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Original Article

Effects of Adriamycin on Membrane Potential and Intracellular Sodium Activity in Canine Purkinje fibers

Chan Uhng Joo, Soo Wan Chae

Clin Exp Pediatr. 1992;35(8):1107-1112. Published online August 15, 1992

Anthracycline antibiotic adriamycin (doxorubicin) is presently considered to be a very effective chemotherapeutic agent in the treatment of many human tumors. Adriamycin induced cardiomyopathy limits its clincal use. A number of hypotheses have been proposed to explain the mechanism of cardiotoxicity with adriamycin, but none has yet been demonstrated. The effects of adriamycin on membrane potential and intracellular sodium ion...

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