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Case Report
A Case of Factor Ⅶ Deficiency Presenting as Hemarthroses
Han Seong Ko, Kee Hwan Yoo, Kwang Chul Lee, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 2000;43(3):428-431.   Published online March 15, 2000
Factor Ⅶ deficiency has an estimated incidence of 1/500,000 in the general population and autosomal recessive pattern of inheritance. Factor Ⅶ deficiency is characterized by prolonged prothrombin time(PT), and normal activated partial thromboplastin time(aPTT) and bleeding time(BT). Definite diagnosis of this condition requires a specific Factor Ⅶ assay. The clinical features are variable and do not always correlate with the...
Original Article
Effects of Angiotensin Converting Enzyme Inhibition into Apoptosis and Related Genes in the Neonatal Rat Kidney
Kee Hwan Yoo, Haewon Cheon, Byung Min Choi, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1999;42(8):1086-1095.   Published online August 15, 1999
Purpose : The renin-angiotensin system plays an important role in renal growth and development. Exposuring the neonate to angiotensin converting enzyme(ACE) inhibitor increases mortality and results in growth retardation and abnormal renal development. ACE inhibition in the developing kidney reduces the renal expression of TGF-β1 and EGF, which may account for renal growth impairment. This study was designed to...
Clinical Efficiency of Cardiac Troponin T for Myocardial Damage in Neonatal Asphyxia
Nam Soo Kang, Jae Kyun Yoon, Chang Sung Son, Joo Won Lee, Young Chang Tokgo, Sang Hee Kim
Clin Exp Pediatr. 1999;42(2):195-202.   Published online February 15, 1999
Purpose : The aim of this study was to evaluate the clinical efficiency of cardiac troponin T (cTnT) in detecting myocardial damage in neonatal asphyxia and to compare the diagnostic value of cTnT with creatine kinase MB(CK-MB). Methods : Sixty-three neonates were enrolled in this study, consisting of 27 asphyxiated infants (asphyxiated group; 1-min or 5-min Apgar score≤6) and 36 healthy...
Study of a Comparison of Ultrasonography with Radiography to Localize the Umbilical Arterial Catheter
Byoung Min Choi, Young Kwan Park, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1998;41(12):1650-1659.   Published online December 15, 1998
Purpose : This study was performed to observe the utilization of ultrasonography in locating the position of UAC and to compare the position with anatomical landmarks seen on radiography. Methods : Optimal position is when the catheter tip is located between T6-T10 or L3-L5 by anteroposterior radiography(AP-R) and above the diaphragm by cross-table lateral radiography(CTL-R). Ultrasonographic studies used a Hewlett Packard...
The Effect of Steroid Therapy on Growth and Bone Density in Children with Nephrotic Syndrome
Seong Hoi Jeon, Ae Yeon Lim, Young Kook Kim, Hae Won Cheon, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1998;41(10):1396-1402.   Published online October 15, 1998
Purpose : Long-term steroid therapy for various glomerular disorders in children has been known to decrease serum Vit D3 level and develop osteomalacia. The aim of this study was to observe the effect of long-term steroid therapy on growth and bone density in children with nephrotic syndrome. Methods : Bone density of 17 steroid-treated nephrotic syndrome was compared with that of...
Thyroid Function Studies in Patients Who Underwent Open Heart Surgery
Hyung Joo Sohn, Yu In Park, Chang Sung Son, Joo Won Lee, Young Chang Tockg
Clin Exp Pediatr. 1998;41(9):1250-1255.   Published online September 15, 1998
Purpose : Alteration in the serum level of thyroid hormone can occur following open heart surgery due to major stress and hemodilution after extracorporeal circulation but these changes have been ignored. The purpose of this study is to evaluate the changes of thyroid hormone level after open heart surgery and if these changes influence the prognosis. Methods : We evaluated 26...
Prognostic Factors for Mortality in Neonates with Respiratory Distress Syndrome After Surfactant Replacement Therapy
Nam Soo Kang, Byung Min Choi, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1998;41(9):1188-1197.   Published online September 15, 1998
Purpose : To evaluate the association between neonatal mortality and the initial response to surfactant replacement therapy, and to examine the correlation between the response type and other prognostic factors. Methods : Sixty-seven neonates with respiratory distress syndrome(RDS) were divided into two groups; group I(n=51) who survived and group II(n=16) who died within the first 28 days of life after one...
