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Original Article
Effects of Partial Liquid Ventilation on Gas Exchange, Hemodynamics, and Pulmonary Function in Newborn Piglet with Respiratory Distress
Yun Sil Chang, Won Soon Park
Clin Exp Pediatr. 2000;43(11):1430-1439.   Published online November 15, 2000
Purpose : To evaluate gas exchange, hemodynamics and pulmonary function during partial liquid ventilation(PLV) using PFC(perfluorodecalin), compared with conventional gas ventilation in newborn piglets with saline lavage-induced respiratory distress. Methods : In a total of 16 instrumented and ventilated piglets, acute respiratory distress(below 70 mmHg of PaO2 at FiO2 1.0) was induced by repeated saline pulmonary lavage. The piglets were randomized...
Neonatal Systemic Candidiasis : Comparison of Albicans and Parapsilosis Infection
Jung Mie Han, Ho Young Lee, Mi Jeong Kang, Sun Young Ko, Yun Sil Chang, Won Soon Park
Clin Exp Pediatr. 2000;43(8):1052-1058.   Published online August 15, 2000
Purpose : Systemic Candidiasis has become an increasingly important cause of morbidity and mortality in NICU infants. Severe infections caused by non-albicans Candida species have been increasingly reported in NICU infants. The purpose of the present study was to compare relative severity, mortality rates for C. albicans(CA) and C. parapsilosis(CP) infections in our NICU. Methods : This study included 16 infants...
Delayed Cerebral Energy Failure After Acute Hypoxia-Ischemia in Neworn Piglet Under 48hours of Continuous Monitoring Using Near-Infrared Spectroscopy
Yun Sil Chang, Won Soon Park, Munhyang Lee, Ki-Soo Kim, Jung-Hwan Choi, Son Moon Shin
Clin Exp Pediatr. 1998;41(9):1198-1210.   Published online September 15, 1998
Purpose : To test the hemodynamic and biochemical sequences of secondary cerebral energy failure after acute reversed hypoxic ischemic brain insult(HI) can be reproduced in newborn piglets. Methods : Fifteen anesthetized, ventilated newborn piglet(<3 day) were studied. Eight(HI) were induced transient HI by breathing 8% oxygen and complete occlusion of bilateral common carotid arteries for 30 minutes followed by reoxygenation...
High Frequency Oscillatory Ventilation as a Rescue Therapy of Severe Neonatal Respiratory Failure
Eun Kyung Lee, Yun Sil Chang, Won Soon Park
Clin Exp Pediatr. 1998;41(4):456-465.   Published online April 15, 1998
Purpose : High frequency oscillatory ventilation(HFOV) using suprathysiologic ventilatory frequency is a new therapeutic technique, which has a improved survival and reduced complication of newborn infants suffering from severe respiratory failure. The aim of this study was to assess the efficacy of HFOV as a rescue therapy for infants with severe respiratory failure and to compare the treatment results...
Hemodynamic Effect of Nitric Oxide Inhalation in the Acute Hypoxic Pulmonary Hypertension Induced Newborn Piglet
Yun Cil Chang, Won Soon Park, Jung-Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1997;40(10):1394-1409.   Published online October 15, 1997
Purposes : Nitric oxide(NO) is classified as toxic gas in native states, but in most biologic systems NO acts as a messenger molecule. NO is known as endothelium derived relaxing factor that modulates tone of vascular smooth muscle. Inhaled NO has been reported to act as a selective pulmonary vasodilator and we expect that NO inhalation can be used as a successful treatment modality...
Case Report
Two Cases of Nitric Oxide Inhalation for Treatment of Severe Pulmonary Hypertension after Surgical Repair of Congenital Diaphragmatic Hernia
Yun Sil Chang, I-Seok Kang, Won Soon Park, Suk Koo Lee, Hun Hahk Kim, Heung Jae Lee
Clin Exp Pediatr. 1996;39(11):1611-1619.   Published online November 15, 1996
Nitric oxide, an endothelium-derived relaxing factor, is a selective pulmonary vasodilator. We have built and settled down the delivery system of nitirc oxide gas inhalation for the first time in Korea. Two newborn babies delvelped near fatal pulmonary hypertension after surgical repair of a congenital diaphragmatic hernia. All conventional therapeutic measures failed. So we decided to attempt to use of nitric oxide gas for...
