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Original Article

Immunohistochemical Expression of c-fos Protein and Histologic Findings after Instillation of Kainic Acid in Hippocampus of Neonatal Rat Brain

Soo Ahn Chae, Yong Soo Kim, Byoung Hoon Yoo, Won Bok Lee

Clin Exp Pediatr. 1999;42(4):553-560. Published online April 15, 1999

Purpose : c-fos is rapidly and transiently induced in the intact CNS by a wide variety of exogenous stimuli that include seizures, glutamate receptor activation, sensory stimulation and stress. In adult animals, systemic KA administration produces limbic seizures that results in c-fos protein expression, irreversible morphological changes and localized neuronal death. So we studied the pattern of c-fos protein expression...

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