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Original Article
Neonatology (Perinatology)
Mortality of very low birth weight infants by neonatal intensive care unit workload and regional group status
Sung-Hoon Chung, Chae Young Kim, Yong-Sung Choi, Myung Hee Lee, Jae Woo Lim, Byong Sop Lee, Ki-Soo Kim; the Korean Neonatal Network
Clin Exp Pediatr. 2024;67(11):619-627.   Published online September 12, 2024
Question: How do structural and staffing characteristics of neonatal intensive care units (NICUs) influence the mortality rates of very low birth weight infants (VLBWIs)?
Findings: NICUs with higher staffing levels, particularly with more neonatologists, and those offering advanced care levels were associated with lower mortality rates. Additionally, regional disparities were observed, with some areas demon-strating significantly higher survival rates.
Meaning: Adequate staffing and equitable regional distribution of medical resources are crucial for improving survival outcomes in VLBWIs. Efforts to enhance NICU staffing and address regional healthcare disparities are essential for optimizing care quality and reducing mortality in this vulnerable population.
Neonatal sepsis-causing bacterial pathogens and outcome of trends of their antimicrobial susceptibility a 20-year period at a neonatal intensive care unit
Woo Sun Song, Hye Won Park, Moon Youn Oh, Jae Young Jo, Chae Young Kim, Jung Ju Lee, Euiseok Jung, Byong Sop Lee, Ki-Soo Kim, Ellen Ai-Rhan Kim
Clin Exp Pediatr. 2022;65(7):350-357.   Published online December 9, 2021
Question: What is prevalence of bacterial pathogens causing sepsis and their antimicrobial susceptibility over 20 years?
Finding: Coagulase-negative remains most common causative organism. The most common gram-negative organism was Klebsiella pneumonia. The susceptibility of staphylococcus aureus and K. pneumonia showed increased susceptability to oxacillin, cefotaxime and amikacin, gentamicin, respectively.
Meaning: Answers to the question asked is important in choosing antimicrobials and to monitor emergence of multidrug-resistant organisms.
Developmental and Behavioral Medicine
Validity of the Korean Developmental Screening Test for very-low-birth-weight infants
Chae Young Kim, Euiseok Jung, Byong Sop Lee, Ki-Soo Kim, Ellen Ai-Rhan Kim
Clin Exp Pediatr. 2019;62(5):187-192.   Published online March 20, 2019

Purpose: The importance of the neurodevelopmental outcomes of very-low-birth-weight (VLBW) infants has been emphasized as their mortality rate has markedly improved. This study aimed to assess the validity of the Korean Developmental Screening Test (K-DST), a developmental screening tool approved by the Korean Society of Pediatrics, for the timely diagnosis of neurodevelopmental delay in VLBW infants. Methods: Subjects included VLBW infants...
Case Report
Neonatology (Perinatology)
Case of mucinous adenocarcinoma of the lung associated with congenital pulmonary airway malformation in a neonate
Juneyoug Koh, Euiseok Jung, Se Jin Jang, Dong Kwan Kim, Byong Sop Lee, Ki-Soo Kim, Ellen Ai-Rhan Kim
Clin Exp Pediatr. 2018;61(1):30-34.   Published online January 22, 2018

Congenital pulmonary airway malformation (CPAM), previously known as congenital cystic adenomatoid malformation, is a rare developmental lung abnormality associated with rhabdomyosarcoma, pleuropulmonary blastoma, and mucinous adenocarcinoma of the lung. We report an unusual case of a 10-day-old male newborn with a left lower lobe pulmonary cyst who underwent lobectomy, which revealed type II CPAM complicated by multifocal mucinous adenocarcinoma. KRAS...

Review Article
Trends in survival rate for very low birth weight infants and extremely low birth weight infants in Korea, 1967-2007
Ki-Soo Kim, Chung-Woo Bae
Clin Exp Pediatr. 2008;51(3):237-242.   Published online March 15, 2008
To investigate the trends in the survival rate (SR) for very low birth weight infants (VLBW) and extremely low birth weight infants (ELBWI) in Korea, a total of 43 articles pertaining to SR were analyzed, covering the years from 1967 to 2007. The changes in SR were compared using 5 year periods. The SR for VLBWI has increased remarkably, from...
