63(7):265-271.   Published online December 6, 2019
Question: The immunogenicity and safety of GBP411 when administered to healthy infants are not understood.
Finding: The intergroup differences were not significant for all 12 serotypes after the booster dose. The overall incidence of solicited local adverse events between the groups did not differ significantly.
Meaning: GBP411 with a 2p+1 dosing schedule induced a substantial immune response, and may be safe for administration to healthy infants.
Detection of nasopharyngeal carriages in children by multiplex reverse transcriptase-polymerase chain reaction
Ji Hye Shin, Hye Young Han, Sun Young Kim
Clin Exp Pediatr. 2009;52(12):1358-1363.   Published online December 15, 2009
Purpose : The aim of this study was to determine the prevalence of asymptomatic nasopharyngeal carriages in children using a multiplex reverse transcriptase-polymerase chain reaction (mRT-PCR) assay kit. Methods : We obtained nasopharyngeal swabs from 33 children without any underlying disease from July 25 to July 28, 2008. The children were free from the signs of respiratory tract infections at the...
Review Article
Antibiotics for bacterial pneumonia in children
Hye-yung Yum
Clin Exp Pediatr. 2009;52(3):283-288.   Published online March 15, 2009
Pneumonia remains the leading cause of mortality in children. Diagnosis depends on a combination of factors, including clinical assessment, radiological and laboratory findings. Although Streptococcus pneumoniae remains the most important cause of childhood bacterial pneumonia, the great majority of cases of community-acquired pneumonia (CAP) are of viral etiology. A new, rapid, and inexpensive test that differentiates viral from bacterial pneumonia...
Original Article
Bacterial meningitis in children experienced at a university hospital, 1993-2006
Sung Yoon Cho, Tae Yeon Kim, Hyunju Lee, Kyung Hyo Kim, Eun Sun Yoo, Hae Soon Kim, Eun Ae Park, Kyung Ha Ryu, Jeong Wan Seo, Sejung Sohn, Seung Joo Lee
Clin Exp Pediatr. 2008;51(10):1077-1084.   Published online October 15, 2008
Purpose : Despite the seriousness of bacterial meningitis in children, there is little information on the incidence, causative organisms, mortality rate and age distribution. We studied the frequency by age group and causal pathogens, and clinical characteristics in children with bacterial meningitis in the private sector in Korea. Methods : The medical records containing the data on bacterial meningitis patients...
Review Article
Emergence of macrolide resistance and clinical use of macrolide antimicrobials in children
Eun Hwa Choi
Clin Exp Pediatr. 2008;51(10):1031-1037.   Published online October 15, 2008
Macrolide antimicrobial agents including erythromycin, roxithromycin, clarithromycin, and azithromycin are commonly used in the treatment of respiratory tract infections in children. Newer macrolides that have structural modifications of older drug erythromycin show improved change in the spectrum of activity, dosing, and administration. However, recent studies reported that increasing use of macrolide antibiotics is the main force driving the development of...
The management of sinusitis in children
Manyong Han
Clin Exp Pediatr. 2007;50(4):328-334.   Published online April 15, 2007
Sinusitis is a common medical problem in children. The prevalence of penicillin-resistant S. pneumoniae infection has been increased during the last decade. The medical management is based on the choice of antimicrobial agents. This article reviews current literatures on the management of acute bacterial sinusitis and chronic sinusitis, with an emphasis on penicillin-resistant S. pneumoniae infection. This article also explores...
Original Article
A clinical study of child bacterial meningitis in Daejeon and Chungcheong area : 2001-2005
Yong Joo Lee, Soo Jin Lee, Ho Jin Park, Young Hyuk Lee, So Young Kang, Young Chang Kim, In Kyu Lee, Kyung Yeon Lee, Keon Su Lee, Won Seop Kim
Clin Exp Pediatr. 2007;50(2):157-162.   Published online February 15, 2007
Purpose : The purpose of this study was to analyze the epidemiology, causative organism, clinical manifestation and prognosis of bacterial meningitis for children after the introduction of Haemophilus influenzae type b (Hib) vaccine in Daejeon and Chungcheong area. Methods : We analyzed retrospectively 53 medical records who had been diagnosed with bacterial meningitis at 10 general or university hospitals...
