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Original Article
Effect of Hypoxia on Antegrade and Retrograde Atrioventricular Conduction in Isolated Perfused Rabbit Heart
Heon-Seok Han, Young Jun Song, Miran Kang
Clin Exp Pediatr. 2000;43(9):1213-1223.   Published online September 15, 2000
Purpose : Cyanotic congenital heart diseases patients are in a state of hypoxia since birth. In general, hypoxia delays atrioventricular conduction. The atrioventricular node in such a hypoxic condition would have a different function, and some possibility for arrhythmia. The authors studied atrioventricular nodal function during hypoxia to elucidate the relationship between hypoxia and arrhythmia, including atrioventricular node in terms...
Case Report
A Case of Diffuse Aspiration Bronchiolitis in a Dysphagic Infant
Ok Ja Choi, Bong Seong Kim, ung Hye Park, Soo-Jong Hong
Clin Exp Pediatr. 2000;43(6):842-845.   Published online June 15, 2000
Diffuse aspiration bronchiolitis is defined as a clinical entity characterized by a chronic inflammation of bronchioles caused by recurrent aspiration of foreign particles. Clinical symptoms are bronchorrhea, bronchospasm, and dyspnea, and chest radiographs show the presence of regional or disseminated small nodular shadows and hyperlucency. Chest CT should help in detecting diffuse nodular shadows of bronchiolitis. Pathologic findings of diffuse...
Original Article
The Protective Effect of Vitamin E and Desferrioxamine on Cultured Cerebral Neurons of Neonatal Mouse Damaged by Ischemic Condition
So-ra Lee, Yeon-kyun Oh, Seung-taek Park
Clin Exp Pediatr. 1999;42(10):1426-1433.   Published online October 15, 1999
Purpose : Perinatal asphyxia is an important cause of neurologic morbidity. Experiments in animal models of hypoxic-ischemic brain injury demonstrate that brain damage starts during hypoxia-ischemia. In order to evaluate the ischemic condition-induced neurotoxic effect in view of oxi- dative stress, we examined the cytotoxic effect in cultured cerebral neurons of neonatal mouse. Methods : Dissociated cell cultures were prepared...
The Effects of Glutamate Receptor Antagonists on Cultured Cerebral Cortical Neurons of Neonatal Mouse Damaged by Oxidative Stress
Dae-ho Choi, Yeon-kyun Oh, Seung-taek Park
Clin Exp Pediatr. 1999;42(8):1096-1103.   Published online August 15, 1999
Purpose : To evaluate neurotoxic effects induced by oxygen-radicals, which were generated by adding xanthine oxidase(XO) and hypoxanthine(HX), and protective effects of glutamate receptor antagonist such as MK-801 and 6-cyano-7-nitroquinoxaline(CNQX). Methods : Dissociated cell cultures were prepared from cerebrum of neonatal mouse. Tissues were dissected and diced into small pieces in phosphate buffered saline and were incubated at 37℃. Isolated cells...
Cell Proliferation and Apoptosis in Heart of Trisomy 16 in Mice
Eun Jung Bae, Yong Soo Yun, Jung Sun Kim, Jeong-Wook Seo
Clin Exp Pediatr. 1999;42(5):621-630.   Published online May 15, 1999
Purpose : Although abnormal developments of cushion and atrioventricular septum have been suggested, the exact mechanism for the development of atrioventricular septal defect is not well known. We aimed to identify the role of cell proliferation and apoptosis on cardiac morphogenesis in trisomy 16 mice(an animal model for Down's syndrome in human). Methods : We examined the difference in cardiac...
A Study for Causes of Death in Korean Children
Ha Baik Lee, Jun Hee Sul, Young Yull Koh, Jong Wan Kim, Young Jin Hong, Nam Su Kim, Myung Ik Lee
Clin Exp Pediatr. 1998;41(8):1047-1059.   Published online August 15, 1998
Purpose : Analyzing of the causes of childhood death will provide us with the basis to understand prevalent diseases and to make the best possible health plan according to the studies. The National Statistical Office(NSO) of Korea has released an annual report of nationwide death. However, it could have underestimated the death toll of children because of delayed or missing...
