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Original Article
Clinical Characteristics of Complex Partial Seizures : a Temporal versus a Frontal Lobe Onset
Joon Soo Lee, Jae Hyun Park, Chang Jun Coe
Clin Exp Pediatr. 1998;41(6):769-774.   Published online June 15, 1998
Purpose : This study was performed to correlate clinical behaviours with either a temporal or frontal site of origin and then to identify behaviours that might have a significant practical value in differentiating a temporal from a frontal focus and thus reduce the need for invasive monitoring. Methods : We analysed 129 seizures that occured during video-EEG monitoring in 13 patients with temporal lobe epilepsy(TLE)...
Tc-99m HMPAO Brain SPECT in a Patient with Neonatal Seizure and Right Cerebral Hemiatrophy
Hye Young Kang, Kook In Park, Ran Namgung, Chul Lee, Chang Jun Coe, Dong Gwan Han, Tae Sub Chung, Woo Hee Jung
Clin Exp Pediatr. 1994;37(3):397-404.   Published online March 15, 1994
Functional brain imaging is very important in the diagnosis and evaluation of the various neurologic disorders. In addition to electroencephalography (EEG) and positron emission tomography (PET), single photon emission computed tomography (SPECT) have increasingly gained importance in determination of disturbances in regional brain functions. Both ictal and interictal Tc-99m hexamethyl-propyleneamine oxime single photon emission computed tomography (Tc-99m HMPAO SPECT) was done...
Neonatal hypocalcemia: clinical manifestations and prognosis.
Jeong Lim Kim, Heung Dong Kim, Chang Jun Coe
Clin Exp Pediatr. 1991;34(7):912-920.   Published online July 31, 1991
Hypocalcemia during the newborn period is relatively common particularly in infants with predis- posing factors, such as prematurity, low birth weight, birth asphyxia and diabetic mothers and it is often manifested by various clinical findings. Some authors have reported that in some cases of the neonatal hypocalcemia, there were neurologic deficits such as irritability and convulsion, and neur- ologic sequelae on follow up. It...
Mannitol induced acute oliguric renal failure.
Young Mi Chung, Jae Seung Lee, Chang Jun Coe
Clin Exp Pediatr. 1991;34(6):857-862.   Published online June 30, 1991
Mannitol known as non-electrolytic, osmotic diuretic agent is widely used in clinic for the purpose of diagnosis and prevention of acute oliguric renal failure, cerebral edema as well as glaucoma and dialysis-disequilibrium syndrome. That mannitol may cause serious life-threatening situation if administered in a patient with renal problem has been well known. Recently, it has been published that mannitol may be nephrotoxic in patient...
Effects of long-term anticonvulsant therapy of thyroid function.
Sei Joong Ko, Duk Hi Kim, Chang Jun Coe
Clin Exp Pediatr. 1989;32(11):1533-1539.   Published online November 30, 1989
Serum concentrations of total triiodothyronine (T3) and thyroxine (T4) as well as serum thyroid- stimulating hormone (TSH) were measured in 108 patients with childhood epilepsy taking anticonvul- sants and in 54 normal healthy children as control group. Of these 108 patients, 23 were treated with carbamazepine alone, 17 were phenytoin alone and the rest 68 were treated with combination of two or more drugs...
A clinical studies on Wilson's disease.
Won Kyu Lee, Ki Sup Chung, Chang Jun Coe
Clin Exp Pediatr. 1989;32(11):1496-1502.   Published online November 30, 1989
The 12 cases of Wilson disease younger than the age of 18 years were observed at Severance hospital between Jan. 1980 and July 1988 and we obtained following results. 1) The mean age was 14 years old and male to female ratio was 2:1 2) The younger the patient, the clinical symptoms predominantly manifested hepatic dysfunction and the older patient manifested neurologic symptoms. 3) Kayser-Fleischer’s ring was the...
A Case of Narcolepsy.
Young Soo Lee, Chang Jun Coe
Clin Exp Pediatr. 1989;32(9):1309-1313.   Published online September 30, 1989
The narcoleptic syndrome consists of narcolepsy proper, cataplexy, sleep paralysis and hypnagogic hallucinations. The disease is not common in children. We experienced a case of narcolepsy in a 7-year old girl. Analeptic drugs are used for treatment. Diurnal attacks of sleep and concomitant muscular weakness were controlled with methylphenidate (ritalin hydrochloride) rather than caffeine, Historical literatures were also been reviewed, and several clinical aspects of...
