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Volume 41(2); Feb 1998
Clinical Lecture
Failure to Thrive
Sei Won Yang
J Korean Pediatr Soc. 1998;41(2):147-153.   Published online February 15, 1998
Original Articles
Developmental mRNA Expression of Cellular Retinoic Acid Binding Protein I and Ⅱ in Rat
Young Yoo, Hyung Suk Kim, Chang Sung Son, Young Chang Tockgo, Young Hyuk Jeon
J Korean Pediatr Soc. 1998;41(2):154-162.   Published online February 15, 1998
Purpose : Retinoic acid(RA) is well known as a potent teratogenic agent in both deficiency and excess. Cellular retinoic acid binding proteins(CRABPs) are involved in RA. We carried this study in order to determine the possible relations of CRABPs with RA-induced teratogenesis through observation of the expression patterns of CRABP Ⅰand Ⅱ in developing rats. Methods : 35S-labeled RNA probes were...
Congenital Asymptomatic Cytomegalovirus Infection; A Comparison of Specific IgM Antibody Test and pp65 Antigenemia Assay
Jong Hyun Kim, Eun Ah Seo, Ji Hyang Lim, Sang Hee Park, Won Bae Lee, Kyong Su Lee, Sin Ho Jung
J Korean Pediatr Soc. 1998;41(2):163-169.   Published online February 15, 1998
Purpose : It is increasingly important to diagnosis asymptomatic infections which make up a majority(90%) of congenital cytomegalovirus(CMV) infections and that they may have sequeles such as sensorineural hearing loss and mental retardation. Recently antigenemia assay has been developed by using monoclonal antibodies against early structural protein pp65 of CMV. This CMV antigenemia assay seems to be more quicker to...
Humoral and Cell Mediated Immune Response After Immunization with Varicella Vaccine(Oka/LG)
Young Mo Sohn, Hye Ok Roh, Mi Lim Goo, Bok Ryeon Park, Joo Hong Park, Gook Jin Lim
J Korean Pediatr Soc. 1998;41(2):170-178.   Published online February 15, 1998
Purpose : We evaluated the humoral and cellular immune response to varicella-zoster virus after vaccination with varicella vaccine(Oka/LG strain). Methods : The seroprevalence rate of fluorescent antibody to membrane antigen(FAMA) was evaluated among 178 children and 15 adults. After vaccination, seroconversion rate of FAMA, varicella-zoster virus(VZV) specific IgG and cell mediated immune response to glycoprotein Ⅰwas performed. Results : The seropositive rate...
Efficacy of Mycoplasma Antibody Test and Cold Agglutinin Test in the Diagnosis of Mycoplasma Pneumonia in Children
Jung Ae Son, Weon Par, Dong Jin Lee
J Korean Pediatr Soc. 1998;41(2):179-185.   Published online February 15, 1998
Purpose : This study was done to compare the diagnostic value of the Mycoplasma antibody (M- Ab) test and the cold agglutinin(CA) test from the onset of Mycoplasma pneumoniae pneumonia to its diagnosis in children. Methods : We analyzed 48 cases of M. pneumoniae pneumonia in children who were admitted to the Pediatric Department of Ulsan Dongkang General Hospital for 1...
Treatment of Supraventricular Tachycardia by Catheter Ablation Using Radiofrequency Currents in Children and Adolescents
Sung Jae Lee, Mi Jin Jung, Dieter Gonska
J Korean Pediatr Soc. 1998;41(2):186-191.   Published online February 15, 1998
Purpose : Catheter ablation using radiofrequency currents have been proven to be an effective and safe tool for the treatment of adult patients with accessory atrioventricular pathways. This study was designed to analyze the efficacy of this method in childern and adolescents. Methods : Using radiofrequency currents, cathether ablation of an accessory pathway was performed in 54 patients(mean age 11.8 years)...
Left Ventricular Mass Estimated by Three Methods of Echocardiography in Normal Children
Yae Jean Kim, Soo Ja Hwang, Dong Hee Shin, Young Mi Hong
J Korean Pediatr Soc. 1998;41(2):192-199.   Published online February 15, 1998
Purpose : Left ventricular hypertrophy is an important diagnostic and prognostic finding in children with various cardiovascular diseases. Echocardiographic determination of the left ventricular mass is the most accurate method for assessing left ventricular hypertrophy non-invasively. The purposes of this study are 1) to establish a reproducible, validated method for determining left ventricular mass in children by echocardiography, 2) to...
