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- Review Article
- 2007 Korean National Growth Charts: review of developmental process and an outlook
- Jin Soo Moon, Soon Young Lee, Chung Mo Nam, Joong-Myung Choi, Bong-Keun Choe, Jeong-Wan Seo, Kyungwon Oh, Myoung-Jin Jang, Seung-Sik Hwang, Myung Hwan Yoo, Young Taek Kim, Chong Guk Lee
- Clin Exp Pediatr. 2008;51(1):1-25. Published online January 15, 2008
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Purpose : Since 1967, The Korean Pediatric Society and Korean Government have developed Korean Growth Standards every 10 years. Last version was published in 1998. During past 40 years, Korean Growth Standards were mainly descriptive charts without any systematic nor statistical standardization. With the global epidemic of obesity, many authorities such as World Health Organization (WHO) and United States' Centers... -
- Original Article
- Influence of vascular endothelial growth factor (VEGF) and endostatin on coronary artery lesions in Kawasaki disease
- Seon A Kim, Bum Suk Jung, Jong Seo Yoon, Ji Whan Han, Joon Sung Lee
- Clin Exp Pediatr. 2007;50(12):1241-1246. Published online December 15, 2007
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Purpose: Recently, there has been several studies to clarify the pathogenesis of Kawasaki disease (KD) and the relations of VEGF and endostatin that act on vascular endothelial cells to the coronary artery complications. In this report, we measured serum levels of VEGF and endostatin in acute and subacute phases of KD to assess the change of these levels and the... -
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- The clinical manifestations, the short- and long-term outcomes of Bartter syndrome
- Hye Won Park, Joo Hoon Lee, Young Seo Park
- Clin Exp Pediatr. 2007;50(12):1231-1240. Published online December 15, 2007
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Purpose : Bartter syndrome is a renal tubular defect in electrolyte transport characterized by hypokalemia, metabolic alkalosis and other clinical signs and symptoms. The aims of this study were to analyze the clinical manifestations and the short- and long-term outcomes of Bartter syndrome. Methods : We retrospectively reviewed clinical history, laboratory finding of blood and urine, renal ultrasonography, and hearing... -
- Clinical, endocrinological and radiological courses in patients who was initially diagnosed as idiopathic central diabetes insipidus
- Seung Joon Chung, Seong Yong Lee, Choong Ho Shin, Sei Won Yang
- Clin Exp Pediatr. 2007;50(11):1110-1115. Published online November 15, 2007
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Purpose : Idiopathic central diabetes insipidus (CDI) is defined in CDI patients without definite etiology. Some patients initially diagnosed as idiopathic CDI progressed to organic causes. We reviewed clinical, endocrinological, and radiological courses of 20 patients who was initially diagnosed as idiopathic CDI, to assess the predicting factors for progression to brain tumors. Methods : We reviewed the medical data and... -
- Clinical significance of serum vascular endothelial growth factor in Kawasaki disease
- Ho Seok Lee, Sin Weon Yun, Young Soo Jung, Soo Ahn Chae, In Seok Lim, Dong Keun Lee, Eung Sang Choi, Byung Hoon Yoo, Mi Kyung Lee
- Clin Exp Pediatr. 2007;50(10):995-1004. Published online October 15, 2007
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Purpose : Kawasaki disease is a systemic vasculitis, leading cause of pediatric acquired heart disease. Vascular endothelial growth factor (VEGF) has functions as vascular permeability factor, plays an important role in coronary artery lesion (CAL). We studied the clinical significance of serum VEGF in Kawasaki disease. Methods : Kawasaki group was 49 patients, and control group was 15 patients. Diagnosis followed... -
- Growth promoting effect of combined gonadotropin releasing hormone analogue and growth hormone therapy in early pubertal girls with predicted low adult heights
- Eun-Jeong Hong, Heon-Seok Han
- Clin Exp Pediatr. 2007;50(7):678-685. Published online July 15, 2007
