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Original Article
Development of a Screening Kit for Early Diagnosis and Prevention of Wilson`s Disease
Sihoun Hahn, Soo-Young Lee, Young-Ju Jang, Soon-Nam Kim, Ha-Cheol Shin, Sun-Young Park, Joo-Hyoung Kang, Eun-Sun You
Clin Exp Pediatr. 2001;44(12):1374-1380.   Published online December 15, 2001
Purpose : Wilson`s disease is an autosomal recessive disorder characterized by copper accumulation in the liver, brain, and other organs due to defected copper metabolism. The incidence of Wilson`s disease is approximately one in 30,000 population in the world, more common than phenylketonuria in Korea. The early diagnosis or presymptomatic diagnosis of Wilson`s disease is critical in order for them...
Antibody Levels and Opsonophagocytic Function to S. pneumoniae 19F Capsular Polysaccharide
Kyung Hyo Kim, Ju Young Seoh, Moon Kook Park
Clin Exp Pediatr. 2001;44(4):405-412.   Published online April 15, 2001
Purpose : The increasing prominence of pneumococcal infections and of antimicrobial resistance has emphasized the need for a effective vaccine to reduce the risk of pneumococcal disease in childhood. To study the antibody response of pneumococcal vaccine, we compared the concentration and opsonophagocytic capacity of antibodies to the capsular polysaccharide of S. pneumoniae serotype 19F in sera from healthy adults...
Enzyme Amplification, A Method Applied to Provide An ELISA for Studying Anti-Hib-Ps Antibodies in Children
Kyung Hyo Kim, Moon H. Nahm
Clin Exp Pediatr. 1997;40(2):173-180.   Published online February 15, 1997
Purpose : Enzyme immunoassay (EIA) is now a widely used technique. We have described the application of enzyme amplification (sensitive ELISA) in the field of immunoassays of pediatric population. There are two issues with the sensitive ELISA. First is that one can minimize the serum volume, an important concern for pediatricians. The second is the problem of background signal. We demonstrate that it...
Trend of Maternal Measles Antibody in Korean Infants before 10 Months of Age
Phil-Soo Oh, Sung Hee Oh
Clin Exp Pediatr. 1995;38(5):619-624.   Published online May 15, 1995
Purpose : The measles epidemic occurrence has not well been controlled in Korea. Vaccin- ation schedule for measles in Korea has been modified in several occasions with insufficient da ta base. The most recent recommendation is to immunize at 9 months of age with measles va-ccine(at 6 months of age during epidemics) and reimmunize at 15 months of age with...
House Dust Mites Sensitivity in Korean Atopic children; Correlation between Skin Reaction and Relative Concentration of Specific IgE by ELISA
Ji Hong Kim, Soo Young Lee, Byeung Ju Jeung, Kye Earn Kim, Dong Soo Kim, Ki Young Lee
Clin Exp Pediatr. 1994;37(12):1701-1708.   Published online December 15, 1994
House dust mites, Dermatophagoides farinae and Dermatophagoides pteronyssius, have been identified as the main sources of house dust allergen and are considersed the most important causative allergen in the etiology of allergic respiaratory disease and allergic rhinitis. To evaluate the incidence of positive skin reactivity to house dust mites and relationship between total serum IgE levels and specific IgE antibody to...
Asymptomatic human rotavirus infections during infancy and preschool period.
Hye Lim Jung, Byoung Hoon Yoo, Tae Sub Shim
Clin Exp Pediatr. 1989;32(11):1482-1488.   Published online November 30, 1989
Asymptomatic human rotavirus (HRV) infection rate was studied by comparing the rate of HRV excretion in diarrhea cases with that in nondiarhea group of children under preschool age. HRV antigen in stool was detected by enzyme-linked immunosorbent assay (ELISA) from children under 6 years of age who were admitted to Pediatric Department of Chung-Ang University Medical Center from November 1988 to mid-April 1989. 1) HRV antigen...
Current Immune Status of Children and Pregnant Women in Korea(I).
Eun Jung Kim, Ju Kwan Park, Chang Hwi Kim, Sang Jhoo Lee
Clin Exp Pediatr. 1989;32(5):620-629.   Published online May 31, 1989
This study was conducted to find out rubella immune status as basic data for devising surveillance plan to prevent rubella epidemic and congenital rubella syndrome in Korea. Rubella ELISA antibody was tested to the study group of 253 cord blood. 352 children and 486 pregnant women. who visited Soonchunyhang University Hospital from Feb., 1987 to Oct.. 1987 The provisional results obstanined from the study...
Clinical Observation of Human Rota Virus(HRV) Gastroenteritis.
Kee Don Hong, Gil Hyun Kim, Jae Ock Park, Sang Jhoo Lee
Clin Exp Pediatr. 1988;31(6):700-706.   Published online June 30, 1988
This study was done with the 96 patients with watery diarrhea from Oct. to Nov. 1986. ELISA study was done to detect Human Rota Virus antigen for all patients. Clinical and laboratory comparision were made between HRV antigen positive group and HRV antigen negative group. The results were as follows: 1) HRV antigen was detected in 62 patients (64.6%) among 96 patients of diarrhea or...
Clinical, epidemiological, and serological observation on human rotavirus gastroenteritis in infants and children.
Chin Moo Kang
Clin Exp Pediatr. 1985;28(2):140-146.   Published online February 28, 1985
The author studied 115 infants with watery diarrhea, admitted to the Pediatric Department of Dorg San Medical Center during the period of 9 months from October 1982 through June 1983 and dsveloped an Enzyme lirked immunosorbent assay to detect human rota virus antigen for all patients and clinical, epidemiologic, and laboratory studies were done. The results were as follows: 1)76...