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Original Article
Thyroid Hormone Concentrations in Preterm Infants
Sung Keun Moon, Jeong Nyun Kim, Mi Jung Park, Myung Jae Choi, Chrul Young Chung
Clin Exp Pediatr. 1998;41(10):1324-1328.   Published online October 15, 1998
Purpose : To establish reference ranges for thyroid hormone concentrations in premature infants, we measured T4 and thyroid stimulating hormone(TSH) concentrations and analyzed the relation to gestational age and birth weight. Methods : Serum T4 and TSH concentrations were measured by radioimmunoassay for 391 premature infants born in Sanggye Paik Hospital for two years and eight months. Results : Gestational age of...
The Study of Transplacental Transfer of Immunoglobulin G in Premature Infants
Sung Soo Moon, Yoon Ki Kang, Soo Chul Cho, Jung Soo Kim
Clin Exp Pediatr. 1998;41(6):747-753.   Published online June 15, 1998
Purpose : Premature infants have low serum immunoglobulin G(IgG) levels because IgG is transplacentally acquired, primarily after 32-34 weeks of gestational age. We studied the transplacental transfer of serum IgG in preterm infants. Methods : The IgG levels in the sera were measured by radial immunodiffusion method(Behring nephelometer, Germany). Results : There was a significant difference between IgG concentration and gestational age; the IgG concentration increased...
Effects of Patent Ductus Arteriosus on Right Ventricle in Premature Infants : by M-mode and Doppler Echocardiography
Eun Jeung Kim, Eun Sil Lee, Young Hwan Lee, Son Moon Shin, Jeong Ok Hah
Clin Exp Pediatr. 1998;41(6):734-740.   Published online June 15, 1998
Purpose : Patent ductus arteriosus, derived left to right shunt flows, elevate the pulmonary artery pressure in infants and children and may alter right ventricular afterload thereby right ventricular function. Therefore, we examined the effects of patent ductus arteriosus on the right ventricular systolic time interval in premature infants by non-invasive Doppler echocardiography. Methods : Tweleve premature infants with patent ductus arteriosus were studied...
Comparison of Continuous versus Intermittent Infusion of Indomethacin in PDA of Preterm Infants
Yun Kyoung Lee, Hee Seok Kim, Kyoung Ran Park, Chan Hu Park, June Dong Park, Beyong Il Kim, Woong Heum Kim, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1998;41(5):599-605.   Published online May 15, 1998
Purpose : Patent ductus arteriosus(PDA) of prematurity is very important disease to study because it causes many cases of perinatal morbidity and its incidence is now increasing. Nowadays indomethacin is the drug of choice for PDA closure, but its use has been limited due to its side effects. Therefore, we compared the effect and side effects of indomethacin according to...
Comparison of Continuous Versus Intermittent Infusion of Indomethacin in PDA of Preterm Infants
Yun Kyoung Lee, Hee Seok Kim, Kyoung Ran Park, Chan Hu Park, June Dong Park, Beyong Il Kim, Woong Heum Kim, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1998;41(4):464-470.   Published online April 15, 1998
Purpose : Patent ductus arteriosus(PDA) of prematurity is very important disease to study because it causes many cases of perinatal morbidity and its incidence is now increasing. Nowadays indomethacin is the drug of choice for PDA closure, but its use has been limited due to its side effects. Therefore, we compared the effect and side effects of indomethacin according to the infusion method, continuous...
Influence of Phototherapy on Incidence of Patent Ductus Arteriosus in Very Low Birth W eight Infants
Hee Seok Kim, Ee Kyung Kim, Yun Kyoung Lee, Hee Eun Lee, Chan Hwu Park, Kyung Ran Park, Jun Dong Park, Beyong Il Kim, Woong Heum Kim, Jung-Hwan Choi, Yong Su Yun, Chong Ku Yun, Jeong Mi Lee
Clin Exp Pediatr. 1997;40(10):1410-1418.   Published online October 15, 1997
Purpose : Patent ductus arteriosus(PDA) is a common disease in very low birth weight infants(VLBWI). Hemodynamically significant PDA increases the morbidity and mortality of premature infants. Based on experimental model, light inhibits the constriction of immature piglet' s ductal rings. No specific mechanism adequately explains the effect of light on the relaxation of PDA. Several hypotheses, including activation of photosensitive metabolites, alterations in receptors, or...
