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Review Article

Recent advances in the diagnosis and management of childhood acute promyelocytic leukemia

Eun Sun Yoo

Clin Exp Pediatr. 2011;54(3):95-105. Published online March 31, 2011

Since the successful introduction of all-trans-retinoic acid (ATRA) and its combination with anthracycline-containing chemotherapy, the prognosis for acute promyelocytic leukemia (APL) has markedly improved. With ATRA and anthracycline-based-chemotherapy, the complete remission rate is greater than 90%, and the long-term survival rate is 70-89%. Moreover, arsenic trioxide (ATO), which was introduced for APL treatment in 1994, resulted in excellent remission rates...

DOI: https://doi.org/10.3345/kjp.2011.54.3.95

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