A study of serotyping of Streptococcus pneumoniae by multibead assay
Ky Young Cho, Jung Ah Lee, Sung Eun Cho, Nam Hee Kim, Jin A Lee, Ki Sook Hong, Hoan Jong Lee, Kyung Hyo Kim
Clin Exp Pediatr. 2007;50(2):151-156.   Published online February 15, 2007
Purpose : Streptococcus pneumoniae is a major etiologic agent for pneumonia, meningitis, otitis media, and sepsis among young children. Multi-drug resistant strains have raised great concern worldwide, thus the importance of prevention with vaccines has been emphasized. However, vaccines may force the appearance of pneumococcal infections by nonvaccine serotypes. Thus, distribution of pneumococcal serotypes should be monitored to estimate vaccine...
Pneumococcal Surface Protein A of Streptococcus pneumoniae Isolates from Koreans
Kyung Hyo Kim
Clin Exp Pediatr. 2005;48(11):1206-1211.   Published online November 15, 2005
Purpose : Pneumococcal protein vaccine based on pneumococcal surface protein A (PspA) is in development with the potential to offer a broad range of protection against different strains. PspA elicits protection in mice against fatal sepsis as well as carriage and lung infection. This study was performed to investigate the frequency of PspA families among Streptococcus pneumoniae recovered from Korean...
Clinical Entities and Etiology of Invasive Bacterial Infections in Apparently Healthy Children
Joon Ho Lee, Eun Kyoung Song, Jin A Lee, Nam Hee Kim, Dong Ho Kim, Ki Won Park, Eun Hwa Choi, Hoan Jong Lee
Clin Exp Pediatr. 2005;48(11):1193-1200.   Published online November 15, 2005
ilus influenzae has been declined to 4% each from 23% and 14%, respectively, compared to previous study. S. agalactiae was the most common isolate in the infants ≤3 months. Among the infants and children aged 3 months to 2 years and children of 2-5 years, S. pneumoniae(57%, 52%, respectively, in each group) was the most common isolates followed by S....
Functional Immunity to Cross-Reactive Serotype 6A Induced by Serotype 6B in Pneumococcal Polysaccharide Vaccine
Kyung Hyo Kim
Clin Exp Pediatr. 2005;48(5):506-511.   Published online May 15, 2005
Purpose : Streptococcus pneumoniae serotype 6B and 6A are important pathogens in pneumococcal infections. It is commonly assumed that the 6B vaccines elicit antibodies cross-reacting with the 6A serotype and the cross-reactive antibodies protect against infections of 6A. To examine this assumption, we measured the opsonophagocytic capacity to serotype 6A and 6B in adults. Methods : Twenty-four adults were immunized...
Penicillin Resistant Distribution and in-vitro Susceptibility of Oral Antibiotics against Streptococcus pneumoniae, isolated from Pediatric Patients with Community- Acquired Respiratory Infections in Korea
Jin Han Kang, Sun Mi Kim, Jong Hyun Kim, Hur Jae Kyun, Kyung Yil Lee, Young Ku Shin, Su Eun Park, Sang Hyuk Ma, Young Jin Hong
Clin Exp Pediatr. 2005;48(1):40-47.   Published online January 15, 2005
Purpose : S. pneumoniae is one of major pathogens of community-acquired respiratory infections. The rate of antibiotic resistance to this organism has increased, and resistance to multiple antimicrobial agents in a single strain of S. pneumoniae may compromise the efficacy of empiric antimicrobial treatment commonly used for respiratory infections. We did this study to find out the penicillin resistant distributions...