Visual Evoked Potentials in Healthy Preterm Infants
Young Kook Kim, Young Hwan Kim, Young Sook Hong
Clin Exp Pediatr. 1997;40(9):1219-1226.   Published online September 15, 1997
Purpose : The visual evoked potentials(VEPs) offer a window both on visual system function and on cerebral or neurologic function. The study was performed to evaluate the maturation of VEP in preterm infants and to present a guide to detect high risk neonates who can develop neurodevelopmental abnormalities. Methods : The VEPs were recorded in response to binocular stimulus with light-emitting diode goggles. VEP recordings...
Somatosensory Evoked Potential of Median Nerve in Preterm Infants
Young Hwan Kim, Kee Hwan Yoo, Young Sook Hong
Clin Exp Pediatr. 1997;40(6):801-808.   Published online June 15, 1997
Purpose : The purpose of this study was to standardize the somatosensory evoked potential(SEP) latency and amplitude of healthy preterm infants according to the postconceptional age. Methods : The median nerve SEPs were recorded in 30 healthy preterm infants who were followed up until 6 months and were neurodevelopmentally normal. Results : The mean peak latency and interpeak amplitude were following : P0=20.89±6.09(msec), N1=26.32±5.18, P1=31.16±6.59, N2=36.52±7.22...
Plasma Fibronectin Concentration in the Premature,Fullterm Neonates and Infants
Hyun Joo Lee, Kyung Hyo Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1997;40(4):473-479.   Published online April 15, 1997
Purpose : Plasma fibronectin has important role in the inflammatory response as non-specific opsonin and host defense. Plasma fibronectin concentration is different according to age and presence of infection. We performed this study to evalulate plasma fibronectin concentration in the healthy preterm, term neonates and infants and how that correlate with gestational age and birth weight and increased CRP concentration....
Doppler Analysis of Postprandial Intestinal Blood Flow in Healthy Preterm Infants
Yu In Park, Young Kook Kim, Young Sook Hong
Clin Exp Pediatr. 1996;39(6):780-787.   Published online June 15, 1996
Purpose : The newborn period is a time of rapid physiological change in the gastrointestinal tract, when adaptation from a state of parenteral nutrition to the demands of enteral feeding take place. little is known about the intestinal vascular responses that accompany intestinal adaptive changes, although there is much speculation about the relationship between entreral feeding, alterations in gut perfusion,...
Growth and Neurodevelopmental Outcome on Very Low Birth Weight Infants During 2 Years
Eun Suk Kim, Jong Uk Kim, Oh Kyung Lee, Wan Soeb Kim
Clin Exp Pediatr. 1996;39(5):641-651.   Published online May 15, 1996
Purpose : By rapid development of neonatal intensive care from 1960, we are able to expect the long survival of the very low birth weight infants. But, there were high risk of poor growth, neurodevelopmental delay, deafness, and blindness in very low birth weight infants. So, it is important to follow-up after discharge. We try to compare normal term infants with...
Surfactant Protein SP-A, B, and C: Purification and Biochemical Characterization
Chong-Woo Bae, Yong-Mook Choi, Joo Hyun Kang, Kil Lyong Kim, Kyung Soo Hahn
Clin Exp Pediatr. 1996;39(2):218-229.   Published online February 15, 1996
Purpose : Several kinds of exogenous pulmonary surfactants (SF), either synthetic or animalderived, are being used for the replacement therapy in respiratory distress syndrome (RDS) of newborn, especially in premature infants, and improved the neonatal mortality and morbidity. Because synthetic preparations are lack of surfactant protein (SP) and animal-derived preparations cause immunogenecity of heterogenous SP, there have been great necessity for the development of next...