Indomethacin-induced Changesin Renal Blood Flow and Prostaglandin E Excretion in the Cat
Yoon Suck DSuh, Dae Hun Pee, Jae Young Kim, Yu In Park, Kee Hwan Yoo, Joo Won Lee
Clin Exp Pediatr. 1997;40(9):1275-1284.   Published online September 15, 1997
A Study of Tubular Fluid Effects to Dysmorphic Urinary RBCs in Glomerular Hematuria
Byung Min Choi, Hyun Joo Kwak, Kee Hwan Yoo, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1996;39(4):512-521.   Published online April 15, 1996
Purpose : Urinary red blood cell morphology has been used to localize the site of hematuria in the urinary tract. But the pathologic mechanism for dysmorphic urinary red blood cells remains undefIned. Our study was undertaken to investigate the mechanism of dysmorphic urinary RBCs in glomerular hematuria. We have attempted to reproduce in vitro the changes that occur in red cell...
The Effect of ACTH on Mouse Heart
Sang Young Seo, Joo Won Lee, Chang Sung Son, Young Chang Tockgo
Clin Exp Pediatr. 1995;38(6):804-810.   Published online June 15, 1995
Purpose : Adrenocorticotropic Hormone(ACTH) therapy is useful in the treatment of patients with infantile spasm. However, serious side effects including Cushing syndrome, infections, hypertension, and electrolyte imbalance must be encountered. Moreover, hypertrophic cardiomyopathy in association with ACTH therapy has recently reported. We performed thiw study to evaluate the effect of ACTH on heart muscle. Methods : We administered ACTH subcutaneously to...
A Study of Bone Marrow Density in Korean Children of Normal Growth and Development
Byung Yoen Kim, Young Guk Kim, Young Jun Kim, Kee Hwan Yoo, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1995;38(5):612-618.   Published online May 15, 1995
Bone mineral densitometry is a useful procedure for the early detection of metabolic bone diseases and bone density changes caused by long term drug use. Dual energy X-ray absorpt- iometry(DEXA), a recently developed diagnostic radiologic method for evaluating bone mineral density is widely used because of its high sensitivity, easily obtaine results. and low dose radi- ation exposure. The study...
Serum Lipids in Children and Adolescents with Family History of Coronary Artery Diseases
Kee Hyoung Lee, Chang Sung Son, Joo Won Lee, young
Clin Exp Pediatr. 1995;38(4):482-492.   Published online April 15, 1995
Purpose : Atherosclerotic change begins in childhood, elevated blood lipid levels and a family history of premature coronary vascular diseases are important risk factors for coronary artery disease. Identification, follow-up and treatment of children at high risk of cardiovascular diseases are very effective and important for prevention of future coronary artery diseases. The purpose of this study is to determine...
Doppler Analysis of Renal Blood Flow in Normal Children
Hyun Joo Kwak, Jae Yong Kim, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee
Clin Exp Pediatr. 1995;38(3):328-338.   Published online March 15, 1995
Purpose : Recent development in ultrasonic Doppler instrumentation have allowed the direct noninvasive assessment of human renal artery blood flow. The authors conducted this study to assess noninvasive characterization of normal renal artery blood flow variables hopping to establish standards in normal children. Methods : A total 97 normal Subjects(below the age 3 years) were examinated using by 2-D and...
Case Report
A Case of Type V Hyperlipoproteinemia
Yo Ahn Rho, Jong Kwang Lee, Kee Hwan Yoo, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1994;37(12):1752-1756.   Published online December 15, 1994
The hyperlipoproteinemias are the disturbance of lipid transport resulted from accelerated synthesis or retarded degradation of lipoproteins that transport cholesterol and trigycerides through plasma. These diseases are classified as type I, type IIa, type IIb, type III, type IV, type V, and hyper-α-triglyceride levels due to increases in both VLDL and chylomicrons and lipoprotein electrophoresis shows increases pre-β, β, and...
Original Article
EEG Abnormalities in Henoch-Schölein Purpura
Hae Wom Cheon, Dong Gun Park, Kee Hwan Yoo, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1994;37(11):1600-1606.   Published online November 15, 1994
Schölein-Henoch purpura is a generalized small vessel vasculitis characterized by non-thrombocytopenic purpura, arthritis, abdominal pain and nephritis. In 1913 Osler described an allergic purpura associated with hemiplegia. After then Lewis et al. Reported the cases of Schölein-Henoch purpura associated with convulsion, coma, confusion, intracranial hemorrhage, and chorea, CNS complication has been reported in 1-8% of children and subsided spontaneously in...
