Clinical and Experimental Pediatrics

Review Article

Eosinophil-derived neurotoxin levels can predict allergic disease development and atopic march in children

Zak Callaway, Chang-Keun Kim

In some children, atopic manifestations begin with atopic dermatitis and progress to allergic asthma and allergic rhinitis; of them, a small subset experience food allergies as well. This progression shares genetic and environmental predisposing factors and immunological features, such as allergen-specific T helper type 2 responses, that manifest as specific immunoglobulin E production and eosinophil activation. Eosinophil-derived neurotoxin (EDN), which...

DOI: https://doi.org/10.3345/cep.2024.01382 [Accepted]

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Allergy

Montelukast use over the past 20 years: monitoring of its effects and safety issues

Yong Ju Lee, Chang-Keun Kim

Clin Exp Pediatr. 2020;63(10):376-381. Published online February 5, 2020

Web of Science 20 Crossref 17

Although the efficacy of montelukast is inferior to that of ICS, both physicians and parents prefer montelukast to ICSs.
EDN may be a useful biomarker for the treatment and monitoring of preschool children with asthma.
The US FDA requires boxed warning about serious neuropsychiatric events of montelukast, therefore, physicians should consider the benefits and risks of montelukast before prescribing it.

DOI: https://doi.org/10.3345/cep.2019.00325

Eosinophil-derived neurotoxin: a novel biomarker for diagnosis and monitoring of asthma

Chang-Keun Kim

Clin Exp Pediatr. 2013;56(1):8-12. Published online January 29, 2013

Crossref 39

Asthma is associated with increased levels of eosinophils in tissues, body fluids, and bone marrow. Elevated levels of eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP) have been noted in asthma patients. Higher levels of EDN and ECP are also associated with exacerbated asthmatic conditions. Thus, EDN, along with ECP, may aid the diagnosis and monitoring of asthma. Several groups...

DOI: https://doi.org/10.3345/kjp.2013.56.1.8

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