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Original Article
Epidemiology and Clincal Analysis of Acute Viral Respiratory Tract Infections in Children(September, 1998-May, 2003)
Su-Jin Lee, Eon-Woo Shin, Eun-Young Park, Phil-Soo Oh, Kwang-Nam Kim, Hae-Sun Yoon, Kyu-Man Lee
Clin Exp Pediatr. 2005;48(3):266-275.   Published online March 15, 2005
Purpose : Acute respiratory tract infections are the most common illnesses in children. The great majority of these infections involving lower respiratory tracts infections(LRTIs) are caused by respiratory viruses such as respiratory syncytial virus(RSV), parainfluenza virus(PIV), influenza virus (Flu), and adenovirus(ADV), etc. Our purpose was to determine seasonal epidemiology and clinical characteristic features of each viral infection. Methods : Nasopharyngeal aspirate(NPA)s...
Clinical Lecture
Acute infectious Diarrhea in Pediatirc Patients
Sang Hyuk Ma
Clin Exp Pediatr. 2005;48(3):235-250.   Published online March 15, 2005
Acute diarrhea is one of the most common diseases that are seen in pediatric patients. In the management of acute diarrhea, several differential diagnostic criteria should be considered based on clinical and/or laboratory findings. These criteria include : ① normal variant stool versus diarrhea ② infectious versus non-infectious condition and ③ bacterial versus non-bacterial etiology. The use of antibiotics should...
Original Article
Allogeneic Hematopoietic Stem Cell Transplantation in Juvenile Myelomonocytic Leukemia
Keon Hee Yoo, Dong Kil You, Soo Hyun Lee, Ki Woong Sung, Eun Joo Cho, Hong Hoe Koo
Clin Exp Pediatr. 2005;48(2):178-185.   Published online February 15, 2005
Purpose : The purpose of this study was to evaluate the outcome of children with juvenile myelomonocytic leukemia(JMML) treated with allogeneic hematopoietic stem cell transplantation(allo- HSCT). Methods : Eleven JMML patients aged 8-39 months underwent allo-HSCT. The sources of grafts were unrelated donors(n=7), HLA-matched siblings(n=3) and an HLA 1-antigen mismatched familial donor. All patients had received chemotherapy ?13-cis-retinoic acid(CRA) before...
Impact of Device Evolution in Transcatheter Closure of Patent Ductus Arteriosus Using Duct-Occlud Coils : Comparison of Mid-term Results
Myung Kwan Kim, Dong Ki Han, Jae Young Choi, Yuria Kim, Byung Won Yoo, Deok Young Choi, Jun Hee Sul, Sung Kue Lee
Clin Exp Pediatr. 2005;48(2):158-164.   Published online February 15, 2005
Purpose : We reviewed the therapeutic results of various Duct-Occlud coils(pfm AG, K ln, Germany) to evaluate the efficacy of the most-recently modified Duct-Occlud coil(Nit-Occlud) in the transcatheter closure of patent ductus arteriosus(PDA), including large defects more than 4 mm in diameter. Methods : Two hundred and five patients who underwent percutaneous PDA occlusion using Duct- Occlud devices from March...
Serum and Cerebrospinal Fluid(CSF) Nitric Oxide, Macrophage Inflammatory Protein-1α and Lactoferrin Levels in Aseptic Meningitis
Young Seo, Jung Yeon Shim, Jae Won Shim, Deok Su Kim, Hye Lim Jung, Moon Soo Park
Clin Exp Pediatr. 2005;48(1):48-54.   Published online January 15, 2005
Purpose : The pathologic mechanisms of central nervous system(CNS) injuries in human meningitis are not yet completely understood. Recent studies indicate that the host inflammatory responses are as important in brain damage as the infecting organisms and toxins. There have been some reports on the relationship of nitric oxide(NO), macrophage inflammatory protein-1α(MIP-1α), and lactoferrin in bacterial meningitis, but few reports...