Case Report
A Case of Congenital Nephrotic Syndrome due to Diffuse Mesangial Sclerosis
Jung-Jin Yu, Dong Kyu Jin, Hae Il Cheong, Hyun Soon Lee, Yong Choi
Clin Exp Pediatr. 1998;41(3):415-419.   Published online March 15, 1998
Diffuse mesangial sclerosis(DMS) is one of the underlying pathology of congenital and infantile nephrotic syndrome. Infants with DMS develop nephrotic syndrome before 2 years of age and progress to end stage renal disease within 3 years of age. The authors experienced a case of isolated DMS in a 4-month-old male infant who had nephrotic syndrome for 1 month. The diagnosis...
Original Article
The State of Smoking and Alcohol Usein Korean Adolescent
Gi Chan Lee, Young Joon Kim, Young Kyoo Shin, Baik-Lin Eun, Sang Hee Park, Young Chang Tockgo
Clin Exp Pediatr. 1997;40(3):307-317.   Published online March 15, 1997
Purpose : Recently, smoking and alcohol use in adolesecnt have increased and it has been a social issue in Korea.This study was performed to understand the state of smoking and alcohol use in Korean adolescents, and to make abasic data for education of them. Methods : This study was carried in 1994.3,360 students in 13 schools aged from 13 to 18 were enrolled in this...
A Clinical Study on the Causes of Childhood Seizures According to the Age
Dong Wook Kim
Clin Exp Pediatr. 1996;39(12):1745-1752.   Published online December 15, 1996
Purpose : Although it is important to know the causes of childhood seizures according to the age, the clinical studies on this topic are rare in Korea. So, I would like to perform this clinical study to evaluate the frequencies of the age-related seizure causes in children. Methods : This study was retrospectively undertaken to evaluate the age and sex distribution,...
Etretinate Induced Cardiovascular Malformations in Mouse Embryo
Il Kyung Kim, Chang Sung Son, Young Chang Dockgo, Yong Hyuk Jeon
Clin Exp Pediatr. 1995;38(10):1370-1377.   Published online October 15, 1995
Purpose : Etretinate(Tigason? is an aromatic retinoid currently in therapeutic use for psoriasis but studies have shown that it is a potent teratogen in human and in experimental animal. So we carried this study to observe teratogenic effects of etretinate and to search a possibility of etretinate for using as an experimental model to induce cardiovascular malformation. Methods : In order...
Erratum
Three Cases of Necrotizing Lymphadenitis in Childhood
Seong Hoon Hah, Dong Woon Shin, Kyung Hee Lee, Tae Sun Ha, Beom Soo Park, Heon Seok Han, Sang-Hoon Cha, Geon Kook Lee
Accepted January 1, 1970  
Necrotizing lymphadenitis(named as "Kikuchi disease"), initially described by a Japanese pathologist as "a histiocytic necrotizing lymphadenitis with paracortical necrosis, plasmacytoid monocytes infiltration and prominent phagocytic appearance" has been found worldwide. Be-cause of its self-limited course, it has been well known that what should be considered as more important issues are its deatiled pathologic criteria for confirmation and thorough concern about...
Original Article
Clinical Characteristics of Childhood Cerebrovascular Disease and Analysis on the Prognostic Factors
Yong Seung Hwang, Moon Sun Yang
Clin Exp Pediatr. 1995;38(3):353-365.   Published online March 15, 1995
Purpose : Cerebrovascular disease in children is more common than was once recognized and the etiology and prognosis of the disease in children are quite different from those of adults. Recently according to medical reports and clinical experiences, the incidence of childhood cerebrovascular disease is increasing in Korea. To clarify the clinical features of childhood cerebrovascular disease and to analyze its...