Original Article
Immune responses of hepatitis B vaccination among very low birth weight infant
Young-Deuk Kim, Myung-Ki Han, Ai-Rhan E. Kim, Ki-Soo Kim, Soo-Young Pi
Clin Exp Pediatr. 2006;49(8):857-863.   Published online August 15, 2006
Purpose : To evaluate the immunogenicity of hepatitis B vaccine among very low birth weight infants(VLBWI) who were vaccinated at 0, 1, 6 months of chronological age and to determine the factors associated with antibody formations. Methods : A total of 243 VLBWI admitted to Seoul and Gangneung Asan Medical Center neonatal intensive care units from 1997 to 2004 were...
Molecular-epidemiologic study on outbreak of colonization by extended spectrum β-lactamase producing Klebsiella pneumoniae in neonatal intensive care unit
Nu-Lee Jun, Mi-Na Kim, Jae-Sim Jeong, Yang-Soo Kim, Ellen Ai-Rhan Kim, Ki-Soo Kim, Soo-Young Pi
Clin Exp Pediatr. 2006;49(2):150-156.   Published online February 15, 2006
Purpose : The aims of this study included assessment of molecular-epidemiologic features during an outbreak of colonization of extended spectrum β-lactamase producing Klebsiella pneumoniae(ESBL- KPN) and re-evaluation of their colonized status one year later. Methods : Rectal swab cultures for ESBL-KPN from all hospitalized infants and newly admitted infants were obtained during the outbreak of colonization from July to December,...
Intrauterine Intraventricular Hemorrhage in Premature Infants
Hyun-Seung Jin, Kyeng-Ah Park, Hyun-Woo Goo, Jong-Hyun Yoon, Ellen Ai-Rhan Kim, Ki-Soo Kim, Soo-Young Pi
Clin Exp Pediatr. 2005;48(1):27-33.   Published online January 15, 2005
Purpose : To determine incidence, characteristics and risk factors associated with intrauterine intraventricular hemorrhage(IU-IVH) among premature infants. Methods : The medical records of infants with intraventricular hemorrhage(IVH) admitted to the neonatal intensive care unit of Asan Medical Center from January 1999 to June 2003 were reviewed retrospectively. Infants whose IVH with cystic change were detected within five days of life were...
Case Report
A Case of Pulmonary Artery Sling Misdiagnosed as Bronchial Asthma
Eun-Jung Cheon, Ki-Soo Kim, Jae-Woo Lim, Kyung-Ok Koh
Clin Exp Pediatr. 2004;47(10):1110-1113.   Published online October 15, 2004
Anomalous left pulmonary artery(pulmonary artery sling) is a congenital anomaly in which the vascular structure arises either from the posterior surface of the right pulmonary artery, or from the main pulmonary artery and courses to the left lung between the posterior surface of the trachea and the anterior surface of the esophagus. It may compress on the tracheobronchial tree causing...
Original Article
Clinical Characteristics and Epidemiologic Study of Infection Due to Extended Spectrum β-Lactamase Producing Organism in a Neonatal Intensive Care Unit
Nu-Lee Jun, Jae-Woo Im, Hyun-Kyung Park, Mi-Na Kim, Ellen Ai-Rhan Kim, Ki-Soo Kim, Soo-Young Pi
Clin Exp Pediatr. 2004;47(4):373-379.   Published online April 15, 2004
Purpose : The extended-spectrum β-lactamase(ESBL) producing organism have emerged to be an important pathogen in neonatal intensive care unit(NICU). This study was conducted to investigate incidence, characteristics and risk factors associated with ESBL organism among newborns in NICU. Methods : The subjects included 98 newborns admitted to NICU at Asan Medical Center between September 1998 to July 2002, from whom...
Case Report
A Case of Netherton's Syndrome in a Newborn
Eun-Hee Lee, Ellen Ai-Rhan Kim, Ki-Soo Kim, Beom-Jin Cho, Jai-Kyoung Koh, Soo-Young Pi
Clin Exp Pediatr. 2003;46(4):389-392.   Published online April 15, 2003
Netherton's syndrome is an unusual disorder which consists of triad of ichtyosiform dermatosis, multiple defects of hair shaft and an atopic diathesis. The finding of bamboo hair is pathognomic in Netherton's syndrome and the ichthyosiform dermatosis may consist of either ichtyosis linearis circumflexa or congenital ichthyosiform erythroderma. Often, variability in the clinical features leads to a delay in diagnosis in...
