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Original Article

Nephrology (Genitourinary)

Impaired angiogenesis in the enalapril-treated neonatal rat kidney

Hyung Eun Yim, Kee Hwan Yoo, Eun Soo Bae, Young Sook Hong, Joo Won Lee

Clin Exp Pediatr. 2016;59(1):8-15. Published online January 22, 2016

Crossref 6

Purpose

Nephrogenesis is normally accompanied by a tightly regulated and efficient vascularization. We investigated the effect of angiotensin II inhibition on angiogenesis in the developing rat kidney.

Methods

Newborn rat pups were treated with enalapril (30 mg/kg/day) or vehicle (control) for 7 days after birth. Renal histological changes were checked using Hematoxylin & Eosin staining. We also investigated the intrarenal expression of vascular...

DOI: https://doi.org/10.3345/kjp.2016.59.1.8

Clinical Lecture

Pathophysiology of Persistent Pulmonary Hypertension of the Newborn

Yong Hoon Jun

Clin Exp Pediatr. 2004;47(7):707-715. Published online July 15, 2004

Persistent pulmonary hypertension of the newborn(PPHN) is a disorder characterized by persistence of the pattern of fetal circulation after birth due to a sustained elevation of pulmonary vascular resistance. The two primary events in the pathophysiology of neonatal pulmonary hypertension are hypoxic pulmonary vasoconstriction(HPV) and hypoxic pulmonary vascular remodeling(HPR). Chronic hypoxemia may cause increased muscularity of the pulmonary arteries and...

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