Clinical and Experimental Pediatrics

Original Article

Gastroenterology

Dual-strain probiotics Bifidobacterium bifidum and Lactobacillus acidophilus reverse gut dysbiosis in preterm neonates: a randomized controlled trial

Setthawut Sittiwong, Pornthep Tanpowpong, Pisut Pongchaikul, Pracha Nuntnarumit

Clin Exp Pediatr. 2025;68(10):763-771. Published online August 6, 2025

Question: Can probiotics BB/LA reverse gut dysbiosis in preterm neonates?
Finding: BB/LA supplementation induced more diverse beta diversity and increased relative abundances of Bifidobacterium, Lactobacillus and decreased relative abundance Clostridium.
Meaning: Early BB/LA supplementation could reverse gut dysbiosis in preterm neonates.

DOI: https://doi.org/10.3345/cep.2025.00374

Review Article

Nutrition

Association of gut microbiota with obesity in children and adolescents

Ky Young Cho

Clin Exp Pediatr. 2023;66(4):148-154. Published online November 16, 2022

Web of Science 21 Crossref 24

The gut microbiota is an emerging factor in the development of pediatric obesity, which is affected by renowned risk factors such as diet, lifestyle, and socioeconomic status. This review aimed to describe the association between the gut microbiota and childhood obesity.

DOI: https://doi.org/10.3345/cep.2021.01837

Gastroenterology

Factors influencing development of the infant microbiota: from prenatal period to early infancy

Sujin Jeong

Clin Exp Pediatr. 2022;65(9):439-447. Published online December 23, 2021

Web of Science 35 Crossref 41

∙ Microbial colonization primarily occurs after birth but there may be some colonization in utero, although this remains highly controversial.
∙ Maternal factors during pregnancy affect the infant microbiota: diet, weight, gestational weight gain, and antibiotic usage.
∙ Microbes are passed from mother-to-infant during and after birth. Delivery mode, breastfeeding, early life antibiotic, and proton pump inhibitor treatment have the largest effects on microbial composition in early life.
∙ The early life gut microbiome plays an important role in the development of the immune system and metabolism.

DOI: https://doi.org/10.3345/cep.2021.00955

Cited By 31	Neurodevelopmental outcomes of preterm infants
Cited By 29	Long COVID in children and adolescents: prevalence, clinical manifestations, and management strategies
Cited By 27	Gut microbiota affects brain development and behavior
Cited By 24	Association of gut microbiota with obesity in children and adolescents
Cited By 24	Prevalence of anxiety, depression, and stress among parents of neonates admitted to neonatal intensive care unit: a systematic review and meta-analysis

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