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Purpose : Adriamycin is very important in cancer chemotherapy. Unfortunately, the drug shows
cumulative dose dependent cardiotoxicity. The precise mechanism of this remains unclear. It has
been shown that adriamycin induces programmed cell death or apoptosis in many tissues. But the
role of apoptosis in adriamycin induced cardiotoxicity is uncertain.
Methods : Sprague-Dawley rats were divided into four groups of ten animals each. All... |