Original Article
Genital Mycoplasmasin the Newborn Infants: Colonization, Prevalence and Clinical Significance
Yun Sil Chang, Sung Gwon Kim, Beyong Il Kim, Won Soon Park, Bo Hyun Yoon, Eui Chong Kim, Jung-Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1996;39(8):1084-1094.   Published online August 15, 1996
Purpose : The genital mycoplasmas: Ureaplasma urealyticum and Mycoplasma hominis have recently assumed an increasing importance as neonatal pathogens especially in preterm infants. The aim of the present study was to determine the prevalence of infections with these organisms in newborn infants who were admitted in Neonatal Intensive Care Unit(NICU) and who were suspected having infection in newborn nursery Methods : Sixty four inborns who...
Medical Lecture Course
Clinical Applications of Near Infrared Spectroscopy
Won Soon Park
Clin Exp Pediatr. 1996;39(5):595-602.   Published online May 15, 1996
Original Article
Congenital cystic diseases of the lung.
Won Soon Park, Young Pyo Chang, Hee Ju Kim, Young Yull Koh, Jung Hwan Choi, Chong Ku Yun, Joo Hyun Kim
Clin Exp Pediatr. 1991;34(12):1671-1677.   Published online December 31, 1991
Congenital cystic diseases of the lung (CCDL) is a clinical group of disorders characterized by a cystic appearance of pulmonary tissue. It can be classified into four distinct categories: 1) Congenital lobar emphysema (CLE), 2) Congenital cystic adenomatoid malformation (CCAM), 3) Pulmonary sequeestration (PS), and ^Bronchogenic cyst (BC). 24 patients with CCDL admitted to the Seoul National University Children’s Hospital from January 1984 to June...
Mechanical ventilator care in the newborn infants.
Young Pyo Chang, Yong Won Park, Won Soon Park, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1991;34(11):1526-1533.   Published online November 30, 1991
The widespread introduction of mechanically assisted ventilation into the neonatal intensive care during the 1960s substantially improved the outcome of sick newborn infants, particularly those with respiratory disorders. We studied the clinical features of 82 neonates, who were treated with mechanically assisted ventilation in Neonatal Intensive Care Unit (NICU) at Seoul National Univer- sity Children’s Hospital from January 1986 to August 1989 (the second...
A case of pulmonary vascular air embolism in the newborn.
Won Soon Park, Beom Soo Park, Hye Kyung Han, Jung Hwan Choi, Chong Ku Yun, Kyoung Mo Yeon, Je Geun Chi
Clin Exp Pediatr. 1991;34(10):1422-1427.   Published online October 31, 1991
Pulmonary vascular air embolism is a rare, and almost invariably fatal complication of positive pressure ventilation of newborn infants. There have only been 53 cases described in the world literature to date. We have experienced a case of pulmonary vascular air embolism in a premature newborn as a complication of mechanical ventilation during the course of respiratory distress syndrome. The pathophysiology and clinical characteristics of...
Clinical Observation on Juvenile Rheumatoid Arthritis.
Won Soon Park, Kwang Wook Ko
Clin Exp Pediatr. 1986;29(2):152-162.   Published online February 28, 1986
A clinical observation on 70 patients of juvenile rheumatoid arthritis who were admitted to S.N.U.H. during the 6 year period from Jan. 1979 to Dec. 1984, was assessed. The results were as follows; 1) On type classification, systemic type(37.2%) was most frequent, followed by RF negative polyarticular type, pauciarticular type H, RF positive polyarticular type and pauciarticular type I in order of frequency. The...