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Original Article

Less invasive surfactant administration versus intubation-surfactant-extubation: a single-center retrospective study

C.S. Jithin, A. Nalina, A. Shashidhar, P.N. Suman Rao

Question: Does less invasive surfactant administration (LISA) (vs. intubation-surfactant-extubation) improve clinical outcomes in preterm infants with respiratory distress syndrome?
Finding: LISA significantly reduced intubation and invasive mechanical ventilation needs within the first 72 hours and shortened the overall invasive respiratory support duration without increasing other morbidities.
Meaning: LISA is a less invasive and safer surfactant delivery alternative. Larger multicenter trials are needed to confirm its long-term safety and efficacy, especially in low- and middle-income countries.

DOI: https://doi.org/10.3345/cep.2025.00332 [Epub ahead of print]

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