A Case of Recurrent Bacterial Meningitis with CSF Rhinorrhea.
Dae Shik Kim, Jin Yong Lee, Chang Jun Coe, Jin Suk Suh
Clin Exp Pediatr. 1989;32(8):1161-1166.   Published online August 31, 1989
Recurrent bacterial meningitis is a rare disease which is associated with congenital or acquired anatomical defects of CNS and surround structures, or it may be due to parameningeal foci of infection, defects in immune response, and post-operative state of shunt procedure in hydrocephalus. We experienced the patient of recurrent bacterial meningitis with CSF rhinorrhea due to structural defect which was not defined exactly. We identified...
Clinical Study of Partial Agenesis of Callosum.
Seung Hwan Oh, Chang Jun Coe, Jung Ho Suh
Clin Exp Pediatr. 1989;32(4):511-517.   Published online April 30, 1989
26 cases of partial agenesis of the corpus callosum diagnosed at Pediatric Department of Yonsei Medical Center for 8 years from Jan. 1980 to Dec. 1987 and clinical information has been analized and we got following results. 1) The sex ratio of male to female was 1:1.9. 2) Among the 26 cases, 23 cases (88.5%) were diagnosed under 6 years old. 3) Clinical findings were...
A Case Posttraumatic Parkinsonism.
Young Wan Kim, Chang Jun Coe
Clin Exp Pediatr. 1989;32(3):438-443.   Published online March 31, 1989
We experienced a case of parkinsonism in a 6 year 4 month old boy who sustained basal skull fracture after outcar accident. The clinical features and response to therapy were described with brief literature review.
Comparative Study of the Abilities of Visual Motor Integration in Korea Children to That of Berry's Results.
Chang Jun Coe, Young Hyuk Lee
Clin Exp Pediatr. 1989;32(2):191-197.   Published online February 28, 1989
Visual.Motor Integration (VMI) test, designed by Beery, is one of the battery, which is commomly used in investigating the developmental status of child. As the test was designed for American children, the test may be not feasible for Korean children because of difference of cultural back. ground, race as well as econornic status. 1674 normal Korean children aged from 5 to 12 were tested...
A Case of Infantile Cortical Hyperostosis.
Jae Kyoun Rhim, Young Hyuk Lee, Chang Jun Coe, Duk Jin Yoon
Clin Exp Pediatr. 1988;31(11):1494-1498.   Published online November 30, 1988
Recently we have experienced a case of infantile cortical hyperostosis. The patients was 2 months old male who complained irritability, soft tissue swelling of both lower extremities. X-ray showed periosteal new bone formation on both tibiae. Bone scan revealed hot uptake at the lesion. We are reporting this infantile cortical hyperostosis with reviewing literatures.
Neurologic Outcome in Congenital Hypothyroidism.
Byeung Ju Jeoung, Duk Hi Kim, Chang Jun Coe, Hang Cho Kang
Clin Exp Pediatr. 1988;31(7):901-913.   Published online July 31, 1988
Congenital hypothyroidism is one of the most common endocrine disease in childhood and is a major cause of mental retardation. It is clear that the earlier treatment is started, the better intellec- tual potential and the likely absence of neurological sequellae. The present study was carried out to try to define the incidence and the nature of the neurologic disorders and to examine the...
A Case of Multiple Congenital Abnormalities Associated with Ring Chromosome 13.
Yung Hyuk Lee, Dong Won Choi, Chang Jun Coe, Kir Young Kim
Clin Exp Pediatr. 1988;31(4):506-510.   Published online April 30, 1988
A case of ring chromosome 13 has been experienced in 1 year and 9 month old female child recently. This female child manifested psychomotor retardation and multiple congenital anomalies. The diagnosis was made on the basis of typical morphologic features and chromosome study. As this is the first case in Korea, it is worthwhile to report with reviewing literature.
Clinical Evaluation of the Arachnoid Cysts in the Pediatric Age Group.