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Purpose : Recent reports pointed out that gonadotropin releasing hormone analogue (GnRHa) therapy alone is not so promising for improving adult height in precocious puberty. So, that we studied the growth promoting effect of combined therapy with GnRHa and growth hormone (GH) in early pubertal girls. Methods : Twenty three early pubertal girls (9.73?.59 yr) with predicted adult heights (PAH) below... -
- Growth promoting effect of short-term gonadotropin releasing hormone agonist with or without growth hormone in girls with early puberty
- Eun-Ju Lee, Heon-Seok Han
- Clin Exp Pediatr. 2007;50(2):198-204. Published online February 15, 2007
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Purpose : The hope that arresting pubertal developement might increase final adult height has led to an attempt to use GnRH agonist (GnRHa) in children with early puberty and poor growth prognosis. We investigated the growth-promoting effect of GnRH agonists with or without growth hormone (GH) in girls with early puberty and decreased predicted adult height (PAH). Methods : Thirty five... -
- Comparison of growth and neuropsychological function after treatment for hematologic and oncologic diseases in monozygotic twins
- Gi Hwan Kim, Hoon Kook, Hee Jo Baek, Dong Kyun Han, Eun Song Song, Young Kook Jo, Ic Sun Choi, Young Ok Kim, Chan Jong Kim, Young Jong Woo, Soo Jin Yang
- Clin Exp Pediatr. 2007;50(2):182-189. Published online February 15, 2007
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Purpose : The primary purpose of this study was to evaluate the growth and neuropsychologic function following treatments for pediatric hematologic and oncologic diseases. Healthy monozygotic twins served as ideal controls for comparison to exclude possible confounding factors. Methods : Seven children treated with various hematologic and oncologic diseases were included in the study: acute lymphoblastic leukemia (ALL; n=2), Diamond-Blackfan anemia... -
- Factors affecting the final adult height in survivors of childhood brain tumors
- Kyong-Ah Yun, Young Ah Lee, Choong Ho Shin, Sei Won Yang, Hee Young Shin, Hyo Seop Ahn, Il Han Kim
- Clin Exp Pediatr. 2007;50(1):65-73. Published online January 15, 2007
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Purpose : Short stature is an important complication that impairs the quality of life in survivors of childhood brain tumors. We studied their final adult height (FAH) to evaluate risk factors for short stature. Methods : We reviewed the medical data of 95 survivors of childhood brain tumors (64 males and 31 females) who had been followed up from 1982 to... -
- Review Article
- Adolescent nutrition and growth
- Sanghee Park
- Clin Exp Pediatr. 2006;49(12):1263-1266. Published online December 15, 2006
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- Original Article
- The influence of some intrauterine growth variables on neonatal blood pressure
- Jungwon Min, Eun Ae Park, Kyoungae Kong, Bohyun Park, Juhee Hong, Young Ju Kim, Hwayoung Lee, EunHee Ha, Hyesook Park
- Clin Exp Pediatr. 2006;49(9):966-971. Published online September 15, 2006
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Purpose : ‘Programming’ describes the process that stimulus at a critical period of development has lifelong effects. The fact that low birth weight links to the risk of elevated blood pressures in adult life is well known. This study aims to examine whether this link is evident in the newborn by investigating the relationship of the intrauterine growth indices and... -
- Review Article
- Current use of growth hormone in children
- Choong Ho Shin
- Clin Exp Pediatr. 2006;49(7):703-709. Published online July 15, 2006
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Since the advent of growth hormone(GH), children with a wide variety of growth disorders have received GH treatment. In GH deficiency(GHD), Turner syndrome, chronic renal failure, children born small for gestational age, Prader-Willi syndrome, and idiopathic short stature, the therapeutic effects and safety profile of GH are reviewed. GH therapy has been clearly shown to improve height velocity and final... -
- Original Article
- Effects of growth hormone treatment on glucose metabolism in idiopathic short stature
- Seung Yeon Kwon, Duk-Hee Kim, Ho-Seong Kim
