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Original Article
Effect of Delayed Intensification on Survival of Childhood Acute Lymphoblastic Leukemia
Jie Yeon Lee, Sue Youn, Byoung Chul Kwon, Chuhl Joo Lyu, Hwang Min Kim
Clin Exp Pediatr. 2003;46(12):1260-1265.   Published online December 15, 2003
Purpose : In 1970, the Berlin-Frankfurt-Munster(BFM) group introduced an intensification therapy after remission induction to reduce relapse of acute lymphoblastic leukemia(ALL) in childhood. Delayed intensification(DI) phase has been included for treatment of ALL in our hospital since the mid-1990s. The purpose of this study is to evaluate the outcome with vs. without DI phase and the outcome with two vs....
A Five-year Epidemiologic Study of Childhood Leukemia in Busan City, 1996 to 2000
Jae Hoon Moon, Soon Yong Lee, Jong Beom Sinn, Jae Sun Park, Young Ho Lee, Young Tak Lim, Su Eun Park
Clin Exp Pediatr. 2003;46(10):972-976.   Published online October 15, 2003
Purpose : For the control of childhood leukemia, of which the mortality is still high, the basic data for the incidence has a great importance. The authors analyzed the data from 133 new patients with childhood leukemia between 1996-2000 in Busan, Korea. Methods : The data were obtained from 133 new cases(87 males and 46 females from 0 to 15 years...
Efficacy of Antiepileptic Drug on the Benign Childhood Epilepsy with Centro-Temporal Spikes
Mee Hye Oh, Soo Young Kim, Won Hee Seo, Dae Hun Pee, Byung Min Choi, Baik-Lin Eun
Clin Exp Pediatr. 2003;46(9):893-897.   Published online September 15, 2003
Purpose : Benign childhood epilepsy with centrotemporal spikes(BECT) is characterized by an excellent prognosis. Therefore, the necessity for the use of antiepileptic drugs is controversial. The object of this study is to know about the long-term follow-up of BECT, comparing daily treatment with antiepileptic drug(AED) versus no medication. Methods : We retrospectively studied 56 cases of BECTs, examined at Pediatric Neurology...
Follow-up Study of Children with Anthracycline Cardiotoxicity
Hyok Joo Kwon, Young Hwan Song, Soo Jung Kang, Hyoung Jin Kang, Hyoung Soo Choi, Eun Jung Bae, Hee Young Shin, Chung Il Noh, Yong Soo Yun, Hyo Seop Ahn
Clin Exp Pediatr. 2003;46(3):242-249.   Published online March 15, 2003
Purpose : We studied the relationship between anthracycline cumulative dose and anthracycline cardiotoxicity in childhood cancer and followed up 40 children with anthracycline cardiotoxicity. Methods : A retrospective study was performed in 154 children who received anthracycline chemotherapy between January 1995 to December 2000. Cardiotoxicity was defined when the left ventricular fractional shortening(FS) was below 26%; it was divided into two...
Clinical Study of Childhood Accidents from a Hospital Over Ten Years with Regard to Foreign Body Aspiration
Cheol-Min Kim, Jun-Young Song, Ja Hyung Kim, Ki Soo Kim, Soo-Jong Hong
Clin Exp Pediatr. 2002;45(9):1134-1140.   Published online September 15, 2002
Purpose : Childhood accidents have been increasing recently. Accidents rank as the leading cause of childhood mortality and morbidity. We performed this study to evaluate the causes of childhood accidents. Methods : The authors analysed retrospectively the medical records of 6,410 cases of childhood accidental injuries who visited the emergency room of Asan Medical Center from January 1990 to December...
Infectious Manifestations in Childhood Leukemia
Yoon Jung Cho, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 2001;44(9):1019-1030.   Published online September 15, 2001
Purpose : Infection is one of the major causes of morbidity and mortality in children during chemotherapy for leukemia and the development of fever in neutropenic cancer patients frequently indicates infection. The purpose of the present study is to evaluate infectious manifestations during the course of leukemia. Methods : Seventy eight leukemic children who had one or more occasions of infection during hospitalization from January...
Evaluation of the Severity in Patients with Bronchial Asthma Using FEF25-75%
Sun Yoon Jung, Eun Sil Lee, Young Hwan Lee, Han Ku Moon
Clin Exp Pediatr. 2001;44(8):916-921.   Published online August 15, 2001
Purpose : Spirometry, because of its simplicity and reproducibility, has been used to evaluate pulmonary function in childhood asthma. We investigated whether FEF25-75% is the most sensitive parameter among other spirometric parameters in the diagnosis of pulmonary function and airway obstruction. Methods : This study included 32 children with asthma. We recorded values of spirometry(FVC, FEV1, PEFR, and FEF25-75%) before and...
