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Original Article
Clinical characteristics and risk factors for staphylococcal infections in neonatal intensive care unit
Min Kook Chung, Jeong Ho Choi, Jin Keun Chang, Sung Hoon Chung, Chong Woo Bae, Sung Ho Cha
Clin Exp Pediatr. 2006;49(12):1287-1295.   Published online December 15, 2006
Purpose : The importance of staphylococcal infections in NICU has been emphasized in terms of increased resistant strains and increased incidence of morbidity and mortality. In this study, we inrestignted the clinical characteristics and risk factors for staphylococcal infections, and looked into sensitivity trends of antibiotics in the era of a high rate of methicillin-resistant staphylococcus aureus (MRSA) in our...
Case Report
Intrathyroidal branchial cleft-like cyst in neonate
Joonwon Kang, Sangmin Oh, Jiyoung Sul, Choongsik Lee, Meayoung Chang
Clin Exp Pediatr. 2006;49(9):1005-1009.   Published online September 15, 2006
A rare case is described of an intrathyroidal branchial cleft-like cyst in neonate. The patient was a newborn girl with a mass in the left lateral neck. The ultrasonography and computed tomography revealed a cystic lesion in the left thyroid. The lesion was enucleated surgically from the thyroid. Histologically, the cyst was lined by squamous or columnar epithelium and contained...
Original Article
Diagnostic limitation and usefulness of 99mTc-DISIDA hepatobiliary scanning on neonatal cholestasis
Jung Mi Kim, Byung-Ho Choi, You Cheol Jang, Ki Won Oh, Min Hyun Cho, Kyung Hee Lee, Jin-Young Park, Heng Mi Kim
Clin Exp Pediatr. 2006;49(7):737-744.   Published online July 15, 2006
Purpose : To assess the usefulness of 99mTc-DISIDA scanning in the early evaluation of neonatal cholestasis and to verify the diagnostic value of this test in the differential diagnosis of biliary atresia. Methods : DISIDA scannings were performed and analyzed in 87 children(58 males and 29 females; age, 18-139 days, mean, 59.1 days) with neonatal cholestasis. Five groups according to the...
Neonatal hearing screening in a neonatal intensive care unit using distortion product otoacoustic emissions
Do Young Kim, Sung Shin Kim, Chang Hwi Kim, Shi Chan Kim
Clin Exp Pediatr. 2006;49(5):507-512.   Published online May 15, 2006
Purpose : Early detection and intervention of hearing impairment is believed to improve speech and language development and behavior of children. The aim of this preliminary study was to determine the prevalence of hearing impairments, and to identify the association of risk factors relating to refer response in high risk neonates who were screened using distortion product otoacoustic emissions (DPOAE). Methods...
Case Report
Congenital central I42hypoventilation syndrome combined with Hirschsprung disease diagnosed in the neonatal period
Jin Hyun Choi, Jin Hee Oh, Jong-Hyun Kim, Dae Kyun Koh, Seung-Chul Hong
Clin Exp Pediatr. 2006;49(4):446-450.   Published online April 15, 2006
Congenital central hypoventilation syndrome (CCHS) or Ondine's curse is a very rare sleep disorder that is the result of a congenital failure of the autonomic control of ventilation caused by insensitivity of the chemoreceptor to hypercapnea during sleep. Gastrointestinal motility disorders, particularly a congenital megacolon (Hirschsprung disease) is often combined with CCHS. This combination can be explained by a defect...
A Single Nucleotide Deletion resulting in Frameshift in Two Korean Neonates with Thyroxine-Binding Globulin Deficiency
Sang-Joon Park, Jin-Soon Suh, Min-Ho Jung, Hee-Jin Lee, Hee-Jin Lee, Won-Bae Lee, Byung-Churl Lee
Clin Exp Pediatr. 2005;48(11):1252-1255.   Published online November 15, 2005
Abnormalities in the levels of thyroxine-binding globulin (TBG) are not associated with clinical disease and they do not require treatment. Congenital TBG deficiency is inherited in an X-linked manner. To date, some complete and partial TBG variants and one polymorphism have been identified by analysis of the TBG gene. Two male neonates were referred to us because of their low...
