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Original Article

Plasma Levels of Oral Methotrexate in Children Receiving Maintenance Chemotherapy for Acute Lymphocytic Leukemia

Soo Kwan Lee, Kih Yeon Song, Young Hee Hwang, Young Hwan Lee, Jeong Ok Hah, Chun Dong Kim

Clin Exp Pediatr. 1993;36(7):936-943. Published online July 15, 1993

This study was conducted to investigate plasma levels of oral methotrexate in rabbits and children receiving maintenance chemotherapy for acute lymphocytic leukemia. Eight New Zealand white rabbits, weighing 2kg in body weight, were divided into 3 groups and 5mg of methotrexate from 3 different manufactorying company was administered to the each group rabbits via nasogastric tube. Time to peak concentration ranged from...

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