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Original Article

A Study on the Serum Level of Phenytoin after Intravenous Administration of Loading Dose

In Joon Seol, Young Iee Yu

Clin Exp Pediatr. 1997;40(10):1435-1442. Published online October 15, 1997

Purpose : Phenytoin is effectively and widely used drug for the treatment of status epilepticus and patient with ongoing seizure by intravenous infusion. It is generally recommended to maintain serum concentration above 10μg/ml for the sustained effective anticonvulsant effect. This study was designed to know the optimal time to begin oral maintenance therapy after initial intravenous infusion. Methods : Total 17 patients with status epilepticus...

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