- Clin Exp Pediatr. 2006;49(6):665-671. Published online June 15, 2006
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Purpose : To study the effects of growth hormone(GH) treatment on glucose metabolism and insulin resistance in children with idiopathic short stature(ISS). Methods : Glucose and insulin concentrations were measured during oral glucose tolerance test (OGTT) before and after GH treatment(0.6-0.7 IU/kg/week) in 20 patients with ISS. Insulin resistance was assessed by homeostasis model assessment(HOMA). Results : During OGTT, the mean... -
- Effect of GnRH analogue on predicted adult height in girls with early puberty
- Byung-Hoon Ahn, Heon-Seok Han
- Clin Exp Pediatr. 2006;49(5):552-557. Published online May 15, 2006
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Purpose : The recent results observed in precocious puberty and the hope that interrupting puberty might increase adult height have led to an attempt to use GnRH agonist(GnRHa) in children with premature puberty and a poor growth prognosis. We aimed to analyze the growth promoting effect of GnRHa in girls with early puberty and low predicted adult height(PAH). Methods : Thirty... -
- Effects of NG-monomethyl-L-arginine and L-arginine on cerebral hemodynamics and energy metabolism during reoxygenation-reperfusion after cerebral hypoxia-ischemia in newborn piglets
- Sun Young Ko, Saem Kang, Yun Sil Chang, Eun Ae Park, Won Soon Park
- Clin Exp Pediatr. 2006;49(3):317-325. Published online March 15, 2006
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Purpose : This study was carried out to elucidate the effects of nitric oxide synthase(NOS) inhibitor, NG-monomethyl-L-arginine(L-NMMA) and nitric oxide precursor, L-arginine(L-Arg) on cerebral hemodynamics and energy metabolism during reoxygenation-reperfusion(RR) after hypoxia- ischemia(HI) in newborn piglets. Methods : Twenty-eight newborn piglets were divided into 4 groups; Sham normal control(NC), experimental control(EC), L-NMMA(HI & RR with L-NMMA), and L-Arg(HI & RR... -
- The effect of growth hormone treatment in short children born small for their gestational ages
- Joo Hee Seo, Duk Hee Kim
- Clin Exp Pediatr. 2006;49(3):312-316. Published online March 15, 2006
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Purpose : Growth hormone(GH) has been recognized as an effective treatment for short children born small for their gestational ages(SGA), and nowadays it has been widely used for the treatment of short children born SGA. The aim of this study is to assess the efficacy of GH treatment for the children born SGA. Methods : The study population was made of... -
- The comparison of predicted adult height change and height gain after gonadotropin-releasing hormone agonist and combined growth hormone treatment in girls with idiopathic central precocious puberty
- Ji-Young Seo, In-Suk Yoon, Choong-Ho Shin, Sei-Won Yang
- Clin Exp Pediatr. 2006;49(3):305-311. Published online March 15, 2006
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Purpose : GnRH analogues(GnRHa) are used to treat central precocious puberty(CPP). However, in some patients, the GV decrease is so remarkable that it impairs predicted adult height(PAH); and there fore, the addition of growth hormone(GH) is suggested. We analysed the growth changes during two years and final adult height(FAH) in girls with idiopathic CPP treated with combined therapy, compared with... -
- Asthma predictive index in children with recurrent wheezing
- Joo Young Jang, Hyo Bin Kim, So Yeon Lee, Ja Hyung Kim, Bong Seong Ki, Hee Jung Seo, Soo-Jong Hong
- Clin Exp Pediatr. 2006;49(3):298-304. Published online March 15, 2006
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Purpose : We compared the asthma predictive index(API) and the modified asthma predictive index (mAPI) of the Tuscon Children's Respiratory Study Group in Korean children with recurrent wheezing. We investigated the atopic profiles and presence of allergen sensitization of each risk group, and ascertained the significant clinical risk factors. Methods : Two hundred and sixty two children, who visited for recurrent... -
- Endocrine dysfunction and growth in children with medulloblastoma
- In Suk Yoon, Ji Young Seo, Choong Ho Shin, Il Han Kim, Hee Young Shin, Sei Won Yang, Hyo Seop Ahn