Ho Taek Kim, Young Hyuk Lee, Chang Jun Coe
Clin Exp Pediatr. 1988;31(4):467-473.   Published online April 30, 1988
Arachnoid cysts are benign cysts occuring in the cerebrospinal axis in relation to the arachnoid membrane. From Jan, 1974 unitl June, 1986. we evaluated the clinical features and outcome of the arachnoid cyst by the review of the medical records and followup study of 20 cases in pediatric age group, and the results are as follows: 1) The age distribution of the patients was from 2...
Visual Motor Integration Abilities of Children with Learning Disorders.
Chang Jun Coe, Young Hyuk Lee, Jung Keun Kim
Clin Exp Pediatr. 1988;31(3):339-347.   Published online March 31, 1988
Children with learning problems are known to a social, educational as well as neurological problems. Learning disorder is usually defined as following children with normal intelligence and without serious psychological problems experiencing serious degree of difficulty to acquire a proper skill to learn, reading, writing and calculation. These children are usually hyperactive, easily distractable, may manifests defect in visual motor integration and various soft neurologic signs. As...
2 Cases of Infantile Spasms(Cryptogenic Type) Treated with ACTH Therapy.
Shin Heh Kang, Chang Jun Coe
Clin Exp Pediatr. 1987;30(8):928-933.   Published online August 31, 1987
We have experienced 2 cases of infantile spasms treated with ACTH. They were diagnosed as cryptogenic type within relatively short duration after the onset. With the administration of ACTH, flexor spasms and hypsarrhythmia disappeared. They did not demonstrate any intellectual impair- ment on OPD follow up study. A brief review of literatures was made.
Neurological Assessment of Children with Learning Disable, Studying Disable, Studying Special Class at Primary School.
Chang Jun Coe
Clin Exp Pediatr. 1986;29(5):510-516.   Published online May 31, 1986
1) Neurological assessment has been done in children with learning disorders, who are rological problems. The high incidence of neurologic defect is thought that those children are not purely child with learning disorder but many of them are handicapped children as well as mentally retarded ones. Neurological problems they manifested are organic brain dysfunction, children with severe psychological roblem, attention...
Case Report
A Case of Silver Russel Syndrome.
Kee Hyuck Kim, Chang Jun Coe, Duk Jin Yun
Clin Exp Pediatr. 1986;29(3):318-321.   Published online March 31, 1986
Recently, we have experienced a case of Silver-Russel syndrome, representing short sature, asymmetric skeletal development causing hemihypertrophy, macrocephaly and clinodactily. We are reporting this case with brief review of literatures.
Original Article
Clinical Study of Therapeutic Effect in Status Epilepticus.
Young Hyuk Lee, Chang Jun Coe
Clin Exp Pediatr. 1986;29(1):72-78.   Published online January 31, 1986
A clinical studies were conducted to determine the effectiveness of anticonvulsant treatment in 90 cases of status epilepticus in children who had been admitted to Pediatric Department of Yonsei University Medical Center from January 1979 to July 1984. The results were obtained as follows: 1) The incidence was 9.9% of epileptics who visit to our clinic at the same period of time. 2) In...
Case Report
A case of Myoclonic Encephalopathy associated with Neuroblastoma.
Jae Seung Yang, Chang Jun Coe, Han Gu Mun, Chan Il Park
Clin Exp Pediatr. 1985;28(9):926-930.   Published online September 30, 1985
We experienced a case of myoclonic encephalopathy, associated with occult neuroblastoma. This 14 months old male child manifested opsoclonus, myoclonic seizure as well as delayed development. This patient also, had neuroblastoma, which has been removed. After the surgical removal of the tumor, the opsoclons was not disappeared.
A Case of Phenylketonuria.
Ki Suk Bahn, Jin Yong Lee, Chang Jun Coe
Clin Exp Pediatr. 1985;28(1):99-102.   Published online January 31, 1985
Lately, we experienced a case of classic PKU and we report this with reviewing the references.
Pseudohypoparathyroidism and Peudopseudohypoparathyroidism in a Family.
Young Cherl Lee, Duk Hee Kim, Chang Jun Coe
Clin Exp Pediatr. 1984;27(11):1128-1134.   Published online November 30, 1984
We are reporting the cases of 2 patients in a family, younger sister and elder brother, who exhibit skeletal and physiognomonic characteristic pictures of PHP and PPHP. In this report, we illustriated pertinent clinical and pathologic features of this diseases in children and revi- ewed the literature concerning this diseases.