Original Article
Clinical Features of Symptomatic Neonates with Ebstein's Anomaly
Hee Jin Cho, In Sil Lee, Jae Kon Ko
Clin Exp Pediatr. 2005;48(11):1212-1218.   Published online November 15, 2005
Purpose : Forward pulmonary blood flow may be absent in some neonates with Ebstein's anomaly by anatomical or functional pulmonary atresia in association with the elevated pulmonary vascular resistance, patent ductus arteriosus and tricuspid regurgitation. We reviewed the presentation and outcomes of symptomatic neonates with Ebstein's anomaly focusing on the pulmonary atresia. Methods : Clinical presentation and outcome of 15 symptomatic...
Clninical Features of Rotaviral Gastroenteritis in Neonates
Shin-I Park, Hae Oak Kwon, Jun Ho Lee, Su Jin Jung
Clin Exp Pediatr. 2005;48(10):1121-1125.   Published online October 15, 2005
Purpose : Rotavirus is the main cause of infantile diarrheal disease worldwide, especially in patients 3-24 months of age. Infants younger than 3 months of age are relatively protected by transplacental antibody. So the purpose of this study is to evaluate the clinical features and severity of neonatal rotaviral gastroenteritis less than 1 month of age. Methods : A retrospective chart...
Prevalence and Risk Factors of Vancomycin-Resistant Enterococci (VRE) Colonization in Neonates
Hwa Yun Lee, Gi Hwan Kim, Jin Su Choi, Sun Hee Kim, Young Youn Choi, Tai Ju Hwang
Clin Exp Pediatr. 2005;48(9):946-952.   Published online September 15, 2005
Purpose : Vancomycin-resistant enterococci(VRE) are now nosocomial pathogens in Korea. But little is known about the prevalence of stool colonization with VRE in neonates in Korea. So we studied the prevalence and risk factors of VRE colonization in the Neonatal Intensive Care Unit(NICU). Methods : From January 2000 to December 2004, the medical records of 294 neonates(127 cases of VRE group...
Case Report
A Case of Chylous Mesenteric Cyst in a Neonate
Hyun Taek Lim, Jung Hwa Lee, So Hee Lee, Jeong Eun Kim, Seong Jin Hong, Young Chil Choi, Sang Yun Kim
Clin Exp Pediatr. 2005;48(5):569-571.   Published online May 15, 2005
Mesenteric cysts are one of the least common intraabdominal lesions, which are very rare in neonates. Among mesenteric cysts, a chylous cyst is the rarest one of all. This entity can be found anywhere in the gastrointestinal tract from the duodenum to the rectum. Mesenteric cysts may be asymptomatic and found on routine examinations, or can present with symptoms such...
Original Article
Serum Albumin Concentrations and Clinical Disorders by Gestational Ages in Preterm Babies
Mia Lee, Soo Youn, Baek Keun Lim, Jong Soo Kim
Clin Exp Pediatr. 2005;48(2):148-153.   Published online February 15, 2005
Purpose : The aim of this study was to determine the reference ranges of serum albumin levels depending on the gestational ages of preterm infants. We also intended to compare the mean serum albumin levels between groups of preterm infants that did not develop clinical disorders later, and groups that did develop clinical disorders such as respiratory distress syndrome, intraventricular...
Case Report
A Case of Neonatal Lupus with Abnormal Liver Function Test and Skin Lesion
Ju-Young Chung, Myoung Jae Chey
Clin Exp Pediatr. 2005;48(1):85-87.   Published online January 15, 2005
Neonatal lupus(NL) is characterized by typical clinical features and the presence of maternal auto- antibodies. The principal serologic markers of NL are anti-Ro/SSA or anti-La/SSB maternal auto- antibodies, which are transferred across the placenta and can be detected for the first few months of the affected child. The major clinical manifestations are cardiac disease, notably congenital heart block, and cutaneous...