Penicillin Resistant Distribution and in-vitro Susceptibility of Oral Antibiotics against Streptococcus pneumoniae, isolated from Pediatric Patients with Community- Acquired Respiratory Infections in Korea
Jin Han Kang, Sun Mi Kim, Jong Hyun Kim, Hur Jae Kyun, Kyung Yil Lee, Young Ku Shin, Su Eun Park, Sang Hyuk Ma, Young Jin Hong
Clin Exp Pediatr. 2005;48(1):40-47.   Published online January 15, 2005
Purpose : S. pneumoniae is one of major pathogens of community-acquired respiratory infections. The rate of antibiotic resistance to this organism has increased, and resistance to multiple antimicrobial agents in a single strain of S. pneumoniae may compromise the efficacy of empiric antimicrobial treatment commonly used for respiratory infections. We did this study to find out the penicillin resistant distributions...
Intrauterine Intraventricular Hemorrhage in Premature Infants
Hyun-Seung Jin, Kyeng-Ah Park, Hyun-Woo Goo, Jong-Hyun Yoon, Ellen Ai-Rhan Kim, Ki-Soo Kim, Soo-Young Pi
Clin Exp Pediatr. 2005;48(1):27-33.   Published online January 15, 2005
Purpose : To determine incidence, characteristics and risk factors associated with intrauterine intraventricular hemorrhage(IU-IVH) among premature infants. Methods : The medical records of infants with intraventricular hemorrhage(IVH) admitted to the neonatal intensive care unit of Asan Medical Center from January 1999 to June 2003 were reviewed retrospectively. Infants whose IVH with cystic change were detected within five days of life were...
Case Report
Melanotic Neuroectodermal Tumor of Infancy in the Epididymis : A Case Report
Sang Bae Lee, Seong Hun Lee, Min Hyuk Ryu, Ji Seoung Park, Joo Heoun Yang, Sun Young Kim, Dong Jean Lee
Clin Exp Pediatr. 2004;47(12):1334-1337.   Published online December 15, 2004
Melanotic neuroectodermal tumor of infancy (MNTI) is a rare neoplasm known by a variety of names including melanotic progonoma and retinal anlage tumor, and currently thought to be neural crest derivation. The vast majority develop within the first year of life. The behavior is generally benign, but recurrent and metastatic cases have been documented. It arises in the head and...
Original Article
The Effects of Intravenous Immunoglobulin(IVIG) and Methylprednisolone on the mRNAs Expressions of VEGF, VCAM-1 and IL-1β of Human Umbilical Vein Endothelial Cells(HUVEC) Stimulated by IL-1β
Soh Yeon Kim, Sun Jeong Lim, Ji Whan Han, Kyung Yil Lee, Joon Sung Lee
Clin Exp Pediatr. 2004;47(12):1325-1333.   Published online December 15, 2004
Purpose : Kawasaki disease(KD) manifests a systemic vasculitis of unknown etiology in young children. Vascular endothelial growth factor(VEGF), vascular cell adhesion molecule-1(VCAM-1) and interleukin-1 beta(IL-1β) may play important roles in the pathogenesis of KD. Intravenous immunoglobulin(IVIG) and methylprednisolone(MP) are therapeutically effective for KD, however, the precise mechanisms of the two drugs are still unknown. We investigated the therapeutic efficacy of...
Urine Organic Acid Analysis of Patients with Febrile Seizures
Dong Soo Shin, Gun Jun Lee, Kyeung Ja Lee, Won Il Park, Eun Joo Bae, Hong Gin Lee
Clin Exp Pediatr. 2004;47(11):1205-1209.   Published online November 15, 2004
Purpose : Febrile seizure, the most common seizure disorder in children between 6 months and 5 years of age, is mostly caused by viral infections, except severe CNS infection. It can also be caused by disorders in organic acid metabolism, especially accompanied by fever. Therefore we decided to investigate the relationship between children with febrile seizures and disorders in organic...
The Incidence and Risk Factors of Posttraumatic Seizure in Children
Sue Youn, Mi A Lee, Hwang Min Kim, Byung Ho Cha
Clin Exp Pediatr. 2004;47(11):1198-1204.   Published online November 15, 2004
Purpose : The goal of our study was to identify the incidence and clinical, neurophysiological and neuroradiological variables with predictive value for posttraumatic seizure(PTS). Methods : The medical records of 625 children with head traumas under 15-year-old who were admitted to the Wonju Christian Hospital, from January, 1993 to January, 2002 were retrospectively reviewed. Among them, 472 patients were included...