Original Article
A Clinical Investigation on 10 Patients of Tuberous Sclerosis.
Hee Jung Chung, Myung Jin Kim, Chang Jun Coe
Clin Exp Pediatr. 1983;26(4):373-379.   Published online April 30, 1983
We reviewed 10 cases of Tuberous sclerosis clinically during the last 2 years from March 1980 to June 1982 and the following conclusion was obtained: 1) The younger children may have cafe au lait spots and depimentation with seizure and psychomotor retardation as the diagnostic clues, while the older one may have Adenoma sebaceum. 2) Computerized tomography of brain is essential for diagnosis as it discloses...
Case Report
Hereditary Spastic Paraplegia.
Nan Ae Kim, Moon Ki Cho, Chang Jun Coe, Duck Jin Yun, Jung Ho Suh
Clin Exp Pediatr. 1982;25(5):498-502.   Published online May 31, 1982
Hereditary spastic paraplegia is a familial disorder which is inherited by autosomal dominant, autosomal recessive or sex linked pattern. We experienced a family who has hereditary spastic paraplegia with mental retardation and extrapyramidal symptom that is thought inherited by autosomal dominant inheritance pattern. A review of literatures was made briefly.
Original Article
Clinical Diagnosis of Mental Handicap Child and Their Assessment.
Chang Jun Coe
Clin Exp Pediatr. 1981;24(10):911-919.   Published online October 15, 1981
140 cases of mentally handicapped children were investigated for clinical diagnosis and assessed for their abilities by Griffith test. The youngest child was 1 month old and the oldest was 15 years old. The clinical diagnosis was able to make in 75%: 40% was cerebral palsy and the rest 35% showed various diagnosis. In 25%, etiological diagnosis was not able...
Intracranial Cysticercosis: A Report of 6 Cases.
Sang Hak Park, Chang Jun Coe, Duk Jin Yun, Sang Sup Chung, Kyu Chang Lee, Jung Ho Suh
Clin Exp Pediatr. 1981;24(8):766-771.   Published online August 15, 1981
Cysticercosis infestation is a cosmopolitan disease. Recently we experienced six cases of intracranial cysticercosis in childhood, three of them were male and their age distributed from 2 to 15 years. Their main clinical manifestations were symptoms of increased intracranial pressure signs and other neurological sings as well, In diagnostic procedures, brain C-T scan was performed in all cases and Conray...
Clinical Obseervation and Changing Patterns of Resistance to Antibiotics in Childhood Shigellosis.
Young Mo Sohn, Kwand Ho Kim, Chang Jun Coe, Pyung Kil Kim, Duk Jin Yun
Clin Exp Pediatr. 1981;24(3):229-234.   Published online March 15, 1981
This paper presents 97 patients of childhood shigellosis which was proved by stool cultures. 44.3% of all patients was accompanied with convulsion. All convulsions were developed under the 6 years of age and associated with high fever. The prognosis was poor in convulsive 容roup. Spinal tapping was performed in 30 patients, in which 3 cases of meningitic type were found....
Clinical Study on Spina Bifida and Cranium Bifidum.
Hee Seon Auh, Kwan Sub Chung, Chang Jun Coe, Duk Jin Yun
Clin Exp Pediatr. 1981;24(2):128-135.   Published online February 15, 1981
Spina bifida or cranium bifidum result from a failure in fusion of skull(cranium bifidum) or the vertebral column(spina bifida). These entities are the most common anomalies of the nervous system which are associated with major abnormalities of cellular migration, and secondary mechanical deformities of the nervous system. During the last 12 years from Jan. 1967 to Dec. 1978, 83 cases...
Serratia marcescens sepsicemia; Nosocomial outbreak.
Ran kung Nam, Jun Hee Sul, Chang Jun Coe, Pyung Kil Kim, Duk Jin Yun, Young Nam Lee
Clin Exp Pediatr. 1980;23(11):901-910.   Published online November 15, 1980
An outbreak of nosocomial infections caused by Serratia marcescens is described. There were 40 bacterial isolates from 21 patients during a 3 month period at pediatric ward and sick baby room. Bacterial cultures from blood revealed positive in 19 patients out of 21, but one from urine and the other from bronchial secretions. 16 cases among 19 Serratia septicemia were...