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Original Article
Can a basophil activation test of cord blood predict a cow's milk allergy?
Dilara Fatma Kocacık Uygun, Durmuş Burgucu, Vedat Uygun, Gül Alkan Bülbül, Fulden Duyar, Cem Yaşar Sanhal, Ayşen Bingöl
Background: Food allergies affect 4%–6% of the pediatric population and are often present within the first 2 years of life. Cord blood cells and cytokines in high-risk infants can predict allergic problems; however, their predictive value remains unclear.
Purpose: This study aimed to determine whether a cow's milk allergy in infants can be predicted using a basophil activation test (BAT) of cord blood samples by stimulating basophils with...
Hematology
Hematopoietic stem cell transplantation in pediatric patients with type VI mucopolysaccharidosis
Vedat Uygun, Koray Yalçın, Hayriye Daloğlu, Seda Öztürkmen, Suna Çelen, Suleimen Zhumatayev, Gülsün Karasu, Akif Yeşilipek
Clin Exp Pediatr. 2025;68(8):601-607.   Published online March 11, 2025
Question: Could hematopoietic stem cell transplantation (HSCT) be an alternative to enzyme replacement therapy (ERT) for type VI mucopolysaccharidosis (MPS VI)?
Finding: HSCT is generally not offered due to reports of high toxicity and mortality. However, we detected fewer complications and graft-versus-host disease cases and no deaths with HSCT.
Meaning: HSCT is both less expensive than ERT and permanent; thus, it should be considered an alternative treatment for MPS VI.


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