Although high morning blood pressure (BP) is known to be associated with the onset of cardiovascular events in adults, data on its effects in children with hypertension are limited. Our retrospective study aimed to define the clinical characteristics of children with morning hypertension (MH) and to determine its associated factors. We reviewed 31 consecutive patients with hypertension, confirmed by the ambulatory... |
The aim of this study was to determine whether school-aged children with Kawasaki disease (KD) have an increased risk for early atherosclerosis. The study included 98 children. The children were divided into the following groups: group A (n=19), KD with coronary arterial lesions that persisted or regressed; group B (n=49), KD without coronary arterial lesions; and group C (n=30), healthy children.... |
Purpose : We evaluated the diagnostic implications and therapeutic efficacy of antithrombin III(AT III) in the disseminated intravascular coagulation(DIC) of premature infants. Methods : Ninety-two premature infants diagnosed with DIC and treated with AT III from March, 2000 to May, 2003 were retrospectively reviewed. Clinical manifestations, complete blood counts, coagulation tests, and AT III levels were compared between the two groups... |
Purpose : We investigated the hormonal control of OB gene expression and leptin secretion in cultured human visceral adipose tissue. Methods : Visceral adipose tissues were cultured for up to 48 hrs in modified Eagle's medium with varying concentration of hormones : Control(no hormone), bovine insulin(100 nM), Dexamethasone(DEX, 100 nM), growth hormone(GH, 40 ng/mL), insulin+DEX(100 nM each), insulin+DEX+GH(100 nM insulin... |
Purpose : Long-term administration of anticonvulsants for pediatric epileptic patients may cause changes of bone metabolism. This study was performed to evaluate the influence of antiepileptics on the bone metabolism and growth in pediatric patients who received antiepileptics. Methods for early detection of adverse bone metabolism were also evaluated. Methods : Forty-eight epileptic patients were enrolled in this study.... |
Purpose : Thawed stem cells should be infused as early as possible because delay of infusion leads to decrease of cell viability and formation of DNA clumping. The procedure of 10% Dimethyl sulfoxide(DMSO) removal and a long distance from the thawing location to the patient are the main causes of delay of infusion that results in the loss of cell... |
Multicystic encephalomalacia is the condition defined anatomically by the presence of multiple cavities in the great part of both cerebral hemispheres. The most common cause of the condition was regarded as the circulatory disturbance during the perinatal period. Also,neonatal asphyxia was the most important cause of the circulatory disturbance. But we experienced a case of multicystic encephalomalacia in a liveborn twin with a stillborn... |
Purpose : Varicella is mild self limited disease with vesicular skin eruption but highly contagious and accompanied many complications. Especially, varicella is fatal in leukemic children and immunocompromised children. The live varicella zoster virus was first developed by Takahashi et al. in the 1974. This vaccine has now been licensed for general use in Europe and the United States as well as in Korea.. The... |
We experenced a case of cystic pancreatoblastoma associated with congenital hemihypertrophy in a 4months old male. The mass was located on the anterior side of pancreatic head without any connection to the pancreas. After exision of cystic pancreatoblastoma, chemotherapy(FAM regimen) was performed 15 times due to capsular tumor invasion. Until this time there was no drug side effect and metastasis.... |
Purpose : With PDA, major fluctuations of blood flow are noted between opening and closure of ductus arteriosus and there is an increase in the amplitude of each pulse of blood flow. The purpose of this study was to evaluate the changes of cerebral blood flow before and after closure of ductus arteriosus in healthy term newborns. Methods : Forty-two normal term... |
Purpose : We tried to know normal range of auditory brainstem responses in premature and fullterm infants who have no rksk factor during perinatal period and to determine that the abnormal ABR in premature and fullterm infants may predict developmental delay. Methods : ABR evaluations were performed on 283 premature and fullterm infants from NICU of the Asan Medical Center during... |
Purpose : Stable microbubble rating test(SMR) plays an important role in the clinical course and the prognosis of respiratory distress syndrome(RDS) patients, because SMR can be easily performed and it can predict quickly the neonatal RDS. After the success of the pulmonary surfactant replacement therapy in RDS infants by Fujiwara and co-workers in 1980, many supporting studies were presented and... |
Glycogen storage disease(GSD) type Ⅰis due to defect of glycose-6-phosphatase at the membrane of the endoplasmic reticulum in liver. Clinical presentations of GSD 1 are massive hepatomegaly without splenomegaly, failure to thrive, bleeding tendency, hypoglycemia, fasting ketosis and hyperlipidemia. The appearance of patient is short and fat with particularly fat cheeks. Mental development is usually normal. It was diagnosed by... |
Purpose : Acquisition of varicella by the neonate as a result of congenital varicella-zoster infection or exposure during delivery is well known. And it generaly believed that infants under 6 months of age may acquire varicella more frequently than other viral infections such as measles. However, little if known about immune mechanism of varicella-zoster infection. Transfer maternal antibodies to this... |
Exercise induced asthma(EIA) is defined as acute, reversible, usually self-immiting airway obstruction which develop after strenous exercise in patients with asthma. EIA is a bigger problem in children than adults due to more active and smaller airways which obstruct more easily when bronchospasm develops. The exercise elicited amny change in pulmonary function of asthmatic children. These change could be measured... |