Case Report
A Case of Miescher Syndrome with Insulin-Resistant Diabetes Mellitus
Byung Min Choi, Jong Kwang Lee, Kee Hwan Yoo, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1994;37(9):1292-1295.   Published online September 15, 1994
Miescher syndrome comprises congenital acanthosis nigricans, hypertrichosis, failure to thrive and short stature, dysmorphism especially of the jaws and oral cavity. Insulin-resistant diabetes mellitus, and a characteristic general appearance. This report concerns a rare case of 12-year-old girl having insulin resistant diabetic mellitus with Miescher syndrome. The relevant literature was reviewed.
Original Article
The Effect of Long-term Phenobarbital Administration on the Bone Mineral Density of Children
Yoon Suck Suh, Young Guk Kim, Jung Hwa Lee, Kee Hwan Yoo, Joo Won Lee, Young Chang Tockgo
Clin Exp Pediatr. 1994;37(3):368-375.   Published online March 15, 1994
The long term administration of anti-convulsants on children with convulsive disorders may cause osteomalacia, depending on the dosage, duration, type and combination of anti-convulsants administred. Fifteen children, comprising 10 male and 5 female, dignosed with convulsive disorders and administered with phenobarbital for a long term period of more than 9 months but less than 84 months and 15 healthy children...
The Metabolic Acidosis and Clinical Outcome in Acute Infantile Diarrhea
Ae Yeon Lim, Yo Ahn Rho, Kee Hwan Yoo, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1994;37(3):332-338.   Published online March 15, 1994
To determine the types of metabolic acidosis using anion gap in acute infantile diarrhea and to correlate it with clinical outcome, we examined 103 infants admitted with acute diarrhea. The serum electrolytes (sodium, potassium, chloride, phosphorus), creatinine, CO2 content and anion gap were measured on first admission day. They were classified group A with normal anion gap (8~16 mEq/L) and...
A Clinical Survey of Prolonged Q-T Syndrome among Korean Children with Congenital Deafness
Kang Woo Lee, Kyung Bum Kim, Chang Sung Son, Joo Won Lee, Young Chang Tockgo
Clin Exp Pediatr. 1993;36(9):1236-1244.   Published online September 15, 1993
The clinical symptom complex characterized by syncopal attacks and sudden death in patients with electrocardiographic anomalies, especially a prolonged Q-t interval is known as the Romano-Ward syndrome. When a similar syptom complex is accompanied by congenital deafness, it is called Jervell and Lange-Nieisen syndrome. This study was underataken to investigate the incidence of the latter syndrome in the...
A Clinical Study on Febrile Convulsion
Jung Hwan Lee, Ki Hwan Yoo, Yong Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1993;36(6):850-857.   Published online June 15, 1993
Although febrile convulsion(FC) is a common clinical entity with a high recurrence rate, no specific factors have been identified to be highly predictive of its recurrence. A total to 114 cases of FC identified during a 28 month period (January, 1989-May, 1991) was analysed. A silght predominance of boys over girls(1.3 to 1.0) was observed. The majority of cases(89.4%) were under 3...
Clinical Assessment of Neonatal Transient Tricuspid Insuffieciency - Doppler Echocardiographic Study-
Se Geun Park, Dong Gun Park, Ji Hee Park, Chang Sung Son, Joo Won Lee, Young Chang Tockgo
Clin Exp Pediatr. 1993;36(6):785-790.   Published online June 15, 1993
Eight neonates with transient tricuspid insufficiency are presented which was confirmed clinical and two dimensional echocardiographic assessment. We found that two dimensional Doppler echocardiography was very useful in the detection of transient tricuspid insufficiency during neonatal age as noninvasive method. Transient tricuspid insufficiency is a clinical disorder in the newborn period caused by myocardial dysfunction, secondary to asphyxia with or without...
Obesity in Elementary School Children
Ji Hee Park, Chang Sung Son, Joo Won Lee, Young Chang Tockgo
Clin Exp Pediatr. 1993;36(3):338-346.   Published online March 15, 1993
Obesity has been implicated as a significant risk factor for multiple medical condition including hypertention, glucose intolerance, hyperlipidemia, hyperisulinemia and fatty liver. Furthermore, obesity in childhood is believed to be a reliable predictor of a similar condition in adulthood. During the recent yars, there has been a rapid rise in the incidence of childhood obesity in Korea due to increased...
A Clinical Study on Early Diagnosis in Neonatal Sepsis
Jong Kwang Lee, Hae Won Cheon, Jee Hee Park, Jung Hwa Lee, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1993;36(1):49-56.   Published online January 15, 1993
Neonatal sepsis is a major contributing factor for increased mortality and morbidity in the newborn and its successful outcome depends on early detection and prompt institution of an effective antimicrobial therapy. Accurate diagnosis of the neonatal septicemia, however, is quite difficult because its early signs and symptoms are rather subtle. This study was conducted in an attempt to search for useful...