Original Article
Maternal and Neonatal Outcome of Twin Pregnancies after in vitro Fertilization and Embryo Transfer
Kyung-Ah Kim, Uoo-Gyung Min, Jae-Woo Lim, Nu-Lee Jun, Hye-Sung Won, Chung-Hoon Kim, Ellen Ai-Rhan Kim, Pil-Ryang Lee, In-Sik Lee, Ki-Soo Kim, Ahm Kim, Soo-Young Pi
Clin Exp Pediatr. 2003;46(3):224-229.   Published online March 15, 2003
Purpose : To examine various neonatal outcomes and perinatal factors resulting from assisted reproduction compared to that of spontaneous conception. Methods : This is a retrospective study. The control cases were all twins of spontaneous conception born between periods from January 1995 to June 2000. The study cases were identified from twins conceived by assisted reproduction in the same time peried....
Neuro-developmental Assessment of Patients with Transposition of the Great Arteries by Localized 1H-Magnetic Resonance Spectroscopy
Ki-Soo Kim, Jee-Yeon Min, So Young Yoon, Young Hwue Kim, Jae Kon Ko, In Sook Park, Ki-Soo Kim, Dong Man Seo, Sang-Tae Kim, Jung Hee Lee, In Kyung Sung
Clin Exp Pediatr. 2001;44(5):533-544.   Published online May 15, 2001
Purpose : The purpose of this study was to evaluate the hemodynamic effect of transposition of the great arteries(TGA) on neuro-development by measuring the cerebral metabolites before and 1 year after open heart surgery(OHS) by localized in vivo 1H-magnetic resonance spectroscopy(1H- MRS) along with Bayley scales of infants development II(BSID II). Methods : Full-term newborns(N=13) with TGA and intact ventricular septum...
Case Report
A Case of Korean Patient with Nonketotic Hyperglycinemia; Diagnosed Based on CSF Amino Acid Analysis and Magnetic Resonance Spectroscopy
Kie-Young Park, Ai-Rhan Kim, Ki-Soo Kim, Soo-Young Pi, Tae-Sung Ko, Jung-Hee Lee, Han-Wook Yoo
Clin Exp Pediatr. 2000;43(7):993-999.   Published online July 15, 2000
Nonketotic hyperglycinemia is an extremely rare congenital metabolic disorder, which is caused by the lack of a glycine cleavage system. The onset of hyperglycinemic symptom is during the neonatal or early infant period. Progressing grave neuromotor dysfunction is one of the main symptoms. They include myoclonic seizure, hiccup, apnea, decreased deep tendon reflex, lethargy and coma. The prognosis is mostly very poor. Furthermore, there...
Original Article
Antenatal Thyrotropin-Releasing Hormone to Prevent Respiratory Distress Syndrome in Preterm
Ai-Rhan Kim, Sung-Jong Park, Hye-Sun Yoon, Ki-Soo Kim, Hye-Sung Won, In-Sik Lee, Ahm Kim, Soo-Young Pi
Clin Exp Pediatr. 1999;42(7):911-920.   Published online July 15, 1999
Purpose : The purpose of this study was to assess the efficacy of antenatal thyrotropin-releasing hormone(TRH) given to mothers at risk for preterm delivery and assess various neonatal outcomes in infants born to these mothers. Methods : Sixty-one mothers(TRH＋Dexamethasone(D):30, D:31) with preterm labor at 26-34 weeks of gestational age were randomized into a study group which received 400μg of TRH at...
Delayed Cerebral Energy Failure After Acute Hypoxia-Ischemia in Neworn Piglet Under 48hours of Continuous Monitoring Using Near-Infrared Spectroscopy
Yun Sil Chang, Won Soon Park, Munhyang Lee, Ki-Soo Kim, Jung-Hwan Choi, Son Moon Shin
Clin Exp Pediatr. 1998;41(9):1198-1210.   Published online September 15, 1998
Purpose : To test the hemodynamic and biochemical sequences of secondary cerebral energy failure after acute reversed hypoxic ischemic brain insult(HI) can be reproduced in newborn piglets. Methods : Fifteen anesthetized, ventilated newborn piglet(<3 day) were studied. Eight(HI) were induced transient HI by breathing 8% oxygen and complete occlusion of bilateral common carotid arteries for 30 minutes followed by reoxygenation...