Clinical and Experimental Pediatrics

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Seong Ryong Lee

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Original Article

Neonatology (Perinatology)

Effects of carnosine and hypothermia combination therapy on hypoxic-ischemic brain injury in neonatal rats

Jun Chul Byun, Seong Ryong Lee, Chun Soo Kim

Clin Exp Pediatr. 2021;64(8):422-428. Published online February 24, 2021

Web of Science 5 Crossref 6

Question: How can we further improve the neuroprotective effects of hypothermia in newborns with hypoxic-ischemic (HI) brain injury?
Finding: Combination carnosine and hypothermia therapy effectively reduced brain damage in neonatal rats. The in situ zymography, terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay, and immunofluorescence study results showed that neuroprotective effects were achieved with combination therapy only.
Meaning: Carnosine and hypothermia have synergistic neuroprotective effects against brain damage following HI injury

DOI: https://doi.org/10.3345/cep.2020.01837

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