Functional Antibody Responses to Seven Serotypes in Pneumococcal Polysaccharide Vaccine in Children
Ji Hye Park, Hee Jung Kim, Young Mi Hong, Kyung Hyo Kim
Clin Exp Pediatr. 2004;47(11):1173-1180.   Published online November 15, 2004
Purpose : Streptococcus pneumoniae is an important pathogen in children as well as in elderly people. The aim of this study was to assess the opsonization activity of pneumococal capsular antibody to seven serotypes in 23-valent pneumococcal polysaccharide vaccine before and after immunization in Korean children. Methods : Nine children from 24 to 49 months of age were immunized with 23-valent...
Case Report
A Case of Multiple Septic Arthritis by Streptococcus pneumoniae in Kawasaki Disease
Jae-Hoon Choe, In-Gyu Lee, Kyung-Bae Park, Joon-Soo Park, Young Chang Kim, Hwa-Yong Song, Byung-Heum Kim
Clin Exp Pediatr. 2004;47(5):579-582.   Published online May 15, 2004
In Kawasaki disease, arthritis may occur, generally affecting the hands, knees, ankles, or hips. Operations have not usually been needed. We report a case of Kawasaki Disease with multiple septic arthritis which was caused by S. pneumoniae and which needed athrotomy with drainage for both hips, both knees, and both ankle joints. A two year, ten-month-old girl was admitted to...
Atypical Hemolytic Uremic Syndrome Associated with Streptococcus pneumoniae Infection
Hyun Sug Lee, Ja Wook Koo, Sang Woo Kim, Hyun Soon Lee
Clin Exp Pediatr. 2004;47(2):217-222.   Published online February 15, 2004
Hemolytic uremic syndrome is the most common cause of acute renal failure in childhood. Atypical hemolytic uremic syndrome which is not usually associated with prodromal symptoms has a higher mortality rate and more tendency to progress to chronic renal failure. Children younger than two years of age are a more susceptible to pneumococcal infection and can develop more serious disease....
Original Article
Serotypes and Penicillin Susceptibility of Streptococcus pneumoniae Isolated from Clinical Specimens and Healthy Carriers of Korean Children
Jin-A Lee, Nam-Hee Kim, Dong-Ho Kim, Ki-Won Park, Yun-Kyung Kim, Kyoung-Hyo Kim, Jin-Young Park, Eun-Hwa Choi, Hoan-Jong Lee
Clin Exp Pediatr. 2003;46(9):846-853.   Published online September 15, 2003
Purpose : Pneumoccocus is one of the most important causes of invasive infection through the childhood period and the prevelance of antibiotics resistance of pneumococcus is increasing worldwide. A 7-valent conjugate vaccine has been developed. It is important to know the prevalence of each serotype of pneumococci in the countries where the vaccine is used to estimate the coverage rate...
Treatment Outcome of Penicillin-resistant S. Pneumoniae Infection
Min Sook Choi, Young Won Kim, Dong Soo Kim, Kyung Won Lee
Clin Exp Pediatr. 2001;44(2):149-153.   Published online February 15, 2001
Purpose : Streptococcus pneumoniae is a normal flora and common pathogen of the upper respiratory tract. S. pneumoniae infections are estimated to cause not only localized infection such as pneumonia, and otitis media, but also systemic infections, for example meningitis, sepsis, and so on. Recently, the resistance of S. pneumoniae to penicillin and multidrug has been rapidly increasing in many...
Case Report
A Case of Newborn Sepsis Caused by Streptococcus pneumoniae
Eun Ha Choi, Seong Hee Jang, Eun Sil Dong, Young Min Ann
Clin Exp Pediatr. 1995;38(12):1690-1693.   Published online December 15, 1995
Systemic infection due to Streptococcus pneumoniae is a serious, albeit rare disease in the neonatal period. There is no case of pneumococcal sepsis reported in Korea. The results of epidemiologic studies suggest that the majority of infants with pneumococcal septicemia acquire the microorganisms either by the ascending route or during passage throught the birth canal. The mortality is high in...