T cell lymphoblastic lymphoma is characterized by immature lymphoid cells that are indistinguishable from the lymphoblasts and prolymphocytes of acute lymphoblastic leukemia. Several characteristic clinical features of lymphoblastic lymphoma, with include a high male-to-female ratio, a relatively high incidence in older children and young adults, the frequent presence of mediastinal involvement at the time of diagnosis. Also, this disease is... |
The author investigated serum immunoglobulin (IgG, IgA, and IgM) and complements (C3) of cord blood in 74 cases of normal fulterm infants and 50 cases of premature infants. Serum immunolglobulin and complement levels were measured by the single radial immunodiffusion method. The following results were obtained ; 1) The mean serum IgG levels of cord blood in 74 cases of the normal... |
The paramount importance of breast feeding for the health of the infants has been recognized by nutritionists and physicians. Although many advantages of the breast feeding, exclusive breast feeding without weaning diet or supplement food during prolonged period in infants may produce iron deficiency anemia. This study was conducted to find out the hematologic state in exclusively prolonged breast-fed infants among... |
The authors studied 25 cases with urinary tract infection associated with vesicoureteral reflux who were admitted to department of pediatrics, National Medical Center. The patients were managed medically or surgically and followed up. The results were summarized as follows; 1) There were no difference in age and sex distributions of the 25 cases with vesicoureteral reflux. 2) The degree of reflux classified by International... |
Agenesis of the lung is a developmental defect with complete absence or profound hypoplasia of one or both lung : absence of one lung is more common. Absence of both lung is very rare and is incompatible with life. Unilateral or bilateral agenesis of the lung often associated with the skeletal, cardiovascular, gastrointestinal and genitourinary anomalies. H-type tracheoesophageal fistula in... |
A clinical observation according to the age of onset was made on 40 children with Reye syndrome who had been admitted to pediatric department of National Medical Center during 11 year period from January 1979 to December 1989. 1) Annual distribution showed the largest number in 1982. There was no significant difference in seasonal distribution. 2) Cases of infant comprised 22 (55.0%)... |
We measured the degree of immunity of 155 childrens with the age from birth to 12 years to measles antibody titer by enzyme-linked immunosorbent assay (ELIZA) for determine the proper age the Measles vaccination. The results were as follows; 1) By age group, 64% of the children was positive for Measles IgG antibody with the age between 1 and 2 months and 17% of the children with... |
Thirty three from 689 children (4.79%) who were screened among hospitalized patients from July, 1986 to June, 1988, were positive for hepatitis B surface antigen in their serum sample tested by radioimmunoassay. The positive rate of hepatitis B surface antigen was 3.04% when the hepatitis patients were excluded. The incidence of hepatitis B surface antigen was higher (5.18%) in male than in famale (4.17%)... |
In this prospective study, the relation between the Apgar scores and umbilical arterial pH at birth was assessed. 314 newborns of gestational age 24 to 42 weeks were included in this study; (95 were preterm and 219 were full-term) The l and 5-minute Apgar scores were directly related to gestational age. In preterm babies, the Apgar scores tend to be low in spite... |
A clinical study was performed on 26 cases of pulmonary air leaks in the newborn who were admitted to the NICU of National Medical Center from Jan. 1984 to Aug. 1988 The results were as follows: 1) Spontaneous air leaks were 2 cases (7.7%)and secondary air leaks were 24 cases (92.3%). 2) Of the 26 cases of pulmonary air leaks, 13 cases (50.0%) had meconium aspiration... |
Modem medical science has been developed advanced rapidly in the past years, but congenital anomalies are known as a major cause of neonatal death. So, we studied the incidence of congenital malformations among 11,119 babies deliveried or admitted at EWUH during a period of five years starting from June 1983. The results were as follows: 1) The incidence of congenital malformations among 11,119 deliveries was 1.5%(1.5%... |
Transient myeloproliferative disorder has been reported in infant with Down's syndrome during neonatal period. This is clinically and hematologically indistinguishable from congenital acute leukemia. In contrast to congenital leukemia, complete clinical and hematological recovery occurs within weeks to months of diagnosis without antileukemic treatment. A neonate presented with jaundice, hepatosplenomegaly and mongoloid face was diagnosed as Transient myeloproliferative disorder. We report this case with a review of... |
We observed 42 cases of neonates, who were diagnosed as having Hyaline membrane disease and had been received mechanical ventilation in neonatal intensive care unit of Presbyterian medical center from July 1984 to July 1988. In order to observe the factors associated with pneumothorax, we devide these cases in two groups. First group was consists of infants with pneumothorax, second group was consists of... |
Dandy-Walker syndrome is a developmental disorder of the brain associated with hydrocephalus, possterior fossa cyst and maldevelopment of the cerebellar vermis and is a result of outlet obstruction of the fourth ventricle. We experienced a case of a 6 day old male neonate who presented macrocephaly which revealed marked dilated fourth & lateral ventricle, large posterior fossa cyst and hypoplastic cerebellum, no vermis on Brain... |
We experienced a case of Cockayne syndrome in a 12 10/12 year-old male who had characteristic manifestations with cachectic dwarfism, severe mental retardation, intracranial calcifications, an unusal face, photo-sensitive dermatitis and joint flexion contractures. Laboratory investigations have not revealed any consistent abnormality. We report this case with brief review of some related literatures. |