A Clinical Study of Chronic Functional Constipation in Children Treated for more than Five Months
Young Min Kim, Sung Yun Choi, Sun Hwan Bae, Young Min Ahn
Clin Exp Pediatr. 2004;47(11):1186-1192.   Published online November 15, 2004
Purpose : The purpose of this study was to evaluate the clinical features and the courses and effects of long-term treatment, and to analyze the association between clinical features and duration of therapy in chronic functional constipation in children. Methods : This study enrolled 57 children with chronic functional constipation who were treated in the Eulji Hospital for more than...
Case Report
The VACTERL Association : Tracheal Stenosis, Tracheal Bronchus and Partial Pulmonary Agenesis, Instead of Tracheoesophageal Fistula
Ji Sook Park, Hae Young Lee, Jong Sil Lee, Ji Hyeon Seo, Jae Young Lim, Myong Bum Choi, Chan Hoo Park, Hyang Ok Woo, Hee Sang Youn
Clin Exp Pediatr. 2004;47(10):1119-1123.   Published online October 15, 2004
VACTERL association is a disease with multiple congenital anomalies of the vertebrae, anus, cardia, tracheoesophageal(TE) fistula, renal and limb. This disease is derived from VATER anomaly, accompanied by cardiac and limb anomalies. We experienced a case of a 1-day-old boy with anal atresia, who represented multiple anomalies during hospital course. The multiple anomalies were hemivertebra, anal atresia, complex heart disease(coarctation...
Original Article
Thermogenic Response to Fasting and Exercise in Different Aged Rats
Ae Jung Kwak, Kwang Hae Choi, Yong Hun Park, Yong Woon Kim
Clin Exp Pediatr. 2004;47(10):1100-1105.   Published online October 15, 2004
Purpose : Recently, there has been a marked increase in childhood obesity, and that has aroused social concern. Obesity increases several metabolic disease such as hypertension, diabetes, fatty liver, heart disease and the mortality rate. Complications of obesity are more closely related with the accumulation of visceral fat. Therefore, fundamental treatment of obesity Should be the reduction of body fat....
Pulmonary Function of Patients with Adolescent Idiopathic Scoliosis
Yu Sok Han, Hyun Ah Kim, Uee Ryoung Chung
Clin Exp Pediatr. 2004;47(10):1076-1080.   Published online October 15, 2004
Purpose : To evaluate the patterns of preoperative pulmonary function tests(PFTs) and their correlation with postoperative pulmonary impairment in patients with adolescent idiopathic scoliosis(AIS), who had orthopaedic operation with or without rib resection thoracoplasty. Methods : The case records and radiographs of 79 patients(12, boys and 67, girls) of a mean age of 13.3 years(7-15 years) with AIS who underwent orthopaedic...
Causative Organisms of Urinary Tract Infection in Children, and their Antibiotic Susceptibility
Yoon Duk Kang, Nam Su Kim, Sung Hee Oh
Clin Exp Pediatr. 2004;47(10):1065-1071.   Published online October 15, 2004
Purpose : In caring patients with urinary tract infection(UTI), it is prominent to know causative agents and their antimicrobial susceptibilities, of which domestic data appear somewhat different from those reported in the literature. The study was done to learn the distribution of pathogens causing UTI and their antimicrobial susceptibilities in Korean children. Methods : One hundred forty two inpatients diagnosed...
Clinical Lecture
Clinical Approach to the Children with Coagulation Deficiencies
Sang Kyu Park
Clin Exp Pediatr. 2004;47(10):1036-1040.   Published online October 15, 2004
This review deals with the coagulation deficiencies which are due to the abnormality in one of three hemostatic systems. It explains about the diagnostic examinations that should be done to differentiate for patients with bleeding tendency and the things to consider when preoperative screening tests for coagulation are abnormal.
Medical Lecture Course
Factors Involved in Lung Development and Alveolarization
Min Soo Park
Clin Exp Pediatr. 2004;47(10):1031-1035.   Published online October 15, 2004
Lung development is a sum of processes that involve harmonized orchestration of expressions of various factors in time and space. The mastermind governing these phenomena is not known, but cumulative efforts so far have helped us gain some insights as to what are involved in and how complex the developmental process is. Beginning as primitive foregut, lungs undergo processes called...