A Study of Acute Poisoning in Korean Children
Chan Sook Park, Song Hyeun Eun, Mi Hwa Yang, Jin A Son, Jung Yun Hwang, Jae Wook Ko, Don Hee Ahn
Clin Exp Pediatr. 2001;44(6):614-619.   Published online June 15, 2001
Purpose : The National Medical Center has been conducting a study as a Poison Control Center since 1998. The data was analyzed to illustrate the general aspects of acute poisoning in Korean children. Methods : The primary sources of data were collected from the Medical Insurance Records of 1997 and death records of the same period obtained from the Korea National Statistical Office. A total...
High-Resolution Computed Tomography(HRCT) Findings of the Lung in Asthmatic Children and Their Correlation with Clinical Characteristics
Do Kyun Kim, Yang Park, Young Yull Koh, Jung Eun Chun, Woo Sun Kim
Clin Exp Pediatr. 2000;43(12):1583-1590.   Published online December 15, 2000
Purpose : The purposes of this study were to determine the abnormal high-resolution computed tomography(HRCT) findings of the lung in uncomplicated asthmatic children, to compare the clinical characteristics between normal and abnormal HRCT finding groups and to correlate abnormal HRCT findings with clinical characteristics, especially FEV1 and PC20. Methods : Forty asthmatic children were studied. Inspiratory and expiratory HRCT scans were...
Clinical Features of Hemolytic Uremic Syndrome in Children
Ju Eun Lee, Su Yung Kim
Clin Exp Pediatr. 2000;43(11):1473-1479.   Published online November 15, 2000
Purpose : Hemolytic uremic syndrome(HUS) is the most common cause of renal failure in childhood in western countries, but it has been a relatively rare disease in Korea. To analyze the clinical and epidemiologic characteristics of HUS in Korea, we reporte our experience. Methods : We reviewed retrospectively the medical records of 9 patients who were diagnosed the hemolytic uremic syndrome...
Case Report
A Recurred Case of Subacute Necrotizing Lymphadenitis(Kikuchi`s Disease) During Childhood
Jin Sun Park, Chang Hee Oh, Je Woo Kim, Phil Soo Oh, Young Ah Lee, He Sun Yun, Jung Weon Shim
Clin Exp Pediatr. 2000;43(9):1285-1289.   Published online September 15, 2000
Subacute necrotizing lymphadenitis, or Kikuchi`s disease, primarily affects the cervical lymph nodes of young adults and has a self-limited clinical course. Differential diagnoses are malignant lymphoma and systemic lupus erythematosus. Recurrence rate is low as 3.3%, and there have been a few reports describing the recurrence of the disease. The symptoms in almost all recurrent cases were similar to those...
A Case of Relapsed Acute Promyleocytic Leukemia Induced Remission with Arsenic Trioxide(As2O3)
Jin Hye Park, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 2000;43(8):1132-1136.   Published online August 15, 2000
Acute promyelocytic leukemia(APL) is a unique entity in the spectrum of acute myelogenous leukemia. It has several characteristic features, including distinctive morphology, chromosomal translocation, t(15:17), disseminated intravascular coagulation and effect on retinoic acid. Retinoic acid which is a derivative of vitamin A induces differentation of APL cells in vitro and in vivo, but its cessation induces relapse of APL. Arsenic...
Original Article
A Study of Clinical Features of Acute Tumor Lysis Syndrome in Children
Ick-Jin Song, Young-Tak Lim
Clin Exp Pediatr. 2000;43(7):952-958.   Published online July 15, 2000
Purpose : Tumor lysis syndrome is characterized by hyperuricemia, hyperphosphatemia, hyperkalemia and hypocalcemia due to destruction of tumor cells. The purpose of this study is to estimate in children the incidence, onset time, differences in outcomes between hemodialysis and conservative therapy, and predictive factor of tumor lysis syndrome before treatment with chemotherapy. Methods : Subjects were 108 children who had received...
Characteristics of Childhood Asthma According to the Onset of Wheezing
Yoon Jeong Kim, Bong Seong Kim, Soo-Jong Hong
Clin Exp Pediatr. 2000;43(5):686-693.   Published online May 15, 2000
Purpose : To understand the characteristics of early childhood asthma, we evaluated and compared the characteristics between early persistent wheezers and late wheezers. Methods : From January, 1998 to December, 1998, 106 children aged six to seven years were divided into three groups according to the onset of wheezing : Early persistent wheezers(n=36) who had wheezing both before three years of...
Case Report
Three Cases of Subacute Necrotizing Lymphadenitis in Childhood
Min Hyang Park, Jin A Son, Jae Wook Go, Jae Yoon Kim, Don Hee Ahn
Clin Exp Pediatr. 2000;43(3):423-427.   Published online March 15, 2000
Subacute necrotizing lymphadenitis was first reported by Kikuchi and Fujimoto in 1972. Young females no more than 30 years of age are mainly affected. It usually manifests as fever and cervical lymphadenopathy. We experienced three cases of subacute necrotizing lymphadenitis in an 11-year-old boy, a 12- year-old boy and an 11-year-old girl. Symptoms presented were URI signs, diarrhea, headache and...
