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Original Article
Different characteristic between Escherichea coli and non-Escherichea coli urinary tract infection
Hee Jin Jung, Ji A Aum, Soo Jin Jung, Jae Won Huh
Clin Exp Pediatr. 2007;50(5):457-461.   Published online May 15, 2007
Purpose : Urinary tract infection (UTI) is a common bacterial infectious disease in childhood. Especially UTI in infant and young children is associated with urinary tract anomalies such as hydronephrosis, vesicoureteral reflux. The aim of this study was to compare the clinical and laboratory characteristics, and uroradiologic findings of UTI caused by pathogens other than E. coli with UTI caused...
Antithrombin-III as an early prognostic factor in children with acute lung injury
Young Seung Lee, Seonguk Kim, Eun Kyeong Kang, June Dong Park
Clin Exp Pediatr. 2007;50(5):443-448.   Published online May 15, 2007
Purpose : To evaluate the potential prognostic value of the antithrombin-III (AT-III) level in the children with acute lung injury (ALI), we analyzed several early predictive factors of death including AT-III level at the onset of ALI and compared the relative risk of them for mortality. Methods : Over a 18-month period, a total of 198 children were admitted to our...
Review Article
Lung function tests in preschool children
Yong-Mean Park
Clin Exp Pediatr. 2007;50(5):422-429.   Published online May 15, 2007
Measurement of lung function is an integral component of respiratory physiology and of clinical assessment of lung diseases in school age children and adults. Pulmonary function test of infants and children under the age of 2 years have now been standardised and are being used both in research and as an adjunct to clinical management. By contrast, until recegntly, children...
Original Article
A comparison of provoked seizures and febrile seizures associated with minor infections
Eun-Ju Lee, Won Seop Kim
Clin Exp Pediatr. 2007;50(4):376-380.   Published online April 15, 2007
Purpose : Febrile seizures occur in childhood associated with a febrile illness not caused by infections of the central nervous system. Provoked seizures are identified with seizures in association with infections that do not usually affect the brain such as gastroenteritis, except criteria for other febrile seizures in this study. We studied seizures provoked by minor extracranial infections, to contrast...
The immunogenicity and safety of three-component DTaP vaccine in Korean infants
Jin Han Kang, Jong Hyun Kim, Jung Hyun Lee, Soo Young Lee, Young Jin Hong, Chang Hwi Kim
Clin Exp Pediatr. 2007;50(4):355-362.   Published online April 15, 2007
Purpose : We conducted the study to evaluate the immunogenicity and safety of three component DTaP vaccine (Infanrix ) in a group of Korean healthy infants on a three-dose primary vaccination. And we compared the immunogenicity of this DTaP vaccine with two component DTaP vaccine which has been widely used in Korea. Methods : We enrolled one hundred fifty one healthy...
The outcome of perinatal prophylaxis for HBeAg positive mothers according to the maternal HBV-DNA levels at the delivery time
On Jeong, Jong-Hyun Kim
Clin Exp Pediatr. 2007;50(4):347-354.   Published online April 15, 2007
Purpose : Perinatal hepatitis B viral infection is decreasing; however, 10% of babies to HBeAg positive mothers still become chronic carriers despite perinatal prophylaxis. Although, the cause of prophylaxis failure is still unclear, an importance of maternal HBV-DNA level at the delivery time has been suggested. This study was established to certify if it would be a useful predictable factor...
A review of the contents about childhood health care in middle & high school textbooks
Jung Hun Kim, Sung Won Park, Son Moon Shin, In Kyung Sung, Mi Jung Park, Yoo Mi Chung, Jeong Hun Ha
Clin Exp Pediatr. 2007;50(4):340-347.   Published online April 15, 2007
Purpose : The purpose of this study is to investigate the material in middle school and high school textbooks covering child care and children's health for medically inaccurate content and to make sure that the correct information is given to students. Methods : We have examined 47 kinds of textbooks on the subjects 'Home economics' and 'Technology and home economics' published...
Erratum
A study of elementary school pupils using traditional herbal medicines
Young Joon Ahn
Accepted January 1, 1970  
Purpose : Traditional herbal medicines may be overused in Korea. Expenditures and inaccuracies of hospital prescription are increasing gradually. So we investigated the frequency and nature of herbal medicine use among elementary school pupils. Methods : We interviewed students of three elementary schools located in Gwangju with survey papers. We analyzed 905 returned surveys. Results : They consisted of 421 males...
Case Report
Joubert syndrome with peripheral dysostosis - A case report of long term follow-up -
Jung Tae Kim, Sun Jun Kim, Chan-Uhng Joo, Soo Chul Cho, Dae-Youl Lee
Clin Exp Pediatr. 2007;50(3):315-318.   Published online March 15, 2007
This report describes the long-term follow-up of a 10-year-old female patient with Joubert syndrome with short stature and brachydactyly. She presented with hyperpnea alternated with hypopnea, uncontrolled jerking eye movements, and hypotonia during early infancy. She was diagnosed with Joubert syndrome based on clinical symptoms and typical MRI findings at 5 months of age. Abnormal ventilation and eye movements disappeared...
