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Purpose : We'd like to evaluate the relationship between the degree of cardiac damage and that
of cardiac function according to the total injected dose of doxorubicin.
Methods : 12 rabbits(body weight : 2.0-3.2 kg) were used and 30 mg/m2/week of doxorubicin hydrochloride
was injected intravenously. The cardiac function was checked under anesthesia, after which the
thorax was opened and cardiac samples were evaluated... |