Case Report
Two Cases of Systemic Candidiasis in Premature Infants
Dae Kyun Kim, Woo Chul Suh, Eun Gyeoung Jung, Eun Seok Yang, Sang-Kee Park
Clin Exp Pediatr. 1995;38(11):1558-1564.   Published online November 15, 1995
Reports of systemic candidiasis in neonates have been noted recently with its major advances in neonatal care permitting the frequent survival of low birth weight infant. Factors influencing the development of systemic candidiasis include prematurity, very low birth weight, the presence of intravascular catheter, the use of hyperalimentation, prolonged broad spectrum antimicrobial therapy and prolonged endotracheal intubation. We experienced two cases...
Original Article
Riboflavin Status of Normal Newborn Infants and the Changes of Riboflavin During Phototherapy in Hyperbilirubinemic Newborn Newborn Infants
Eun Ae Park, Gyoung Hee Kim
Clin Exp Pediatr. 1995;38(9):1185-1192.   Published online September 15, 1995
Purpose : Riboflavin is the most important water soluble vitamin in infant nutrition. Riboflavin is converts to flavin mononucleotide (FMN), Flavin adenine dinucleotide(FAD) and then, participiates in the metabolism of energy, protein cellular oxidation-reduction reactions as a cofactor of reactions. Also riboflavin, a light sensitive vitamin, has a maximum absorption spectrum at a wave length similar to that at which...
Trend of Maternal Measles Antibody in Korean Infants before 10 Months of Age
Phil-Soo Oh, Sung Hee Oh
Clin Exp Pediatr. 1995;38(5):619-624.   Published online May 15, 1995
Purpose : The measles epidemic occurrence has not well been controlled in Korea. Vaccin- ation schedule for measles in Korea has been modified in several occasions with insufficient da ta base. The most recent recommendation is to immunize at 9 months of age with measles va-ccine(at 6 months of age during epidemics) and reimmunize at 15 months of age with...
Clinical Studies of Metabolic Bone Disease of Prematurity
Seung-Yeon Suh, Eun-Kyung Lee, Ran Namgung, Hae-Jung Joo, Min-Soo Park, Kook-In Park, Chul Lee, Dong-Gwan Han, Meung-Jun Kim, Jin-Suk Suh
Clin Exp Pediatr. 1995;38(2):159-169.   Published online February 15, 1995
Purpose : Preterm formula used in Korea, theoretically does not supply the recommended mineral intake for optimal bone metabolism in very low birth weight infants(Formula 500-700 mg Ca/L, 300~370mg P/L, and 440IU of vitamin D/L). The purpose of this study is to identify th e possible etiologic factors and clinical course of rickets in these infants. Methods : We recently identified...
Clinical and Ultrasonographic Study on Prenatal Brain Damage in Newborn Infants
Kook In Park, Dong Gwan Han, Ran Namgung, Chul Lee
Clin Exp Pediatr. 1994;37(10):1364-1375.   Published online October 15, 1994
To determine the incidence of prenatal brain damage, and evaluate the clinical and neurosonographical characteristics, we prospectively examined 508 newborn infants with intracranial ultrasound within the first day of life who admitted to the NICU of Severance Hospital from June 1990 to January 1992 and reviewed maternal or neonatal medical records. We found 12 cases(2.4%) of fetal brain...
Meta-analysis of Impact of Neonatal Intensive Care on Neurodevelomental Outcome of Very Low Birth Weight Infants
Beyong Il Kim, Jung-Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1994;37(7):937-945.   Published online July 15, 1994
We analyzed neurodevelopmental outcome data of 36 selected studies. Data of individual studies were pooled by birth weight group: <800g, <1,000g, <1,500g and by time period of birth year: Period I(pre-intensive care era), 1960-67:Period II(beginning period of intensive care), 1968-76:and Period III(established period of intensive care), 1977-87. In all weight groups, survival and intact outcome rates based on live birth have...