Original Article
Anticancer Effect of Arsenic Trioxide in Acute Promyelocytic Leukemia
Ki Young Song, Jin Hye Park, Yoon Jung Cho, Won Ki Baek, Ki Young Kwon, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 2000;43(3):327-334.   Published online March 15, 2000
Purpose : Acute promyelocytic leukemia(APL or AML, M3) represents an unique model for cancer research in terms of biological and clinical features. Since 1988, it has been widely confirmed that all-trans retinoic acid(ATRA) can induce complete clinical remission in over 85% of APL patients by a differentiation process, with PML-RARα protein possibly being the direct target of ATRA. However, ATRA...
A Clinico-pathologic Study of Childhood Lupus Nephritis
Youn-Sook Rho, Sung-Hoo Cha, Byoung-Soo Cho
Clin Exp Pediatr. 2000;43(2):236-240.   Published online February 15, 2000
Purpose : Systemic lupus erythematosus(SLE) is a disease of immunologic origin, affecting multiple organs including joints, skin, kidneys, nervous system, heart and blood, with rare involvement of gut and liver. The incidence of renal disease in children with SLE was approximately 70 percent and tended to be more severe than in adults. Accordingly we have retrospectively studied on the prognostic...
Age-Related Criteria for Signal-Averaged Electrocardiographic Late Potentials in Children
Heon-Seok Han, Ki-Moon Cha
Clin Exp Pediatr. 1999;42(5):679-685.   Published online May 15, 1999
Purpose : Ventricular late potentials have been shown to predict malignant ventricular arrhythmia and sudden cardiac death in patients with myocardial infarction and cardiomyopathy. Low amplitude and high frequency potentials at the end of the QRS complex can be detected on the body surface using signal-averaged electrocardiogram(SAECG). This study determines the age-related criteria of SAECG parameters and age-related differences. Methods :...
Case Report
Two Cases of Thymic Carcinoma in Childhood
Young Ah Lee, Jin Young Park, Hye Lim Jung, Moon Soo Par, Hyoung Soo Choi, Eun Sun Yoo, Hyo Seop Ah
Clin Exp Pediatr. 1999;42(3):424-429.   Published online March 15, 1999
Thymic carcinoma is a malignant neoplasm arising from the thymic epithelium, and is known to be extremely uncommon in the pediatric population. The tumor is clinically highly aggressive with frequent local intrathoracic spread and extrathoracic metastases detected in the majority of patients at initial diagnosis and often shows minimal or no response to conventional chemotherapy. We experienced two pediatric patients...
Original Article
Clinical Study of Post-Traumatic Seizure in Childhood and Adolescence
Jang Weon Moon, Soo Ahn Chae, Dong Keun Lee
Clin Exp Pediatr. 1999;42(2):227-232.   Published online February 15, 1999
Purpose : As morbidity and mortality resulting from physical trauma have significantly increased, the importance of trauma concerning medical, legal, and socioeconomic issues has been widely documented. Studies of post-traumatic seizure after head trauma have been reported, but mostly in adults. So this study was performed to analyse clinical findings on head trauma patients under 20 years of age. Methods :...
A Clinical Study on Lennox-Gastaut Syndrome
Yong Hun Choi, Gyo Dang Koo, Yeong Ho Rah, Sa Jun Chung
Clin Exp Pediatr. 1998;41(5):663-668.   Published online May 15, 1998
Purpose : Lennox-Gastaut syndrome is an intractable epilepsy which is comprised of several types of etiology and generalized seizures. It also combines with mental retardation. The present study was made to ascertain the clinical study on Lennox-Gastaut syndrome in Korea. Methods : From January, 1985 to December, 1995, 31 children, diagnosed with Lennox-Gastaut syndrome at Kyung Hee University Hospital, were analyzed...
Case Report
A Case with Dysphagia Caused by Lower Esophageal Ring in Childhood
Su Eun Park, Hwang Jae Yoo, Cheol Hong Kim, Jae Hong Park
Clin Exp Pediatr. 1997;40(11):1616-1620.   Published online November 15, 1997
Lower esophageal ring is unique disorder of the esophagus. It is composed entirely of mucosal fold, containing no muscle or scar tissue. It is one of the most common causes of dysphagia of adults, but an unusual cause of dysphagia in pediatric age group. This 14-year old male patient experienced progressive dysphagia for several years. Approximately 15 months prior to this visit, he began...
