Clinical and Experimental Pediatrics

Review Article

Nephrology (Genitourinary)

Effects of diethylene glycol contamination of pharmaceutical products on unexplained acute kidney injury in children: a systematic review

Sani Rachman Soleman, Muhammad Luthfi Adnan, Hilmi Ardian Sudiarto, Satria Bintang Mahathma, Alya Ayu Tazkia, Hana Afifah Firdaus, Alfreda Amelia Khotijah, Miranti Dewi Pramaningtyas, Emi Azmi Choironi

Clin Exp Pediatr. 2024;67(8):395-402. Published online January 4, 2024

A recent unexplained acute kidney injury (AKI) outbreak due to pharmaceutical product contamination with diethylene glycol (DEG) raises public attention. Our study revealed that DEG-contaminated paracetamol causes unexplained AKI in children. However, paracetamol is not the only contaminated drug. Other drugs, such as cough expectorants, antihistamines, and sedatives, can also be affected. Other chemicals, such as ethylene glycol and propylene glycol, can also contribute to poisonings.

DOI: https://doi.org/10.3345/cep.2023.01039

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