Case Report
Two Cases of Toxic Shock Syndrome (TSS) in Infants
Jin Kil Park, Hong Ju Choi, Hee Tag Im, Jae Sam Kim, Hyo Kyung Shin, Chul Ho Koo
Clin Exp Pediatr. 1994;37(6):861-871.   Published online June 15, 1994
Much has been learned of the pathogenesis and pathophysiology of the toxic shock syndrome (TSS) sinde the initial description in 1978 by Dr. James K, Todd. The clinical illness in defined by the criteria listed in the case definition formulated for epidemiologic studies. With the advent of widespread recognition of TSS, there have been numerous published reports describing the clinical...
Original Article
Intractranial Hemorrhage in Full-Term Neonates by Ultrasonography
Chang Gyu Lim, Joon Soo Park, Woo Ryong Lee, Jae Ock Park, Sang Mann Shin, Sang Jhoo Lee
Clin Exp Pediatr. 1993;36(11):1570-1577.   Published online November 15, 1993
Intracranial hemorrhage is the most common neuropathologic finding in premature infants. But in full-term infants, It is less common and rarely causes death. We found out intracranial hemorrhages in 21 full-term neonates by real-time neurosonography and concluded as followings. 1) Among 21 neonates, 17 infants were male and 4 infants were female. 2) In 11(52.3%) infants the hemorrhage was detected within 7...
Comparison between Preterm and Fullterm infants in Neonatal Sepsis
Sung Hee Kim, Kum Hee Hur, Hee Sup Kim, Myoung Jae Chey, Kil Hyoun Kim, Hak Soo Lee
Clin Exp Pediatr. 1993;36(11):1542-1554.   Published online November 15, 1993
We retrospectively evaluated datas on 61 cases of neonatal sepsis confirmed by clinical symptoms and blood cultures at the NICU of Gil General Hospital From Mar. 1989, to Reb. 1992. The result obtained were as follows : 1) The mean gestational age was 32.7±2.6 weeks in preterm infants, and 39±1.5weeks on term infants. The mean birth weight was 1,701.4±422.4g in preterm infants,...
Clinical Observation for Low Birth Weight Infants
Hye Jin Lee, Soon Wan Kwon, Soon Ok Byun, Ji Sub Oh
Clin Exp Pediatr. 1993;36(7):928-935.   Published online July 15, 1993
Clinical observations were made on 338 low birth weight infants, who were delivered at Pusan Wallace Memorial Baptist Hospital, during the 3 year periods from 1989 to 1991. The results were as follows; 1) The incidence of LBWI was 5.6% and sex ratio was 1:1.09. Among them AGA was 62.7%. 2) Of all infants, 47.3% were in the birth weight range of 2251-2500...
Clinical Study on Infants of Diabetic Mothers
Eun Eui Kim, Min Jeong Kim, Yang Sook Choi, Son Sang Seo
Clin Exp Pediatr. 1993;36(3):347-355.   Published online March 15, 1993
A clinical observation was performed on the 80 cases of neonates born from diabetic mothers among the total of 34,936 neonates delivered at Il Sin Christian Hospital from January 1985 to December 1989. The results were as follows : 1) The incidence of infants of diabetic mothers was 0.23%, among whom gestational diabetic mothers were 63 cases(78.7%) and overt diabetic mothers...
Neurosonographic Diagnosis of Periventricular-Intaventricular Hemorrhage in Low Birth Weiht Infants
Hee Seok Koh, Dong Kyun Ryu, Young Tack Jang, Oh Kyung Lee, Jin Ok Choi
Clin Exp Pediatr. 1993;36(1):57-66.   Published online January 15, 1993
Periventricular-intraventricular hemorrhage (PV-IVH) is one of the most important neurologic lesion of the low birth weight infants. Serial neurosonographic examinations were performed in 113 low birth weight infants who were admitted to the neonatal internsive care unit of Presbyterian Medical Center from November 1, 1990 to July 31, 1991. The results were summarized as follows: 1) The incidence of PV-IVH in he study...
