Clinical and Experimental Pediatrics

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Original Article

Serum Level of G-CSF and GM-CSF and CFU-GM Response to Hematopoietic Growth Factors in a Patient with Cyclic Neutropenia

Youn-Kyung Lee, Seok-Hun Kim, Kwang-Woo Kim, Soon Lee, Heung-Sik Kim, Dong-Seok Chun, Kun-Soo Lee

Clin Exp Pediatr. 2001;44(10):1168-1175. Published online October 15, 2001

Purpose : Serum levels of G-CSF and GM-CSF were measured and CFU-GM assay using G- CSF, GM-CSF and SCF was conducted to evaluate the influence of hematopoietic growth factor on the precursor cells of cyclic neutropenia. Methods : A 7-year-old male with cyclic neutropenia was studied. Marrow mononuclear cells were isolated at neutrophil nadir and recovery and cultured in methylcellulose media...

Case Report

A Case of Cyclic Neutropenia

Yoon Hwa Cha, Hye Sun Lee, Young Min Ahn, Myoung Sook Koo

Clin Exp Pediatr. 1993;36(7):1009-1015. Published online July 15, 1993

Cyclic Neutropenia is a benign, unusual hematologic disorder characterized by regularly recurring episodes of severe neutropenia occurring approximately every 21 days. Beside neutrophils, monocytes, lymphocytes, platelets and reticulocytes all cycle with strict periodicity suggest that this disease should be viewed as cyclic hematopoiesis, not merely as cyclic neutropenia. During neutropenic periods, patients regularly experience aphthous stomatitis, fever, malaise, cervical lymphadenitis, cutaneous...

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