Case Report
A Case of Rhizomelic Chondrodysplasia Punctata Occurring in Siblings
Soon Hwa Yoon, Nam Young Kim, Seon Hee Shin, Sung Koo Kim, Kon Hee Lee, Hae Sun Yoon, Jung Eun Kim
Clin Exp Pediatr. 2004;47(9):1016-1019.   Published online September 15, 2004
Chondrodysplasia punctata is a group of heterogeneous bone dysplasia characterized by punctate calcifications of the cartilage, frequently associated with a shortening of the limbs, cataracts, icthyosis and alopecia, alterations of the nervous system, and mental and growth deficiencies. Our case presented findings of the rhizomelic chodrodysplasia punctata : a characteristic face, a sucking difficulty and a short neck. Skeletal radiographies...
Original Article
Surfactant Therapy for Neonatal Respiratory Distress Syndrome : Experience in Korea Over 15 Years
Chong-Woo Bae, Young-Min Kim
Clin Exp Pediatr. 2004;47(9):940-948.   Published online September 15, 2004
Purpose : Surfactant replacement therapy in neonates with respiratory distress syndrome(RDS) has been used in Korea since 1990. We undertook a collective study of trials from multi-hospitals to evaluate results of neonates with RDS who were treated with surfactant during the past 15 years in Korea(Period I, P-I, 1990-91; Period II, P-II, 1996; Period-III, P-III; 2002). Methods : There were 60...
Case Report
A Case of Solitary Rectal Ulcer Syndrome
Won Ho Hahn, Eun Seong Kim, Hyo Jong Kim, Sung Ho Cha
Clin Exp Pediatr. 2004;47(8):896-899.   Published online August 15, 2004
Solitary rectal ulcer syndrome(SRUS) is a rare disorder in children. The incidence of SRUS is highest in young adults, and sex distribution is equal, or there may be a slight female predominance. There are few investigations about the exact incidences and effective treatment protocols of SRUS in children. The clinical symptoms and signs of SRUS are accompanied by rectal bleeding,...
Original Article
The Tumor Suppressor Function of PTEN/MMAC1 through the Regulation of IGFs and IGFBPs
Ho Keun Yi, Dong Jin Hwang, Sun Young Kim, Dae Yeol Lee, Pyoung Han Hwang
Clin Exp Pediatr. 2004;47(8):884-891.   Published online August 15, 2004
Purpose : PTEN/MMAC1, a novel tumor suppressor gene, is mutated in a variety of advanced and metastatic cancers. It acts as a phosphatase, and thereby, regulates the PI-3 kinase/Akt pathway. In this study, we examined to evaluate the new function of anti-tumor effects of PTEN/MMAC1 through the regulation of the IGFs-IGFBPs in gastric cancer cells. Methods : PTEN/MMAC1 was expressed in...
Follow-up Studies and Clinical Significance of Chromosomal Rearrangement in Childhood Acute Lymphocytic Leukemia
Yang Hyun Kim, Jung Tae Kim, Jung Chul Kang, Hae Sik Kwon, Sung Chul Won, Seung Hwan Oh, Chuhl Joo Lyu
Clin Exp Pediatr. 2004;47(8):861-867.   Published online August 15, 2004
Purpose : Through routine screening for chromosomal defects present in patients with acute lymphocytic leukemia(ALL) by means of reverse transcription-polymerase chain reaction(RT-PCR), we aimed for earlier detection of recurrences, hence evaluating the progress of the disease after treatment, and forecasting the need for further testing. Methods : We analyzed 30 patients who visited the Pediatrics Department of Severance Hospital, from...
A Clinical Study of Infective Endocarditis in Childhood
Eun Na Choi, Jae Hun Kwon, Kyong Min Choi, Hwan Dae Hwang, Kyoung Mi Sin, Jae Young Choi, Jun Hee Sul, Dong Su Kim
Clin Exp Pediatr. 2004;47(8):844-850.   Published online August 15, 2004
Purpose : Advances in the treatment of congenital heart disease and a decline in the incidence of rheumatic fever has led to changes in the causative organisms and the clinical outcome of infective endocarditis(IE). We sought to analyze the clinical outcome, prognostic factors, causative organisms and corresponding antibiotic sensitivity in IE. Methods : Retrospective analysis of medical records of 104 children...
