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Original Article

TNF-α stimulated IL-8 and IL-10 expression in monocytes from patients with chronic granulomatous disease

Kyung-Sue Shin

Clin Exp Pediatr. 2008;51(10):1096-1101. Published online October 15, 2008

Purpose : Patients with chronic granulomatous disease (CGD) have genetic mutations in a component of the NADPH oxidase enzyme that is necessary for the generation of the superoxide anion. The profound defect in innate immunity is reflected by the patients susceptibility to catalase-positive bacteria and fungi. In addition, CGD patients display signs of persistent inflammation, which is not associated only...

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