Serum Pepsinogen Ⅰ, Ⅱ Levels and Upper Gastrointestinal Diseases in Children with H. pylori Infection
Je Woo Kim, Ki Sup Chung
J Korean Pediatr Soc. 1998;41(2):200-208.   Published online February 15, 1998
Purpose : In H. pylori infection serum pepsinogen Ⅰ/Ⅱ ratio decreases and pepsinogen Ⅱ level is increased. Increased serum pepsinogen Ⅱ level correlates with pathologic severity of gastritis. We assayed serum pepsinogen Ⅰ, Ⅱ levels and pepsinogen Ⅰ/Ⅱ ratio to evaluate the relationship between the serum pepsinogen level and upper gastrointestinal diseases. Methods : One hundred and sixty-five children who had...
Induction Chemotherapy with BH-AC, Idarubicin, and 6-Thioguanine in Childhood Acute Myelogenous Leukemia
Hyo Jeong Han, Hyoung Jin Kang, Jun Ah Lee, Hyoung Soo Choi, Hyeon Jin Park, Ki Woong Seong, Eun Sun Yoo, Hee Young Shin, Hyo Seop Ahn
J Korean Pediatr Soc. 1998;41(2):209-215.   Published online February 15, 1998
Purpose : We have undertaken this study to evaluate the effects of induction chemotherapy involving BH-AC, idarubicin, and 6-thioguanine(6-TG). Methods : BH-AC 300mg/m2/day was administered intravenously over three hours for seven consecutive days. Idarubicin 12mg/m2/day was administered intravenously for three days. 6-TG 100 mg/m2/day was administered orally for seven days. Intrathecal ara-C was administered on the first day of treatment. Results...
High Dose of Amphotericin B in Intralipid Emulsion-based Delivery System in Immunocompromised Children with Invasive Fungal Infections
Geun Mo Kim, Hoon Kook, Sung Ho Cho, Ji Yong Park, Young Jong Woo, Tai Ju Hwang
J Korean Pediatr Soc. 1998;41(2):216-223.   Published online February 15, 1998
Purpose : Fungal infections are an important cause of morbidity and mortality in patients with hematologic malignancies. The therapy of choice in documented or suspected invasive fungal infections has been intravenous Amphotericin B(AmB). Adverse effects such as fever, chills, thrombophlebitis, nausea or vomiting are common. A more serious adverse effect is potential renal impairment. As AmB administration mixed with Intralipid(AmB/Intralipid)...
Etiological Analysis of Gynecomastia in Children
Jai Keun Kim, Ki Keun Oh, Choon Sik Yoon, Jae Hyun Park
J Korean Pediatr Soc. 1998;41(2):224-229.   Published online February 15, 1998
Purpose : The purpose of this study is to analyze the etiology of gynecomastia confirmed by breast operation among children under the age of 15 exhibiting clinical symptoms. Methods : Twenty patients under the age of 15 were diagnosed as having gynecomastia in the past 10 years. The number of pathologically confirmed gynecomastia patients was 15. The causes or related...
The Diagnostic Significance of MCV, MCH, and RDW in Anemia of Kawasaki Disease
Ji Eun Lee, Yoon Hyung Park, Seung Baik Han, Soon Ki Kim, Sei Woo Chung, Jeung Gyu Kim, Byong Kwan Son
J Korean Pediatr Soc. 1998;41(2):230-236.   Published online February 15, 1998
Purpose : We investigated what kind of factors are the most stable among hemoglobin(Hb), hematocrit(Hct), MCV, MCH and RDW as a marker of discriminating anemia due to an acute inflammation from anemia of different origins. Methods : We evaluated 141 patients with Kawasaki disease who had been admitted to the Department of Pediatrics, Inha hospital from 1990 to 1995. We...
The Effect of Acanthopanax koreanum Extract on the Induction of Collagen Induced Arthritis for DBA/1J Mice
Dong Soo Kim, Chang Ho Song, Soo Kon Lee
J Korean Pediatr Soc. 1998;41(2):247-254.   Published online February 15, 1998
Purpose : It is well known that the Acanthopanax koreanum extract has an anti-inflammatory action without any adverse effects reported. We conducted this study to see whether the Acanthopanax koreanum extract has a preventive effect on the development of collagen induced arthritis in DBA/1J mice. Methods : Three groups of BDA/1J mice were immunized by intradermal injection of 2mg/kg bovine type...