Original Article
The Clinical Study on the Neonate Delivered Under the Condition of the Maternal Smoking and Alcohol in Pregnancy
Sun Hui Kong, Soo Yeon Kim, Ho Jun Lee, Hak Sung Kim, Dong Woo Lee, Jae Yoon Kim
Clin Exp Pediatr. 2005;48(1):34-39.   Published online January 15, 2005
Purpose : Perinatal complications associated with maternal smoking and alcohol ingestion in pregnancy have been well documented. But until now there has been no clinical data on it collected in our country. In this paper, we tried to research the association between maternal smoking and alcohol ingestion in pregnancy and the physical indices of the neonate at delivery among unmaried...
Clinical Features of Septic Arthritis in Neonates
Min Jung Kwak, Su Eun Park
Clin Exp Pediatr. 2004;47(11):1161-1166.   Published online November 15, 2004
Purpose : Septic arthritis is uncommon in neonates, and the diagnosis of septic arthritis in newborns is difficult because of non-specific laboratory findings and paucity of signs and symptoms. When appropriate treatment is delayed, permanant sequelae are inevitable. We report a retrospective study of 22 neonates who were diagnosed with septic arthritis. Methods : We reviewed 22 patients, who were diagnosed...
Assessment of Cardiac Function in Neonates by Using Tissue Doppler Imaging
Hee Chul Yoon, Jae Hoon Choe, Sun Young Kim, In Kyu Lee, Myung Ho Oh
Clin Exp Pediatr. 2004;47(9):959-964.   Published online September 15, 2004
Purpose : Tissue Doppler imaging(TDI) is recently being used for assessement of regional ventricular function in adults. However, data in neonates have not been established yet. The aim of this study is to establish reference values of TDI velocities and to investigate the effect of other factors on TDI velocites in the neonatal population. Methods : Forty eight healthy neonates with...
A Comparison of Clinical Manifestations in Neonates and Infants Infected by Respiratory Syncytial Virus
In Suk Lim, Min Joo Shim, Byung Eui Kim, Ju Young Chung, Chang Keun Kim, Myoung Jae Chey, Sang Woo Kim, Soung Hee Kim, Tae Hee Han
Clin Exp Pediatr. 2004;47(9):949-952.   Published online September 15, 2004
Purpose : This study was performed to evaluate of clinical manifestations of neonatal respiratory syncytial virus(RSV) infection, and to evaluate of differences of clinical manifestations between the neonates and infants who were infected by RSV. Methods : We reviewed the medical record of 75 children who were younger than 12 months of age and infected by RSV. We classified then into...
The Change in Intestinal Lactobacillus Count among Healthy Neonates
Hyun Joo Lee, Hyun Ji Lee, Su Jin Cho, Jung Wan Seo, Seung Joo Lee, Eun Ae Park
Clin Exp Pediatr. 2004;47(8):833-838.   Published online August 15, 2004
Purpose : Enhancing overall health by preventive and therapeutic use of probiotics has shown great promise on inflammatory, infectious, neoplastic disorders, allergies, et al. To attain preliminary data for the use of probiotics, we have studied the change in intestinal flora, Lactobacillus count among healthy, full term neonates. Methods : Fresh stool samples were collected on the 2nd or 5th day...
Clinical Findings of Sepsis-Associated Cholestasis in the Neonates
Soo Jung Yoon, Chun Soo Kim, Sang Lak Lee
Clin Exp Pediatr. 2004;47(4):380-385.   Published online April 15, 2004
Purpose : Bacterial endotoxins or inflammatory cytokines are known to be important causes of cholestasis in patients with systemic infections such as sepsis. This study was undertaken to investigate the clinical features of cholestasis in newborn infants with sepsis. Methods : This study included 17 neonates with cholestasis diagnosed at the time of septicemia who had no previous history of cholestasis....