- Clin Exp Pediatr. 2006;49(3):292-297. Published online March 15, 2006
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Purpose : In medulloblastoma, craniospinal radiation therapy combined with chemotherapy improves the prognosis of tumors but results in significant endocrine morbidities. We studied the endocrine morbidity, especially growth pattern changes. Methods : The medical records of 37 patients with medulloblastoma were reviewed retrospectively for evaluation of endocrine function and growth. We performed the growth hormone stimulation test in 16 patients whose... -
- Catch-up growth and development of very low birth weight infants
- Tae Ho Ma, Kyung Ah Kim, Sun Young Ko, Yeon Kyung Lee, Son Moon Shin
- Clin Exp Pediatr. 2006;49(1):29-33. Published online January 15, 2006
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Purpose : The aim of this study was to analyze the results and contributing factors of catch-up growth in very low birth weight infants(VLBWI) at the corrected age of 2 years. In addition, we looked for a relationship between the catch-up growth and the development by the bayley scales of infant development II(BSID II). Methods : A retrospective analysis by... -
- Growth Patterns of Breast Fed and Formula Fed Infants
- Ju Young Kwak, Jun Young Park, He Jin Lee, Hi Jin Jung, Sang Hi Son, Soo Jin Jung
- Clin Exp Pediatr. 2005;48(10):1055-1060. Published online October 15, 2005
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Purpose : The purpose of this study is to compare the growth pattern of breast fed and formula fed infants in the first 1 year of life. Methods : Anthropometric data(weight, length, head circumference) of at birth, 1, 3, 6, 9 and 12 months were collected by chart review and characteristics of subjects were collected by questionnaires. Among 358 infants,... -
- Inhibition of Vascular Endothelial Growth Factor-induced Endothelial Cell Differentiation by Intravenous Immunoglobulin and Methylprednisolone
- Hyoun Ah Choi, Kyung Hwa Ha, Jong Seo Yoon, Yoon Lee, Joon Sung Lee, Ji Whan Han
- Clin Exp Pediatr. 2005;48(8):886-893. Published online August 15, 2005
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Purpose : Kawasaki disease is the most common cause of systemic vasculitis in children less than 5 years of age. Recent immunohistochemistry findings suggest that many vascular growth factors play a role in the formation of the coronary artery lesions. Active remodeling of the coronary artery lesions in Kawasaki disease continues in the form of intimal proliferation and neoangiogenesis for... -
- Effects of Growth Hormone Therapy in Children with Idiopathic Short Stature
- Kyong A Lee, Heon Seok Han
- Clin Exp Pediatr. 2005;48(8):865-870. Published online August 15, 2005
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Purpose : The use of growth hormone(GH) to promote growth in normal short children without classical GH deficiency is controversial. Numerous foreign studies have shown the effects of GH therapy in children with idiopathic short stature(ISS) whereas few has been interested in Korea. Therefore, this study is designed to investigate the effects of GH therapy on ISS by observing correlations... -
- Expression of Nerve Growth Factor during Urinary Bladder Development
- Kyoung Eun Lee, Chang Hee Hong, Hee Jung Kang, Dug Ha Kim
- Clin Exp Pediatr. 2005;48(4):411-415. Published online April 15, 2005
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Purpose : This study was performed to determine the developmental expression pattern of nerve growth factor(NGF) in the urine of healthy children. It was hypothesized that NGF may contribute to the development of the spinobulbospinal micturition reflex that represents the adult micturition pattern. Methods : Voided urine was collected in 60 healthy children during the first 5 years of life(0-1 month,... -
- Evaluation of Serum Insulin-Like Growth Factor(IGF)-I, Insulin-Like Growth Factor Binding Protein(IGFBP)-2 and IGFBP-3 Levels in Healthy Korean Children
- Gi Hoon Yang, Hye Lim Jung, Deok Soo Kim, Jae Won Shim, Jung Yeon Shim, Moon Soo Park
- Clin Exp Pediatr. 2005;48(3):298-305. Published online March 15, 2005
