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Original Article

Excess of leptin inhibits hypothalamic KiSS-1 expression in pubertal mice

Sung Yeon Ahn, Sei Won Yang, Hee Jae Lee, Jong Seon Byun, Ji Yeon Om, Choong Ho Shin

Clin Exp Pediatr. 2012;55(9):337-343. Published online September 14, 2012

Crossref 8

Purpose

Leptin has been considered a link between metabolic state and reproductive activity. Defective reproductive function can occur in leptin-deficient and leptin-excessive conditions. The aim of this study was to examine the effects of centrally injected leptin on the hypothalamic KiSS-1 system in relation to gonadotropin-releasing hormone (GnRH) action in the initial stage of puberty.

Methods

Leptin (1 µg) was injected directly into...

DOI: https://doi.org/10.3345/kjp.2012.55.9.337

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