Protein C as a Differential Marker for Bacterial Infection among Pediatric Patients with Fever
Eun Ha Mo, In Hae Nam, Kyung Duk Park
Clin Exp Pediatr. 2004;47(8):839-843.   Published online August 15, 2004
Purpose : This study was performed to find the clinical significance in protein C as a differential marker in the beginning stage of infection and prognosis factor in severe infection among pediatric patients who were admitted due to fever. Methods : A total of 40 pediatric patients who had temperatures higher than 37.5℃ on admission at the Department of Pediatrics,...
The Change in Intestinal Lactobacillus Count among Healthy Neonates
Hyun Joo Lee, Hyun Ji Lee, Su Jin Cho, Jung Wan Seo, Seung Joo Lee, Eun Ae Park
Clin Exp Pediatr. 2004;47(8):833-838.   Published online August 15, 2004
Purpose : Enhancing overall health by preventive and therapeutic use of probiotics has shown great promise on inflammatory, infectious, neoplastic disorders, allergies, et al. To attain preliminary data for the use of probiotics, we have studied the change in intestinal flora, Lactobacillus count among healthy, full term neonates. Methods : Fresh stool samples were collected on the 2nd or 5th day...
Case Report
A Case of Neonatal Hydrometrocolpos Accompanying Urinary Tract Obstruction
Kyoung Eun Lee, Ok Yeon Cho, Eun Jung Sim, Do Jun Cho, Dug Ha Kim, Ki Sik Min, Ki Yang Yoo, Guan Sup Lee
Clin Exp Pediatr. 2004;47(7):789-793.   Published online July 15, 2004
Neonatal hydrometrocolpos is the cystic dilatation of the vagina and uterus, which is caused by the combination of vaginal obstruction such as imperforate hymen, transverse vaginal septum, or vaginal atresia, and glandular secretion by maternal estrogenic stimulation. Although hydrometrocolpos is a rare congenital abnormality unlike pubertal hematocolpos, it is one of the relatively common abdominal masses in neonates. In typical...
Original Article
Effect of Histone H1 on Collagen Induced Arthritis in Mice
Jae Ho Yang, Kyung Mi Shin, Dong Soo Kim
Clin Exp Pediatr. 2004;47(7):779-788.   Published online July 15, 2004
Objective : Besides the functions of histones in the nucleus of the cells, there is growing evidence that histones have many other extra-cellular or extra-nuclear functions, such as stabilizing axonemal microtubule of sea urchin sperm flagella. This microtule assembly function of the histone is similar to that of taxol, which has an effect of controlling joint inflammation. In this study,...
Methylenetetrahydrofolate Reductase(MTHFR) Gene Expression in Kawasaki Disease
Hye Ryung Choi, Ae Ra Joo, Hae Soon Kim, Sejung Sohn, Young Mi Hong
Clin Exp Pediatr. 2004;47(7):774-778.   Published online July 15, 2004
Purpose : Hyperhomocysteinemia is known as an independent risk factor for cardiovascular diseases such as atherosclesosis and myocardiac infarct. A common mutation in 5, 10-methylenetetrahydrofolate reductase(MTHFR) gene results in a valine for alanine substitution, which makes enzyme thermolabile and reduces enzymal activity. We examined the relation of MTHFR genetic mutation and Kawasaki disease. Methods : We extracted DNA from the peripheral...
Colonic Polyps; Experience of 34 Cases in Two Hospitals
Seoung Joon Kim, Sun Mi Kim, You Jeong Kim, Dae Chul Jeong, Won Bae Lee, Seung Yun Chung, Jin Han Kang
Clin Exp Pediatr. 2004;47(7):756-761.   Published online July 15, 2004
Purpose : Colonic polyps are among the most common causes of rectal bleeding in children. We studied the clinical spectrum, histology, malignant potential and treatment of colonic polyps in our cases. Methods : We reviewed hospital charts of all patients with colonic polyps, seen over a 15-year period from January 1988 to November 2002. Colonoscopy and/or barium enema were done for...