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Human atrial myocytes secrete atrial natriuretic peptides (ANP) into the plasma, which causes
rapid and marked natriuresis, diuresis and vasorelaxation. The releases of renin, aldosterone, and
antidiuretic hormone are inhibited by ANP in vivo and in vitro experiments. Various atrial natriur-
etic peptides were isolated and synthesized. Plasma ANP concentrations usually elevated in conges-
tive heart failure, chronic renal failure, pulmonary arterial hypertension, tachyarrhythmia,... |
