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Original Article

Glutathione S-transferase polymorphism of neonatal hyperbilirubinemia in Korean neonates

Chang Seok Kang, Seung Su Hong, Ji Sook Kim, Eun Ryoung Kim

Clin Exp Pediatr. 2008;51(3):262-266. Published online March 15, 2008

Purpose : Glutathione S-transferase (GST) is a polymorphic supergene family of detoxification enzymes that are involved in the metabolism of numerous diseases. Several allelic variants of GSTs show impaired enzyme activity and are suspected to increase the susceptibility to diseases. Bilirubin is bound efficiently by GST members. The most commonly expressed gene in the liver is GSTM1, and GSTT1 is...

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