Clinical and Experimental Pediatrics

Original Article

General Pediatrics

Effect of varicella vaccine introduction on chickenpox incidence in Kingdom of Bahrain

Afaf Merza Mohamed, Hasan M. Isa, Malak Husain Hasan, Maram Husain Hasan, Ali K. Moosa, Janan Husain Radhi, Basma Al Saffar, Adel Al Sayyad

Clin Exp Pediatr. 2026;69(11):868-877. Published online September 14, 2026

Question: What was the effect of varicella vaccine introduction on chickenpox incidence in Bahrain?
Finding: Postvaccine introduction in May 2015, new varicella cases declined substantially, particularly among children aged 0–9 years. Most cases are managed in primary healthcare settings, with rare hospitalizations and no reported deaths.
Meaning: Routine varicella vaccination is associated with reduced disease burden, demonstrating sustained high coverage, continued surveillance, and protection of susceptible groups.

DOI: https://doi.org/10.3345/cep.2026.01326

Gastroenterology

Assessing indicators and clinical differences between functional and organic childhood constipation: a retrospective study in pediatric gastroenterology clinics

Hasan M. Isa, Fatema A. Alkharsi, Fatema A. Salman, Maryam S. Ali, Zahra K. Abdulnabibi, Afaf M. Mohamed

Clin Exp Pediatr. 2023;66(7):296-306. Published online June 14, 2023

Web of Science 3 Crossref 4

Question: What causes childhood constipation, and what can predict organic constipation?
Finding: Constipation represents 14.7% of gastroenterology visits. Functional constipation is more common among constipation types, while organic constipation is more common in young children and those with a low body weight, stunted growth, mucus in the stool, and associated diseases.
Meaning: Younger children and those with lower growth or mucus in the stool should be assessed for underlying organic causes of constipation.

DOI: https://doi.org/10.3345/cep.2022.01298

Celiac disease in children: Increasing prevalence and changing clinical presentations

Hasan M. Isa, Eman Farid, Jaafar J. Makhlooq, Afaf M. Mohamed, Jumana G. Al-Arayedh, Fawzeya A. Alahmed, Shima Medani

Clin Exp Pediatr. 2021;64(6):301-309. Published online October 17, 2020

Web of Science 5 Crossref 7

Question: What are the prevalence and clinical characteristics of celiac disease (CD) in children in Bahrain?
Finding: We found a significant increase in CD prevalence over the last decade (P=0.0001). A male predominance was noted. Atypical presentations were common. Most patients had poor adherence to a gluten-free diet.
Meaning: CD is an underdiagnosed condition. Atypical symptoms should be considered to prevent missing patients with CD.

DOI: https://doi.org/10.3345/cep.2020.00304

Genetics and Metabolism

Neonatal indirect hyperbilirubinemia and glucose-6-phosphate dehydrogenase deficiency

Hasan M. Isa, Masooma S. Mohamed, Afaf M. Mohamed, Adel Abdulla, Fuad Abdulla

Clin Exp Pediatr. 2017;60(4):106-111. Published online April 25, 2017

Crossref 19

Purpose

This study aimed to determine the prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency among infants with neonatal indirect hyperbilirubinemia (NIH); compare G6PD-deficient and G6PD-normal patients regarding hyperbilirubinemia and need for exchange transfusions (ET); and assess risk factors for ET and kernicterus.

Methods

This is a case-control retrospective study. Medical records of NIH patients admitted to the Pediatric Department, Salmaniya Medical Complex, Bahrain, between...

DOI: https://doi.org/10.3345/kjp.2017.60.4.106

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