Original Article
A Study on Spirometry Pattern of Normal Children
Hyoung-Shin Lee, Young-Hun Chung
Clin Exp Pediatr. 1997;40(9):1242-1249.   Published online September 15, 1997
Purpose : Pulmonary function test is one of the most important tools in the management of patients with respiratory tract diseases and allergic diseases. In recent years pulmonary function tests have had a wide application in clinical pulmonary diseases. But, there were a few trials of pulmonary function test in normal children. So We performed spirometry-based pulmonary function tests of normal children. Methods : We...
A Clinical Study on the Causes of Childhood Seizures According to the Age
Dong Wook Kim
Clin Exp Pediatr. 1996;39(12):1745-1752.   Published online December 15, 1996
Purpose : Although it is important to know the causes of childhood seizures according to the age, the clinical studies on this topic are rare in Korea. So, I would like to perform this clinical study to evaluate the frequencies of the age-related seizure causes in children. Methods : This study was retrospectively undertaken to evaluate the age and sex distribution,...
A Clinical Evaluation of the Esophagogastroduodenoscopy Studies in Infants and Early Children
Won Jung Shin, Jong Won Shin, Young Ho Ahn, Jin Bok Hwang, Chang Ho Han, Hai Lee Jung, Young Dae Kwon
Clin Exp Pediatr. 1996;39(9):1280-1287.   Published online September 15, 1996
Purpose : Even though the causes and appearance of upper gastrointestinal tract lesions vary with age, attention has seldomly been focused on the infancy and early childhood. This study aimed to provide, as basic material, the experience of esophagogastroduodenoscopy(EGD) in infants and early children. Methods : The objects were 66 patients(male 40, female 26) who underwent EGD examination in case of endoscopic indication at department...
Case Report
Acanthosis Nigricans and TypeII Diabetes in Childhood
In Na Jeong, Hyung Ro Moon
Clin Exp Pediatr. 1996;39(3):404-410.   Published online March 15, 1996
The authors report two cases of type II diabetes with and without a acanthosis nigricans in children and a case of obese child with acanthosis nigricans encountered at Seoul Eul Ji Hospital in 1994 with review of literatures on relationship of obesity, acanthosis nigricans and type II diabetes. In case 1, 14-year old girl, BMI was 24 (weight, 63.5Kg ; height,...
A Case of Castleman's Disease in Childhood
Jong Yoo Lee, Kyung Bae Park, Joon Soo Park, Sang Chul Park, Sang Man Shin, Sang Jhoo Lee, Young Moo Kyu, Ui Han Kim
Clin Exp Pediatr. 1996;39(2):291-295.   Published online February 15, 1996
Castleman's disease(CD) is rare in childhood. It is defined as a localized nodal hyperplasia in mediastinum or cervical area. It is also called angiofollicular lymph node hyperplasia, lymph nodal hamartoma, giant lymph node hyperplasia. It was first described in 1956 by Castleman et al. as a lesion of mediastinal mass. The etiology of CD is not clear. The histologic classification...
Original Article
Prevelance and Associated Factors of Childhood Obesity on the Elementary Students in Kwangju City
Myoung Sook Chung, Yung Il Rho, Eun Gyeoung Jung, Kyung Rye Moon, Sang Gee Park, Young Bong Park, So Yeon Ryu, Jong Park
Clin Exp Pediatr. 1995;38(11):1547-1557.   Published online November 15, 1995
Purpose : The prevalence of childhood obesity and its attendant morbidity have increased and the success of therapy for childhood obesity has been limited. It is important for us to recognize risk factors for the development of obesity in children. The purpose of our study is to provide useful information for the prevention and treatment of childhood obesity. Methods : A...
Case Report
A Case of Cutaneous Polyarteritis Nodosa
Hyun Chul Chae, Kyung Hee Choi, Mi Soo Ahn, Ji Sub Oh
Clin Exp Pediatr. 1995;38(10):1422-1428.   Published online October 15, 1995
Polyarteritis nodosa(PAN), one of the necrotizing vasculitis involving predominantly small and medium sized arteries, is rare disease. PAN may affect many organs such as kidney, heart, liver, gastrointestinal tract, muscles and skin. Cutaneous PAN, a distinct clinical entity, is chronic and benign vascular disease in which cutaneous lesions are predominant with no visceral involvement. We experienced a case of cutaneous PAN in...
Original Article
Characteristics of Childhood Diabetes
Mi Jung Park, Wook Chang, Hyun Chul Lee, Duk Hi Kim, Ho Seoung Kim
Clin Exp Pediatr. 1995;38(8):1116-1123.   Published online August 15, 1995
Purpose : Because of weternized life style, environmental air pollution and infection, the incidence of childhood diabetes is increasing daily. This study was attempted to evaluate charateristics of childhood diabetes. Methods : We evaluated 117 patients diagnosed with Diabetes at Yonsei and Ewha University College of medicine from 1985 to 1994. Results : 1) The majority of patients were diagnosed as IDDM(86%)....