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Original Article

Effect of Perinatal Asphyxia and Gentamicin on Urinary β2-microglobulin Concentration and Renal Function in Fullterm Neonates

Hoo Jae Hann, Seung Joo Lee

Clin Exp Pediatr. 1994;37(7):976-985. Published online July 15, 1994

Perinatal asphyxia can cause ischemic injury to immature kidney of neonates. Proximal renal tubule is the most sensitive area, showing various manifestations ranging from mild reversible injury to irreversible tubular necrosis. Aminoglycosides can be nephrotoxic in therapeutic range in immature or damaged kidney. These are the very important factors to be taken into corsideration on fluid therapy and nephrotoxic drugs...

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