Clinical and Experimental Pediatrics

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Original Article

Infection

Evolving treatment strategies for invasive Streptococcus pyogenes in children in the postpandemic era

Laura Buricchi, Giuseppe Indolfi, Marco Renni, Elisabetta Venturini, Luisa Galli, Elena Chiappini

Clin Exp Pediatr. 2025;68(11):921-931. Published online August 11, 2025

Crossref 1

Question: What are the roles of linezolid, intravenous immunoglobulin (IVIG), and corticosteroids in pediatric invasive group A streptococcal infection (iGAS)? Can any improve outcomes beyond beta-lactams and clindamycin?
Finding: Two of 46 patients with iGAS died. Nearly all received beta-lactams plus clindamycin. Linezolid was effective in refractory cases. IVIG and corticosteroids had variable efficacies.
Meaning: Linezolid may be valuable in refractory cases. IVIG may be considered in severe presentations. The role of corticosteroids remains less clearly defined.

DOI: https://doi.org/10.3345/cep.2025.00479

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