A case of restrictive dermopathy
Seung Ik Lee, Chang Hee Hong, Yun Ha Cheong, Mi Seon Kang, Jong Beom Sin
Clin Exp Pediatr. 2007;50(3):306-310.   Published online March 15, 2007
Restrictive dermopathy is a rare autosomal recessive disorder in which rigidity or tautness of the skin from the second trimester causes a fetal akinesia deformation sequence (FADS) and early death. Characteristic features include taut skin with prominent subcutaneous vessels, widely open fontanelles and cranial sutures, distinctive facies, flexion contractures, pulmonary hypoplasia, sparse eyelashes and and eyebrows, thin dysplastic clavicles. The...
Two cases of postoperative chylothorax treated with parenteral octreotide and conservative therapy
Eun Jin Choi, Sub Lee
Clin Exp Pediatr. 2007;50(3):298-301.   Published online March 15, 2007
Chylothorax is a rare complication following cardiac surgery for congenital heart diseases. Although conservative management is successful in the majority of cases, surgical intervention is required in a refractory one. Recently, subcutaneous or intravenous infusion of octreotide has been used as a safe treatment that helps avoiding surgical intervention. Herein, we report two cases of postoperative chylothorax treated with parenteral...
Original Article
Growth promoting effect of short-term gonadotropin releasing hormone agonist with or without growth hormone in girls with early puberty
Eun-Ju Lee, Heon-Seok Han
Clin Exp Pediatr. 2007;50(2):198-204.   Published online February 15, 2007
Purpose : The hope that arresting pubertal developement might increase final adult height has led to an attempt to use GnRH agonist (GnRHa) in children with early puberty and poor growth prognosis. We investigated the growth-promoting effect of GnRH agonists with or without growth hormone (GH) in girls with early puberty and decreased predicted adult height (PAH). Methods : Thirty five...
Comparison of growth and neuropsychological function after treatment for hematologic and oncologic diseases in monozygotic twins
Gi Hwan Kim, Hoon Kook, Hee Jo Baek, Dong Kyun Han, Eun Song Song, Young Kook Jo, Ic Sun Choi, Young Ok Kim, Chan Jong Kim, Young Jong Woo, Soo Jin Yang
Clin Exp Pediatr. 2007;50(2):182-189.   Published online February 15, 2007
Purpose : The primary purpose of this study was to evaluate the growth and neuropsychologic function following treatments for pediatric hematologic and oncologic diseases. Healthy monozygotic twins served as ideal controls for comparison to exclude possible confounding factors. Methods : Seven children treated with various hematologic and oncologic diseases were included in the study: acute lymphoblastic leukemia (ALL; n=2), Diamond-Blackfan anemia...
A clinical study of child bacterial meningitis in Daejeon and Chungcheong area : 2001-2005
Yong Joo Lee, Soo Jin Lee, Ho Jin Park, Young Hyuk Lee, So Young Kang, Young Chang Kim, In Kyu Lee, Kyung Yeon Lee, Keon Su Lee, Won Seop Kim
Clin Exp Pediatr. 2007;50(2):157-162.   Published online February 15, 2007
Purpose : The purpose of this study was to analyze the epidemiology, causative organism, clinical manifestation and prognosis of bacterial meningitis for children after the introduction of Haemophilus influenzae type b (Hib) vaccine in Daejeon and Chungcheong area. Methods : We analyzed retrospectively 53 medical records who had been diagnosed with bacterial meningitis at 10 general or university hospitals...
Etiological agents isolated from blood in children with hemato-oncologic diseases (2002-2005)
So-Hee Kim, Young-Ah Lee, Byung-Wook Eun, Nam-Hee Kim, Jin-A Lee, Hyoung Jin Kang, Eun-Hwa Choi, Hee Young Shin, Hoan-Jong Lee, Hyo Seop Ahn
Clin Exp Pediatr. 2007;50(1):56-64.   Published online January 15, 2007
Purpose : This study was performed to identify the etiologic agents and antimicrobial susceptibility patterns of organisms responsible for bloodstream infections in pediatric cancer patients for guidance in empiric antimicrobial therapy. Methods : One hundred and ninety-seven episodes of bloodstream infections that developed in 128 pediatric cancer patients were analyzed, which were identified at the Seoul National University Children's Hospital during...