Case Report
A Case of Cutis Verticis Gyrata due to Cerebriform Intradermal Nevus in the Neonate
Hye Ryung Choi, Hyun Joo Lee, Eun Ae Park
Clin Exp Pediatr. 2004;47(2):223-226.   Published online February 15, 2004
Cutis verticis gyrata(CVG) is a morphologic syndrome of the scalp characterized by folds and furrows resembling the surface of brain. The primary form of cutis verticis gyrata is commonly associated with a neuropsychiatric condition and a secondary form occurs as a response of inflammatory or neoplastic process. The patient was a 1-day-old girl, who had a 15?1 cm sized, convoluted...
Original Article
Causative Organisms in Children with Bacterial Meningitis(1992-2002)
Hyun-Jung Kim, JI-Won Lee, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Seung-Hoon Hahn, Kyung-Tai Whang
Clin Exp Pediatr. 2003;46(11):1085-1088.   Published online November 15, 2003
Purpose : This study was performed to assess the difference of organisms causing bacterial meningitis according to time. Methods : We analyzed retrospectively 40 medical records of bacteriologically proven meningitis from 1992 to 2002. We divided them into two groups; neonate's group(14 cases), and children's group(26 cases). The results of the neonate's group were compared with those of previously reported articles...
The Difference between Clinical Manifestations and Feeding or Delivery Methods in Healthy Full-term Neonates and Those with Nosocomial Rotaviral Infection
So Young Lee, Hyun Ji Kim, Mi Young Kim, Won Duck Kim, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
Clin Exp Pediatr. 2003;46(5):454-458.   Published online May 15, 2003
Purpose : Rotavirus is the main cause of infantile diarrheal disease worldwide. The purpose of this study is to assess the difference between clinical manifestations and feeding or delivery methods in healthy full-term neonates and those with nosocomially-acquired rotaviral infection. Methods : The study was conducted on 348 babies who were delivered in Dongguk University Kyongju Hospital from Jan 1...
Case Report
A Case of Subcutaneous Fat Necrosis in Neonate with Meconium Aspiration Syndrome
Mi Ae Hong, Kyung Chang Oh, Seung In Ahn, Hye Jung Shin, Jin Keun Chang, Byung Doo Lee, Beyong Il Kim, Jung-Hwan Choi
Clin Exp Pediatr. 2002;45(11):1422-1425.   Published online November 15, 2002
Subcutaneous fat necrosis in neonates is a rare disease characterized by skin lesions, which may be single or multiple, poorly circumscribed and often tender erythematous nodules or plaques on cheeks, buttocks, back, arms, and thighs. These symptoms are usually self-limited; resolution occurs over a period of weeks to months. Subcutaneous fat necrosis affects full term and healthy- appearing infants who...
Original Article
Frequency of Platelet Transfusions and Outcome in Neonates with Thrombocytopenia
Suk-Hwan Lim, Jin-Hwa Kook, Chang-Yee Cho, Young-Youn Choi, Tai-Ju Hwang
Clin Exp Pediatr. 2002;45(8):961-966.   Published online August 15, 2002
Purpose : We compared the underlying or associated diseases according to the frequency of platelet transfusions in neonates with thrombocytopenia to know the factors predicting which patients will require multiple platelet transfusions. We also compared mortality. Methods : A retrospective study was performed in 72 neonates who received the platelet transfusions in neonatal intensive care unit(NICU) between August 1996 and July...
Study of Neonatal Cardiac Catheterization for Over the Last 10 Years
Jinyoung Song, Sungkyu Lee, Jaeyoung Lee, Sujin Kim, Wooseup Shim
Clin Exp Pediatr. 2002;45(5):615-621.   Published online May 15, 2002
Purpose : The neonatal cardiac catheterization and angiogram for transcatheter therapy are still essential methods in congenital heart disease, so we reviewed our experience with neonatal cardiac catheterization over 10 years at a single institution. Methods : A retrospective review of all 139 neonatal catheterizations from January 1991 to December 2000 at Sejong Heart Institution was performed. The purpose of the...