The Relationship Between Neonatal Hypoglycemia and Newborn Iron Status in Hypoglycemic Large-for-Gestational Age Infants
Myung Ja Yun, In Ho Song, Hye Lim Jung, Dong Hyuck Kum
Clin Exp Pediatr. 1992;35(12):1667-1673.   Published online December 15, 1992
We assessed the relationship between neonatal hypoglycemia and newborn iron status in hypoglycemic large-for-gestational age, euglycemic large for gestational age and euglycemic appropriate for gestational age infants that were admitted to the department of Pediatrics, Koryo General Hospital from July 1989 to June 1990. The results are as follows; 1) The incidence of large for gestational age infants was 3.3% (32...
Case Report
Transfusion-Acquired Cytomegalovirus Infections in Two Premature Infants
Dong Wook Kim, Kyung Un No, Mi Jung Kim, Soon Mee Park, Hee Sup Kim, Young Pyo Chang, Hoan Jong Lee, Jung-Hwan Choi, Chong Ku Yun, Je Geun Chi
Clin Exp Pediatr. 1992;35(8):1141-1147.   Published online August 15, 1992
Transfusion-acquired perinatal cytomegalovirus (CMV) infection can cause significant morbidity and mortality, particularly in premature infants with a birth wight of less than 1,500 gm. This recognizable syndrome consisted of deterioration of respiratory function, hepatosplenogaly, unusual gray pallor with disturbing septic appearance, lymphocytosis, thrombocytopenia and hemolytic anemia. We experienced transfusion-acquired CMV infections in 2 premature infants with a birth weight of...
An Autopsy Case of Infant of Diabetic Mother with d-Transposition of Great Arteries and Hypertrophic Cardiomyopathy
Kye Hwan Seol, Eui Kyeung Jung, Chang Sung Son, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1992;35(4):545-550.   Published online April 15, 1992
Generally, infants of diabetic mother(IDM) have various diseases and complications affecting multisystems resulting in high perinatal morbidity and mortality. It is well known that IDM have especially higher incidence of congenital anomalies including congenital heart disease(CH D). dTransposition of great arteries(d-TGA), ventricular septal defect and hypertrophic cardiomyopathy(HCM) form most of CHD occurring in IDM. Of these, HCM appears as a...
Original Article
Clinical and statistical observation for very low birth weight infants.
Sung Shin Park, Ji Hee Jung, Dong Hwan Lee, Sang Jhoo Lee
Clin Exp Pediatr. 1991;34(12):1629-1640.   Published online December 31, 1991
We made clinical and statistical observation of 90 very low birth weight infants who were admitted at Soonchunhyang university hospital during the 6 years period from January 1985 through December 1990. The result obtained were as follows: 1) The incidence of very low birth weight infant during 6 years period was 0.68%, and the mortality rate was 488/1000 very low birth weight infants. 2) There was no obvious...
Indomethacin therapy in premature infants with patent ductus arteriosus.
Dug Ha Kim, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1991;34(10):1381-1390.   Published online October 31, 1991
Patent ductus arteriosus (PDA) is a common disease that occurred in 20 〜 40 percent of premature infants. The incidence of PDA is inversely related to the gestational age and birth weight. Hemodynamically significant PDA increases the morbidity and mortality of premature infants. So, the management of PDA is one of the major problems in neonatal intensive care unit. Based on experimental animal studies,...
A case of neonatal systemic candidiasis.
Eun Ae Park, Gyoung Hee Kim
Clin Exp Pediatr. 1991;34(9):1286-1293.   Published online September 30, 1991
Systemic infection with Candida albicans in very premature infants is frequently fatal or associated with significant morbidity in survivors. Several common practices in newborn intensive care units, such as insertion of indwelling catheters, provision of parenteral nutrition, and prolonged administra- tion of broad-spectrum antibiotics or aminophylline, are associated with an increased risk of systemic disease. We have experienced a case of systemic candidiasis in 1/365...