Long term prognosis of patients who had a Fontan operation
Hyun-Jung Kim, Eun-Jung Bae, Jung-Il Noh, Jung-Yun Choi, Yong-Su Yun, Wong-Hwan Kim, Jung-Yeul Lee, Yong-Jin Kim
Clin Exp Pediatr. 2007;50(1):40-46.   Published online January 15, 2007
Purpose : This study assessed the long term survival rate and long term complications of patients who had a modified Fontan operation for functionally univentricular cardiac anomaly. Methods : Between June 1986 and December 2000, 302 patients with a functional single ventricle underwent surgical interventions and were followed up until February 2006. The mean follow-up period was 8.3?.3 years (range 3.5-18...
Review Article
Regionalization of neonatal care and neonatal transport system
Jong Beom Sin
Clin Exp Pediatr. 2007;50(1):1-6.   Published online January 15, 2007
In the United States, The concept of designation for hospital facilities that care for newborn infants according to the level of complexity of care provided was first proposed in 1976. The extent of perinatal health care regionalization varies widely from one area to the other. facilities that provide hospital care for newborn are classified into three categories on the basis...
Case Report
A case of congenital ductus arteriosus aneurysm
Sheng Wen Wang, Ji Eun Kim, Young Seok Lee, Young Ah Lee
Clin Exp Pediatr. 2006;49(12):1363-1366.   Published online December 15, 2006
Aneurysmal dilatation of the ductus arteriosis has been considered a rare but potentially fatal abnormality. The mechanism of ductal aneurysmal formation remains uncertain. Plain chest radiography has proven helpful in the diagnosis of ductus arteriosus aneurysm (DAA), before the application of transthoracic echocardiography. The transthoracic echocardiography is an important tool for the diagnosis and follow-up of DAA. We present a...
Original Article
The effects of ibuprofen and indomethacin therapy for patent ductus arteriosus in preterm infants
Wooksun Choi, Jung-Yeon Shin, Byung Min Choi, Baik-Lin Eun, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee
Clin Exp Pediatr. 2006;49(12):1315-1323.   Published online December 15, 2006
Purpose : This study was conducted to compare the efficacy and safety of ibuprofen and indomethacin in the treatment of patent ductus arteriosus (PDA) in preterm infants and to determine whether ibuprofen can be an alternative drug. Methods : A total of 32 preterm infants with symptomatic PDA were enrolled in the study. Twelve infants received intravenous ibuprofen 10 mg/kg, followed...
Clinical characteristics and risk factors for staphylococcal infections in neonatal intensive care unit
Min Kook Chung, Jeong Ho Choi, Jin Keun Chang, Sung Hoon Chung, Chong Woo Bae, Sung Ho Cha
Clin Exp Pediatr. 2006;49(12):1287-1295.   Published online December 15, 2006
Purpose : The importance of staphylococcal infections in NICU has been emphasized in terms of increased resistant strains and increased incidence of morbidity and mortality. In this study, we inrestignted the clinical characteristics and risk factors for staphylococcal infections, and looked into sensitivity trends of antibiotics in the era of a high rate of methicillin-resistant staphylococcus aureus (MRSA) in our...
Short-term follow up of thyroid function after pediatric hematopoietic stem cell transplantation
Seon-Ju Lee, Jae-Wook Lee, Dae-Hyoung Lee, Young-Joo Kwon, Young-Shil Park, Hui Sung Hwang, Sun Young Kim, Ji Kyoung Park, Pil-Sang Jang, Min-Ho Jung, Nak-Gyun Chung, Dae-Chul Jeong, Bin Cho, Hack-Ki Kim, Byung-Churl Lee
Clin Exp Pediatr. 2006;49(11):1211-1215.   Published online November 15, 2006
Purpose : In this study, we analyzed the short term changes of thyroid function, incidence and risk factors of thyroid dysfunction soon after allogeneic hematopoietic stem cell transplantation (HSCT) in children. Methods : We enrolled 80 pediatric patients following allogeneic HSCT, at the Catholic HSCT center between January, 2004 and February, 2006. Serum TSH (thyroid stimulating hormone), total serum thyroxine and...
Modified Tei index in patients with Kawasaki disease by tissue doppler imaging
Hee Jung Kim, Jung Hwa Cha, Young Mi Hong
Clin Exp Pediatr. 2006;49(11):1202-1210.   Published online November 15, 2006
Purpose : A quantitative and easily measured Doppler index of combined systolic and diastolic ventricular myocardial performance (Tei index) was recently proposed as a potentially useful predictor of global myocardial performance. However, presence of heart rate fluctuation makes it unreliable. Therefore, the modified Tei index was introduced by using tissue Doppler imaging (TDI) which enables measuring contraction and relaxation velocities...
