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Original Article

The effects of adriamycin on twitch force and membrane potential in an isolated Guinea-pig papillary muscle.

Chan Uhng Joo, Pyung Han Hwang, Jung Soo Kim, Hee Cheol Yu, Soo Wan Chae

Clin Exp Pediatr. 1991;34(5):677-681. Published online May 31, 1991

The antiumor antibiotic adriamycin is presently considered to be a very effctive and useful chemotherapeutic agent in the treatment of many human tumors. Cardiotoxicity of adriamycin limits its clinical use. A number of hypotheses have been proposed to explain the mechanism of cardiotox- icity with adriamycin, but none has yet been demonstrated. The effects of adriamycin on twitch force and membrane potential in an...

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