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Review Article

Mammalian target of rapamycin inhibitors for treatment in tuberous sclerosis

Won Seop Kim

Clin Exp Pediatr. 2011;54(6):241-245. Published online June 30, 2011

Tuberous sclerosis complex (TSC) is a genetic multisystem disorder that results from mutations in the TSC1 or TSC2 genes, and is associated with hamartomas in several organs, including subependymal giant cell tumors. The neurological manifestations of TSC are particularly challenging and include infantile spasms, intractable epilepsy, cognitive disabilities, and autism. The TSC1- and TSC2-encoded proteins modulate cell function via the...

DOI: https://doi.org/10.3345/kjp.2011.54.6.241

Case Report

A Case of Tuberous Sclerosis Complex Developing with Subependymal Giant-Cell Astrocytoma and Hydrocephalus

Ki Hyun Chung, Wan Sub Kim

Clin Exp Pediatr. 1996;39(2):280-286. Published online February 15, 1996

The subependymal giant-cell astrocytoma, a key feature of the tuberous sclerosis complex, has been reported in patients without obvious features of this condition. The tumor is a rare cerebral glioma that characteristically arise in the wall of lateral ventricle and as an intraventricular mass, causing hydrocephalus by obstruction of the foramen of Monro. We experienced a case of tuberous sclerosis...

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