Cause of enteroviral infection in children in chungnam area summer, 2005
Se Yun Jeon, Suk Joo Choi, Yong Bae Kim, Hae Seon Nam, Kwi Sung Park, Kyung Ah Baek, Joon Soo Park
Clin Exp Pediatr. 2006;49(11):1186-1193.   Published online November 15, 2006
Purpose : Enterovirus infection is a type of viral infection that occurs relatively frequently in children during summer. It has clinical symptoms of non-specific fever, aseptic encephalomeningitis, gastrointestinal diseases, skin rash and, hand-foot-mouth disease. However, it can also occcaisionally, result in fatal symptoms like myocarditis, epicardial inflammation, transverse myelitis, quadriplegia and etc. There have been epidemic enterovirus studies, but not...
Diagnostic value of various screening tests in neonatal sepsis
Hyun Gon Je, Young Mi Jeoung, Soo Jin Jeong
Clin Exp Pediatr. 2006;49(11):1167-1173.   Published online November 15, 2006
Purpose : To evaluate various sepsis screening tests, individually and in combination, to formulate a guideline for the diagnosis of neonatal sepsis. Methods : The study was a retrospective cohort study. It took place at the neonatal intensive care unit of the Paediatric Department, Il Sin Christian Hospital, Busan, Korea, over a period of 68 months from 1st, April, 2001 to...
Review Article
Treatment and management of patients with inherited metabolic diseases
Jin-Sung Lee
Clin Exp Pediatr. 2006;49(11):1152-1157.   Published online November 15, 2006
Inherited metabolic disease is rare disorders that show symptoms mainly in pediatric age and early treatment is important for preventing complications of the disease. Recent development in molecular and biochemical techniques help clinicians with proper diagnosis of patients, however, many of the disease still remain lack of effective therapeutic strategies. Better understanding on biochemical and molecular basis of pathogenesis of...
Case Report
A case of pyomyositis due to Mycobacterium tuberculosis
Yun-Jin Bae, Jin-Sung Choi, Young Ah Lee, Sung-Soo Kim, Seo-Hee Rha, Jin-A Jung
Clin Exp Pediatr. 2006;49(10):1116-1119.   Published online October 15, 2006
Pyomyositis is a primary bacterial infection of the skeletal muscles. Although infection can affect any skeletal muscle, the large muscle groups such as the quadriceps or gluteal muscles are most often the focus of this disease, and most commonly the inflammation is focal, involving a single muscle. The mechanism of pyomyositis is poorly understood. The local mechanical trauma at the...
Original Article
Serum homocysteine and tumor necrosis factor-alpha levels after intravenous gammaglobulin treatment in patients with Kawasaki disease
Jung Hwa Cha, Young Mi Hong
Clin Exp Pediatr. 2006;49(10):1093-1099.   Published online October 15, 2006
Purpose : Homocysteine is a strong and independent risk factor for cardiovascular disease. The deleterious effects of homocysteine included endothelial dysfunction, arterial intimal-medial thickening, wall stiffness and procoagulant activity. However, the precise mechanism responsible for homocysteine release in children with coronary artery disease is still unknown. The purpose of this study was to investigate serum homocysteine and tumor necrosis factor(TNF)-α...
Clinical significance of cerebrospinal fluid pleocytosis in pediatric refractory status epilepticus
Jung Mi Kim, Young Mi Kim, Soon Hak Kwon
Clin Exp Pediatr. 2006;49(10):1086-1092.   Published online October 15, 2006
Purpose : Refractory status epilepticus(RSE) is a serious neurological emergency in children. The mortality is high and the neurological outcome is not good. This study aimed to evaluate the clinical significance of cerebrospinal fluid(CSF) pleocytosis in refractory status epilepticus in children. Methods : From January 1999 to January 2006, 25 out of 37 children with refractory status epilepticus had...
Changes of neurodevelopmental outcomes and risk factors of very low birth weight infants below 1,500 g, in the last 10 years
Se Kyu Lee, Ji Hyun Lee, Sang Geel Lee
Clin Exp Pediatr. 2006;49(10):1050-1055.   Published online October 15, 2006
Purpose : As a result of advances in neonatal intensive care and perinatal care, neurodevelopmental outcomes of very low birth weight infant(VLBWIS) is expected to lead to improvement. The aim of this study was to report neurodevelopmental outcomes and risk factors of neurologic impairment of very low birth weight infants during the past 10 years. Method : We performed a retrospective...
Case Report
A case of true thymic hyperplasia in the mediastinum with ectopic thymus in the neck
Hyun-Jung Kim, Sun-Hwa Jang, Ji-Sook Park, Eun-Sil Park, Ji-Hyun Seo, Jae-Young Lim, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn
Clin Exp Pediatr. 2006;49(9):996-999.   Published online September 15, 2006
True thymic hyperplasia and ectopic thymus are very rare in children. In embryologic aspect, thymus is distributed around cervical area and ends up in mediastinum. This case is simultaneous thymic hyperplasia of neck and mediastinum. Ectopic thymus in the neck and thymic hyperplasia in the mediastinum in children were reported 2 and 7 cases respectively in Korea. In Clinical aspects,...