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Original Article
Abnormalities of Hypothalamic-Pituitary MR Imaging and Pituitary Function in Patients with Growth Hormone Deficiency
Hun-Gy Kim, Han-Wook Yoo
Clin Exp Pediatr. 1998;41(6):791-798.   Published online June 15, 1998
Purpose : In this study, efforts have been made to evaluate the sella MRI in 14 patients with growth hormone deficiency to define more clearly the structural abnormalities of the hypothalamohypophyseal axis, examine frequency of these abnormalities, and determine whether a relationship exists between the sella MRI findings and types of endocrine dysfunction. Methods : Sella MRI was performed in 14 patients who were...
Case Report
Two Cases of Wolman's in Siblings
Joon Sung Kim, Tai Huyng Cho, Hoon Kook, Seung Hee Choi, Young Youn Choi, Chang Soo Park, Heoung Keun Kang, Dong Kyu Jin, Tai Ju Hwang
Clin Exp Pediatr. 1998;41(4):529-537.   Published online April 15, 1998
Wolman' disease is a rare autosomal recessive disorder in which a deficiency of lysosomal acid lipase leads to the accumulation of cholesteryl esters and trigycerides in most of the body tissues. Clinically, it is characterized by abdominal distention, hepatosplenomegaly, vomiting, intractable diarrgeam steatorrhea, malabsorption, inanitionm failure to thrive, and bilateral enlargement and calcification of the adrenal glands demonstrated by roentgenographic...
Original Article
Milk Feeding Methods and the Changes of Serum Lactate Level in Infants with Iron Deficiency Anemia
Du Young Choi, Jong Duck Kim
Clin Exp Pediatr. 1998;41(4):514-520.   Published online April 15, 1998
Purpose : Infants undergo critical and rapid stages of growth. Optimal nutrition during this period is therefore essential. Iron deficiency is especially impotant and common. The aim of this study was to determine the present status and problems of milk feeding methods in infants with iron deficiency anemia and, futhermore, to develop appropriate feeding guidelines for adequate iron nutrition. Latate is the end product...
Case Report
Two Cases of Factor XI Deficiency in Sisters
Yun-Kyeong Cho, Jae-Young Lim, Yang-Suk Jung, Chan-Hoo Park, Hyang-Ok Woo, Byung-Kiu Park, Hee-Shang Youn
Clin Exp Pediatr. 1998;41(3):401-404.   Published online March 15, 1998
We experienced two cases of factor XI deficiency in a 5 yearr 7 month-old girl, whose chief complaint was coke-colored gross hematuria, and her 9-year-old elder sister. The laboratory findings were prolonged aPTT and prominent deficiency of factor XI. The gross hematuria of the index case was identified due to acute poststreptococcal glomerulonephritis. So we report two cases of factor...
Original Article
The Relationships of Pretreatment IGF-I SDS, Delay in Bone Age and Response to Recombinant Human Growth Hormone(rhGH) Therapy in Children with Growth Hormone Deficiency
Seon-Young You, Ki-Joong Kim, Jeh-Hoon Shin, Jin-Nyoung Park, Hee-Jeong Ahn, Yong-Joo Kim
Clin Exp Pediatr. 1998;41(1):90-98.   Published online January 15, 1998
Purpose : To assess whether pretreatment IGF-I SDS and pretreatmental bone age are useful indicators in the response of rhGH therapy in children with GH deficiency(GHD), the relationship between pretreatment IGF-I SDS, delay in bone age and the growth response during the first year of rhGH treatment was analyzed. Methods : This study included 12 children with GHD. We measured IGF-I levels by RIA...
The Prevalence of A985G Mutation in Medium Chain Acyl-Coenzyme A Dehydrogenase(MCAD) Gene in Neonates Determined from Guthrie Card
Baeck Hee Lee, Hye Won Park, Moon Soo Park, Ho Jin Park, Yong Choi, Hae Il Cheong
Clin Exp Pediatr. 1997;40(12):1645-1650.   Published online December 15, 1997
Purpose : Medium chain acyl-CoA dehydrogenase(MCAD) deficiency is an autosomal recessive disoder of β oxidation of fatty acids and characterized by episodic hypoglycemia, vomiting, convulsion, encephalopathy, apnea, and sudden death related to fasting or infection resembling Reye syndrome or sudden infant death syndrome. In acute stage, mortality rate is very high and survivors have significant risk of developmental disability and chronic somatic illness. However,...
Long-term Growth Response to Growth Hormone Therapy in Children with Growth Hormone Deficiency
Byung Churl Lee
Clin Exp Pediatr. 1997;40(5):672-679.   Published online May 15, 1997
Purpose : The aim of this study was to evaluate the long-term growth response to growth hormone therapy in 18 children with naive growth hormone deficiency. Methods : The subjects of this study were aged 3-13.5 years and each patient continuously received GH(EutropinⓇ) 0.45-0.7IU/kg/week, intramuscularly or subcutaneously in 3-7 divided dose for up to 7 years. Standard auxologic assessment was carried...