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Purpose : We performed this study to evaluate the mean serum levels of insulin-like growth factor (IGF)-I, insulin-like growth factor binding protein(IGFBP)-2 and IGFBP-3 in healthy Korean children according to age and sex. Methods : Ninety two healthy children, consisting of 42 boys and 50 girls, were classified into five groups according to age : neonate; infancy; early childhood; late childhood;... -
- Factors Affecting Final Adult Height in Patients with Turner Syndrome
- Jae Hyun Kim, Sung Soo Lee, Su Young Hong, Hye Rim Chung, Choong Ho Shin, Sei Won Yang
- Clin Exp Pediatr. 2005;48(2):191-196. Published online February 15, 2005
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Purpose : Short stature is one of the characteristic features of Turner syndrome. We investigated the factors affecting final adult height(FAH) in patients with Turner syndrome. Methods : The study group was comprised of 60 patients who were diagnosed with Turner syndrome by chromosomal study and clinical phenotypes and attained FAH. Data were obtained from retrospective review of the medical records.... -
- The Effects of Intravenous Immunoglobulin(IVIG) and Methylprednisolone on the mRNAs Expressions of VEGF, VCAM-1 and IL-1β of Human Umbilical Vein Endothelial Cells(HUVEC) Stimulated by IL-1β
- Soh Yeon Kim, Sun Jeong Lim, Ji Whan Han, Kyung Yil Lee, Joon Sung Lee
- Clin Exp Pediatr. 2004;47(12):1325-1333. Published online December 15, 2004
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Purpose : Kawasaki disease(KD) manifests a systemic vasculitis of unknown etiology in young children. Vascular endothelial growth factor(VEGF), vascular cell adhesion molecule-1(VCAM-1) and interleukin-1 beta(IL-1β) may play important roles in the pathogenesis of KD. Intravenous immunoglobulin(IVIG) and methylprednisolone(MP) are therapeutically effective for KD, however, the precise mechanisms of the two drugs are still unknown. We investigated the therapeutic efficacy of... -
- Case Report
- A Case of Weaver Syndrome
- Jun Chul Byun, Chun Soo Kim, Sang Lak Lee, Tae Chan Kwon, Hee Jung Lee
- Clin Exp Pediatr. 2004;47(11):1216-1219. Published online November 15, 2004
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Weaver syndrome is a very rare overgrowth syndrome with accelerated skeletal maturation, unusual facies and clinodactyly. We experienced an extremely rare case of Weaver syndrome in Korea. The clinical manifestations were macrocephaly, unusal facies, simian crease, clinodactyly, decreased muscle tone, accelerated bone age and congenital heart diseases. We report this with a brief review of related literature. -
- Original Article
- Possible Neuroprotective Role of Exogenous Growth Hormone on Hypoxic-Ischemic Brain Injury in Neonatal Rats
- Young Pyo Chang, Mi Kyung Jung, Youn Hee Jee, Jae Ju Cho, Soon Bum Lee, Woo Sung Park, Jong-Wan Kim, Dong Hoon Shin
- Clin Exp Pediatr. 2004;47(11):1210-1215. Published online November 15, 2004
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Purpose : This study was performed to evaluate the possible neuroprotective effect of exogenous growth hormone on hypoxic-ischemic brain injury in neonatal rats. Methods : After ligation of the right common carotid artery, seven-day old Sprague-Dawley rats(n= 75) were exposed to 8% oxygen for two hours. In a growth hormone(GH)-treated group(n=25), each animal was subcutanously injected by GH(50 mg/kg, Grotrpin ,... -
- The Tumor Suppressor Function of PTEN/MMAC1 through the Regulation of IGFs and IGFBPs
- Ho Keun Yi, Dong Jin Hwang, Sun Young Kim, Dae Yeol Lee, Pyoung Han Hwang
- Clin Exp Pediatr. 2004;47(8):884-891. Published online August 15, 2004
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Purpose : PTEN/MMAC1, a novel tumor suppressor gene, is mutated in a variety of advanced and metastatic cancers. It acts as a phosphatase, and thereby, regulates the PI-3 kinase/Akt pathway. In this study, we examined to evaluate the new function of anti-tumor effects of PTEN/MMAC1 through the regulation of the IGFs-IGFBPs in gastric cancer cells. Methods : PTEN/MMAC1 was expressed in... -
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8.02023CiteScore94nd percentilePowered by
