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Original Article

Effect of CpG Oligodeoxynucleotides on Airways of Mice with Established Airways Inflammation

Hei-Won Hwang, Su-Jin Kim, Won-Duk Kim, Sung-Min Cho, Dong-Suk Lee, Sung-Min Choi

Clin Exp Pediatr. 2002;45(7):875-883. Published online July 15, 2002

Purpose : Airways eosinophilia and increased IgE, characteristic features of asthma, result from a predominant Th2 response. In this study, we investigated the effect of CpG oligodeoxynucleotides (ODNs) on the inhibition of airways eosinophilia in mice with established airway inflammation. We also investigated the immunological mechanisms involved. Methods : Groups of BALB/c mice were sensitized intradermally with ovalbumin(OVA). At week 10,...

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