A Cause of Transient Systolic Murmur in Neonates Physiologic Pulmonary Artery Stenosis
Hyun Joo Kwak, Phil Seob Sim, Kwang Chul Lee, Chang Sung Sohn, Joo Won Lee, Young Chang Tockgo
Clin Exp Pediatr. 1992;35(12):1696-1701.   Published online December 15, 1992
A transient heart murmur is frequently heard in normal newborn who has no congenital heart disease. The cause of this murmur remains unclear but was speculated as hypoplasia of the pulmonary arterial branches or unusual alignment of the main pulmonary artery with its branches. Pulsed Doppler and two-dimensional echocardiographic studies were undertaken in 19 newborn infants with a transient murmur and...
Clinical Evaluation of Reactive Thrombocytosis in Childhood
Yoon Suck Suh, Young Yoo, Kwang Chul Lee, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1992;35(5):607-613.   Published online May 15, 1992
The platelet coiunt has not been part of routine hematologic profiles until recently, when the newer electronic blood cell counters began to include platelet count with all other blood cell counts. With the widespread use of newer generation electronic blood cell counters, elevated platelets coiunts are being encountered more ofter in pediatric practice. We reviewed all cases of marked thrombocytosis to...
Case Report
An Autopsy Case of Infant of Diabetic Mother with d-Transposition of Great Arteries and Hypertrophic Cardiomyopathy
Kye Hwan Seol, Eui Kyeung Jung, Chang Sung Son, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1992;35(4):545-550.   Published online April 15, 1992
Generally, infants of diabetic mother(IDM) have various diseases and complications affecting multisystems resulting in high perinatal morbidity and mortality. It is well known that IDM have especially higher incidence of congenital anomalies including congenital heart disease(CH D). dTransposition of great arteries(d-TGA), ventricular septal defect and hypertrophic cardiomyopathy(HCM) form most of CHD occurring in IDM. Of these, HCM appears as a...
Original Article
The Effect of Prostaglandin E1 Infusion for Palliation of Ductus Dependent Cyanotic Congenital Heart Disease in Neonates
Ji Hee Park, Chang Sung Son, Joo Won Lee, Young Chang Tockgo
Clin Exp Pediatr. 1992;35(3):364-370.   Published online March 15, 1992
Prostaglandin E1 (PGE1) was administered to 12 neonates with cyanotic congenital heart disease in whom pulmonary or systemic blood flow were entirely or significantly dependent on persistent patency of the ductus arteriosus. 10 neonates responded favorably to PGE1, by showing significant increase of PaO2 after PGE1 infusion but remaining 2 neonates with hypoplastic left heart syndrome failed to respond. The...
Pulsed doppler echocardiographic analysis of pulmonary venous flow in congenital heart diseases with left-to-right shunt.
Kye Hwan Seol, Chang Sung Son, Joo Won Lee, Soon Kyum Kim, Young Chang Tockgo
Clin Exp Pediatr. 1991;34(7):934-939.   Published online July 31, 1991
Pulsed Doppler echocardiography was performed to evaluate the flow velocity pattern of the pulmonary vein in 28 patients with congenital heart diseases which comprised of 8 atrial septal defect (ASD), 14 ventricular septal defect (VSD) and 6 patent ductus arteriosus (PDA). 20 normal children served as controls. The objective of this study was to ascertain that pulmonary venous flow velocity is dependent on the...
Clinical study of supraventricular tachycardia in children.
Eui Kyung Chung, Yun Seok Suh, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1991;34(6):796-804.   Published online June 30, 1991
Supraventricular tachycardia is the most symptomatic dysrhythmia encountered in infants and children. Recognition of the dysrhythmias is of great clinical importance, since increasing number of infants will develop congestive heart failure and occasionally circulatory collapse. Retrospective study was done in 17 patients with supraventricular tachycardia, who were admitted to our hospital from 1983 to 1989. The results were as follows: 1) 47 percent of our patients with...
Acute hemodynamic effects of increasing hemoglobin concentration in children with congenital heart disease and relative anemia.
You In Park, Young You, Chang Sung Son, Joo Won Lee, Young Chang Tocko
Clin Exp Pediatr. 1991;34(6):787-795.   Published online June 30, 1991
The short-term effects of increasing hemoglobin concentration were evaluated on cardiac catheter- ization in nine patients with congenital heart diseases and relative anemia. Diagnosis were ventricular septal defect in six, tetralogy of Fallot in two, and endocardial cushion defect in one. Various hemodynamic data including pulmonary and systemic blood flow, pulmonary and systemic vascular resistance and the degree of shunt were compared before and...