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Review Article

Seokyung Hahn

Clin Exp Pediatr. 2012;55(11):403-407. Published online November 23, 2012

Noninferiority trials test whether a new experimental treatment is not unacceptably less efficacious than an active control treatment already in use. With continuous improvements in health technologies, standard care, and clinical outcomes, the incremental benefits of newly developed treatments may be only marginal over existing treatments. Sometimes assigning patients to a placebo is unethical. In such circumstances, there has been...

DOI: https://doi.org/10.3345/kjp.2012.55.11.403

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