Availability of Capillary Blood Gas Analysis in Neonate
Jong Tae Jeong, Su Young Yun, Ran Lee, Jae Ho Hyun, Gyu Young Jung
Clin Exp Pediatr. 2002;45(4):449-453.   Published online April 15, 2002
Purpose : Arterial blood gas analysis is frequently performed in neonatal intensive care unit (NICU) to evaluate ventilation and the metabolic state of critically ill infants. In occasions when umbilical arterial catheterization is not available, frequent arterial puncture is mandatory. This requires some technical skill and may occasionally have side effects. So we studied the validity of capillary blood gas...
Case Report
Two Cases of Infantile Hemangioendothelioma of the Liver in Neonates
Soo Jin Han, Soo Shin Cho, Gwang Hoon Lee, Ho Joon Im, Seong Ho Kim, Gil Hyun Kim, Hak Soo Lee
Clin Exp Pediatr. 2001;44(12):1469-1474.   Published online December 15, 2001
Infantile hemangioendothelioma(IHE) of the liver is a rare benign vascular tumor that presents most commonly in infants before the age of 6 months. IHE presents as abdominal mass, cutaneous hemangiomas, unexplained jaundice, bleeding disorders, or congestive heart failure. Death often results from congestive heart failure despite appropriate treatment with digoxin and diuretics. IHE also is associated with Kasabach-Merritt syndrome, anemia,...
Original Article
Methemoglobinemia Associated with Diarrheal Disease before 2 Months of Ag
Ji Ah Jung, Jung Won Lee, Jeong Wan Seo
Clin Exp Pediatr. 2001;44(12):1387-1394.   Published online December 15, 2001
Purpose : Methemoglobinemia has been observed during a diarrheal illness among those who were not exposed to oxidizing agents in neonates and young infants. We performed the study to determine predisposing factors in this entity. Methods : The medical records of 24 patients were reviewed, who were admitted for diarrhea with methemoglobinemia to Ewha Womans University MokDong Hospital, from February 1994 to November 2000. The...
The Effect of Soothing Classic Music on the Behavior and Initial Weight Loss of Newborn Infants
Min Jung Cho, Son Moon Shin
Clin Exp Pediatr. 2001;44(12):1381-1386.   Published online December 15, 2001
Purpose : As there are some reports that music affects some physiological parameters and behavior of preterm infants, we have attempted to evaluate the effect of soothing classic music on the behavior and initial weight loss of full term infants. Methods : A clinical study was conducted on newborn infants born at Youngnam University Hospital from July to August, 1999. Forty normal full term...
Case Report
Three Cases of Acute Scrotal Disorders in the Neonate
Ja Yun Yun, Min Kyoung Kwon, Mi Ran Kim, Kon Hee Lee, Kwang Nam Kim, Ho Hyun Jeong
Clin Exp Pediatr. 2001;44(7):841-846.   Published online July 15, 2001
Acute scrotal disorders(ASD) in neonates-especially the torsion of testes- are rare, and the clinical presentations are quite different from those of adolescents or adults. The neonates with ASD are generally afebrile and do not show typical symptoms. Early diagnosis and proper treatment of ASD are very important but the differentiation of torsion and orchitis is not easy in neonates. The...
Zellweger Syndrome : First Confirmed Neonatal Case in Korea
Sung Sin Kim, Yun Hwa An, Yun Sil Chang, Dong Kyu Jin, Won Soon Park, Moon Hang Lee, Jong Won Kim, Hye Kyoung Yoon, Bo Kyoung Kim
Clin Exp Pediatr. 2001;44(6):694-698.   Published online June 15, 2001
We describe below a case of Zellweger syndrome case with facial dysmorphism, profound hypotonia, and hepatomegaly. He died at the age of 2 months. Zellweger syndrome is a disease marked by the absence of hepatic and renal peroxisomes. Because peroxisomes have many vital anabolic and catabolic functions within the cell, their absence results in profound cellular dysfunction. A biochemical study...