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Review Article

Neonatology (Perinatology)

Surfactant preparations for preterm infants with respiratory distress syndrome: past, present, and future

Ga Won Jeon

Clin Exp Pediatr. 2019;62(5):155-161. Published online February 8, 2019

Crossref 34

Following the first successful trial of surfactant replacement therapy for preterm infants with respiratory distress syndrome (RDS) by Fujiwara in 1980, several animal-derived natural surfactants and synthetic surfactants have been developed. Synthetic surfactants were designed to overcome limitations of natural surfactants such as cost, immune reactions, and infections elicited by animal proteins contained in natural surfactants. However, first-generation synthetic surfactants...

DOI: https://doi.org/10.3345/kjp.2018.07185

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