House Dust Mites Sensitivity in Korean Atopic children; Correlation between Skin Reaction and Relative Concentration of Specific IgE by ELISA
Ji Hong Kim, Soo Young Lee, Byeung Ju Jeung, Kye Earn Kim, Dong Soo Kim, Ki Young Lee
Clin Exp Pediatr. 1994;37(12):1701-1708.   Published online December 15, 1994
House dust mites, Dermatophagoides farinae and Dermatophagoides pteronyssius, have been identified as the main sources of house dust allergen and are considersed the most important causative allergen in the etiology of allergic respiaratory disease and allergic rhinitis. To evaluate the incidence of positive skin reactivity to house dust mites and relationship between total serum IgE levels and specific IgE antibody to...
Experimental study on the effect of phenobarbital on Na+, K+-activated adenosine triphosphatase in microsome fractions of mouse brain.
Seo Kyu Kim, Sa Jun Chung, Chang Il Ahn
Clin Exp Pediatr. 1991;34(7):959-970.   Published online July 31, 1991
Na+, K+-activated adenosine triphosphatase (Na+, K+-ATPase) is known to play a role as a trigger in neurotransmitter release and may also affect the transport of calcium ion (Ca++). By doing so, Na+, K+-ATPase, as an anticonvulsant, can modify the excitability level of cells in epilepsy. In order to elucidate the possible mechanisms of neuropharmacological interaction between Na+, K+.ATPase and phenobarbital, serial experimental studies were...
Malignant Schwannomas in children.
Joon Jai Kim, Dong Joo Shin, Dong Won Son, Hong Hoe Koo, In Sang Jeon, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(4):525-531.   Published online April 30, 1991
Six pediatric patients who were diagnosed as malignant Schwannoma and treated at Seoul National University Children’s Hospital from Aug. 1981 to Jun. 1990 were reviewed. Mean age was 11 years and 1 month and all cases except one were over 10 years old. Of six cases, three (50%) were associated with von Recklinghausen’s disease. Overall male to female ratio was 1 : 2. In...
Case Report
One Case of Infantile Nephrotic Syndrome.
Byung Hak Lim, Ki Ho Jang, Sang Geel Lee, Im Ju Kang, Sae Kwang Moon
Clin Exp Pediatr. 1985;28(11):1147-1152.   Published online November 30, 1985
We report our experience with a four-month old male infant suffering from nephrotic synrome who developed generalized edema, subsequently associated with progressive uremia. His delivery was uneventful with no history of familiar renal disease. Conservative therapy was started but he expired 26 days after admission. Mesangial sclerotic changes (90% of all glomeruli) with mild compensatory tubular dilatation on the necropsy...
Original Article
Clinical Observation about complications(Especially about Mortality Cases) in Childhood Primary Nephrotic Syndrome.
Hae ll Cheong, Yong Choi, Kwang Wook Ko
Clin Exp Pediatr. 1984;27(3):246-252.   Published online March 31, 1984
Among 350 children who had been admitted to the Ward of Pediatrics, Seoul National University Hospital during the period from 1975.1.1. to 1983.12.31. and had been diagnosed as idiopathic nephrotic syndrome, total 21 cases (6%) had expired or had progressed into end stage renal disease during follow-up. Among these, 13 cases(61.9%； Group A) had expired due to chronic renal failure...
Clinical and Statistical Obervation of Sick Babies in SCBU.
Kyung Tae Kim, Dae Sik Hong, Kew Taek Kim
Clin Exp Pediatr. 1981;24(1):24-35.   Published online January 15, 1981
Clinical and statistical analysis were performed on 573 cases of neonates who were admitted in the special care baby unit, St. Benedict Hospital, from January 1978 to June 1979. The results were as following: 1) Sex ratio of male to female was 1.04:1. 2) According to the route of admission, The ratio of "non-referred patients" to "referred patients was 1.86:1....