Case Reports
A Case of Trisomy 9 Syndrome
yu Sik Jeon, Heung Tak Kim, Soon Hee Jeong, Kyuchul Choeh
J Korean Pediatr Soc. 1998;41(2):255-258.   Published online February 15, 1998
Since Feingold and his collegues first describes the trisomy 9 syndrome in 1973, approximately 30 patients with trisomy of the chromsome 9 have been described. Trisomy 9 has been reported as either partial or complete. Complete trisomy is rare and incompatible with a a long life. Before this report, this syndrome has not been reported in Korea. A neonate was diagniosed...
A Case of Slowly Progressing Aneurysm of Left Ventricle and Thoracic Aorta Due to Automobile Blunt Trauma
Eun Ju Kim, Yu Sik Jeon,, Kyuchul Choeh, Jae Kyun Shin, Jeong Tae Ahn, Dong Man Seo
J Korean Pediatr Soc. 1998;41(2):259-263.   Published online February 15, 1998
A five-year-old boy received a blunt trauma on chest by a kindergarten bus on Feb. 29, 1996. Pulmonary hemorrhage and pericardiac effusion were developed, followed by multi-organ failure threatening his life. All symptoms were improving when pansystolic harsh murmur(Ⅲ/Ⅵ) originating from a tiny ventricular rupture with a blood leak to the pericardial space was auscultated on the 12th day after the...
A Case of Multiple Sclerosis
Young Hee Ha, Jong Hyun Kim, Soo Joong Lee, Dae Kyun Koh
J Korean Pediatr Soc. 1998;41(2):264-269.   Published online February 15, 1998
Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system and its lesions are multiple in time as well as space. We experienced a case of a 14-year-old-girl with dysphagia, paresthesia and headache. Brain MRI scans demonstrated high signal intensities on T2-weighted images at the medulla and upper cervical cord. Acute disseminated encephalomyelitis was diagnosed and methylprednisolone pulse...
A Case of Hypernatremia due to Esophageal Foreign Body
Won Bae Kim, Jung Hee Kang, Soo Kyung Lee
J Korean Pediatr Soc. 1998;41(2):270-274.   Published online February 15, 1998
Hypertonic or hypernatremic dehydration, which is uncommon in pediatric patients beyond infancy, has a distinct pathophysiology that differentiates the clinical presentation and management from other forms of dehydration. Severe hypernatremia may precipitate central nervous system injury, seizures, intracerebral bleeding, retardation, and even death. Causes of hypernatremia include inadequate water intake, salt overload, extrarenal water loss, defective osmoregulation, and water loss...
A Case of Type A Niemann-Pick Disease
Eun Young Jeon, Kyung Ah Choi, Chul Hoe Koo, Wha Mo Lee, Young Suk Jeon, Chang Hun Lee, Kang Suek Suh, Sun Kyeung Lee
J Korean Pediatr Soc. 1998;41(2):275-280.   Published online February 15, 1998
Niemann-Pick disease is a storage disease characterized by accumulation of sphingomyelin and other lipids, mainly in the reticuloendothelial system. We experienced a case of type A Niemann-Pick disease in a 18-month-old male infant. He showed dyspnea, marked hepatosplenomegaly and developmental retardation. Fundoscopic examination revealed cherry red spots in both macula. Bone marrow aspirates showed characteristic foam cells. Autopsy finding revealed...
A Case of Genital Prolapse in Premature Baby
Woong Kyu Choi, Seung Cheol Lee, Yong Won Park, Chong Guk Lee, Sang Woo Kim
J Korean Pediatr Soc. 1998;41(2):281-284.   Published online February 15, 1998
Neonatal genital prolapse is very rare and is usually associated with meningomyelocele or other anomalies of the central nervous system. Synonyms of genital prolapse are sacropubic hernia, pelvic relaxation, and pelvic organ prolapse. There are two types of genital prolapse including vaginal prolapse and uterovaginal prolapse. We experienced a case of uterovaginal prolapse in a 30 day-old premature infant, which...
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