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Review Article
The management and treatment of chronic hepatitis B in Korean children
Byung-Ho Choe
Clin Exp Pediatr. 2007;50(9):823-834.   Published online September 15, 2007
Interferon (IFN) alpha has been the first line therapy of chronic hepatitis B in children, but HBeAg seroconversion occurred in 26% of treated children compared to 11% of controls in multinational randomized controlled study. Recently, lamivudine was shown to be a potent inhibitor of Hepatitis B virus (HBV) reproduction both in HBeAg positive and in HBeAg negative (the pre-core mutant...
Original Article
Comparison of Therapeutic Efficacy between Lamivudine and Alpha-Interferon in Korean Children with Chronic Hepatitis B at Two Years after the Initiation of Treatment
Byung-Ho Choe, You Cheol Jang, Chang Hwan Jang, Ki Won Oh, Jun Hwa Lee, Cheol Woo Ko
Clin Exp Pediatr. 2005;48(1):55-62.   Published online January 15, 2005
Purpose : We compared the therapeutic efficacy of lamivudine and alpha-interferon in children with chronic hepatitis B two years after the initiation of treatment, so that we could verify the safety and long term efficacy of lamivudine in children. Methods : We prospectively studied 44 children(32 male and 12 female; age, 1-18 years, mean, 9 years) treated for chronic hepatitis B...
Natural History of Chronic Hepatitis B in Children
Yuria Kim, Seoung Yeon Baek, Ji Hyun Eom, Ki Sup Chung
Clin Exp Pediatr. 2004;47(3):282-289.   Published online March 15, 2004
Purpose : We investigated the spontaneous seroconversion rate of hepatitis B viral markers and predictive factors affecting seroconversion in children with chronic hepatitis B. Methods : The study population included 214 children diagnosed as chronic hepatitis B, with positive HBsAg, HBeAg and HBVDNA over six months, and all patients had a family history of chronic Hepatitis B. They were followed between...
Hepatitis B Virus Precore and Core Promotor Mutations in Children with Chronic Hepatitis B Infection
Woo Yeong Chung, Jin Kuk Kim, Yeong Hoon Kim, Yeong Hong Park, Chul Ho Kim
Clin Exp Pediatr. 1999;42(10):1392-1402.   Published online October 15, 1999
Purpose : The aims of this study were to investigate the frequencies and role of hepatitis B virus(HBV) precore and core promotor mutations in children with chronic hepatitis B infection. Methods : Sera from 31 children with chronic HBV infection were analyzed by direct sequencing of polymerase chain reaction amplification of HBV DNA. Results : Twenty-nine adr type were analyzed. The mutations...
The Therapeutic Effect of Interferon-alpha Treatment in Children with Chronic Hepatitis B
Il Sang Jeong, Ki Sup Chung
Clin Exp Pediatr. 1997;40(7):955-964.   Published online July 15, 1997
Purpose : The prevalance rate of chronic hepatitis B viral infection in children is high in our contry. We performed a prospective study to evaluate the effectiveness of and the factors predictive of response to interferon-alpha therapy in children with chronic hepatitis B. Methods : Thirty-two children with chronic hepatitis B werew admitted to the Department of Pediatrics, Yonsei University College of Medicine from...
Clinical and Histologic Changes in Children with Chronic Hepatitis B Virus Infection after Alpha Interferon Therapy
Kyung Mo Kim, Soo Jong Hong, Young Seo Park, Hyung Nam Moon, Chang Yee Hong, Joo Ryoung Huh
Clin Exp Pediatr. 1995;38(9):1232-1241.   Published online September 15, 1995
Purpose : Several trials in children for chronic hepatitis B have shown the efficacy of alpha interferon in eliminating hepatitis B virus replication, accompanied by an improvement in the liver cell damage. But reports about the alpha interferon therapy are rare in Korean children and there is no report about histologic changes even with adult. So we tried to...
A Clinical Study on Chronic Hepatitis b in the Children
Bon Su Koo, Han Sang Joo, Yung Tak Lim, Hee Ju Park
Clin Exp Pediatr. 1994;37(6):767-775.   Published online June 15, 1994
The author observed clinical study and response of -interferon treatment of 43 cases of chronic hepatitis who were admitted to Department of Pediatrics Pusan National University College of Medicine during the period of 4 year 6 months from Jenuary, 1988 to Jun, 1992. The results were as follows: 1) Of 43 patients with chronic hepatitis CPH was 17 cases (39.5%) and CAH...
Chronic Hepatitis B in Children.
Don Gyu Yang, Jong Kyun Lee, Pyung Kil Kim, Chang Ho Hong, Chul Lee
Clin Exp Pediatr. 1987;30(10):1115-1123.   Published online October 31, 1987
We reviewed 19 cases of chronic hepatitis B confirmed by liver biopsy during the 3 years and 5months from March 1983 to July 1986 at Young Dong Severance Hospital. The following results were obtained: 1) There were 16 boys and 3 girls with ages ranging from 7 months to 14 years old (mean+S.D.; 6.5 ±0.9 years). 2) There were 2 cases (10.5%) of chronic persistent...