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Original Article

Nephrology (Genitourinary)

Impaired angiogenesis in the enalapril-treated neonatal rat kidney

Hyung Eun Yim, Kee Hwan Yoo, Eun Soo Bae, Young Sook Hong, Joo Won Lee

Clin Exp Pediatr. 2016;59(1):8-15. Published online January 22, 2016

Crossref 6

Purpose

Nephrogenesis is normally accompanied by a tightly regulated and efficient vascularization. We investigated the effect of angiotensin II inhibition on angiogenesis in the developing rat kidney.

Methods

Newborn rat pups were treated with enalapril (30 mg/kg/day) or vehicle (control) for 7 days after birth. Renal histological changes were checked using Hematoxylin & Eosin staining. We also investigated the intrarenal expression of vascular...

DOI: https://doi.org/10.3345/kjp.2016.59.1.8

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