Case Report
A Case of Lymphocytic Interstitial Pneumonia
Ho Young Lee, Hwang Min Kim, Mee Kyung Namgoong, Jong Soo Kim, Soon Hee Jung, Dong Jin Kim
Clin Exp Pediatr. 1997;40(4):572-577.   Published online April 15, 1997
Lymphoid interstitial pneumonia(LIP) is an uncommon process in childhood, and is characterized by interstitial accumulation of mature lymphocytes, plasma cells and reticuloendothelial cells. LIP is believed to have autoimmune or immunologic pathogenesis, because it is frequently associated with acquired immune deficiency syndrome, Epstein-Barr virus infection, common variable immunodeficiency. The patient described in this report had idiopathic thrombocytopenic purpura, Evans syndrome...
Erythrocyte Band 7 Integral Protein Defectin Congenital Hemolytic Anemia: Hereditary Stomatocytosis
Chang Seoup Sim, Sang Joo Han, Hong Jin Lee, Woo Ill Park, Kyung Ja Lee, So Young Chung, Sechan Woo, Eui Yul Choi
Clin Exp Pediatr. 1997;40(2):260-264.   Published online February 15, 1997
Hereditary stomatocytosis is a rare congenital hemolytic anemia, named after mouth shaped or stomatocytic erythrocyte morphology. In this report, we present a case of a hereditary stomatocytosis in a 1 month old boy. During the initial identification process, we overlooked the morphology of the RBC in peripheral blood smear and tentatively diagnosed it to be a hereditary spherocytosis case. In order to...
A Case of Nezelof's Syndrome
Hyeon Tae Kim, Nok Hong Kim, Eun Yeong Seol, Ki Hyun Chun, Kung Ho Lee, Mun Ki Cho, Kung Ran Choi
Clin Exp Pediatr. 1996;39(11):1620-1626.   Published online November 15, 1996
Nezelof's syndrome(combined immunodeficiency with immunoglobulin) is a hereditary primary immunodeficiency characterized by recurrent chronic pulmonary infections, oral and cutaneous candidiasis, failure to thrive, chronic diarrhea, skin infection, urinary tract infection, gram-negative sepsis, severe progressive varicella infection, lymphopenia, diminished lymphoid tissue, abnormal structure of the thymus, and presence of normal or increased levels of one or more of the major immunoglobulin classes, but with impaired antibody...
Original Article
The Characteristics of Insulin-like Growth Factor Binding Protein-3(IGFBP-3) in Serum; The Diagnostic Utility of IGFBP-3 in Growth Hormone Deficiency
Ki-Joong Kim, Jeh-Hoon Shin, Young-Ik Lee
Clin Exp Pediatr. 1996;39(11):1594-1599.   Published online November 15, 1996
Purpose : For diagnosis of growth hormone(GH) deficiency in short stature, peak growth hormone levels after pharmacologic stimulation are usually used. In this study, we measured serum IGFBP-3, which is a major binding protein in serum and is considered to be GH-IGF-I axis dependent, levels by radioimmuno assay(RIA) in sera from normal short stature(NSS) children, and patients with GH deficiency children to clarify the...
Case Report
Four Cases of Iron Deficiency Anemia with Helicobacter pylori Infection
Houng Soung, Cheol Ho Chang, Churl Young Chung
Clin Exp Pediatr. 1996;39(8):1173-1178.   Published online August 15, 1996
Helicobacter pylori has become apparent that this organism is an etiologic agent of gastrits and peptic ulcer disease in humans. We present four cases of iron deficiency anemia, not specific causes, in 3 males and 1 female patients with Helicobacter pylori infection, who were treated with antibiotics and iron supplemented therapy. Diagnosis was confirmed by endoscopic biopsies and hematologic findings. A brief review of related...
A Case of Combined Congenital Deficiency of Factor V and Factor VIII
Kue Chang Cho, Soo Kyung Lee, Il Kyung Kim, Ho Sung, Chang Hee Choi
Clin Exp Pediatr. 1996;39(8):1162-1167.   Published online August 15, 1996
Hemorrhagic disease of newborn by combined blood clotting factor deficiencies is very rare. Combined deficiency of factor V and factor VIII is the most common form among these cases, and inherited by autosomal recessive trait. Clinical findings are easy bruising, posttraumatic bleeding and bleeding after tooth extractions, and the main laboratory findings are prolonged partial thromboplastin time (PTT) and prothrombin time (PT) that are...
Original Article
The Concentration of Insulin Like Growth Factor-I(IGF-I) and IGF-Binding Protein-3 (IGFBP-3) in the Serum of Children with Growth Hormone Deficiency and the Alterations after Growth Hormone Treatment
Woo Yeong Chung, Dae-Yeol Lee
Clin Exp Pediatr. 1996;39(6):846-855.   Published online June 15, 1996
Purpose : The insulin like growth factors (IGFs) circulate complexed to IGF-binding proteins(IGFBPs). IGFBP-3 is the major circulating IGFBP and is found primarily as a 150 kDa complex which contains an acid labile subunit(ALS), IGFBP-3, and IGF-I or IGF-II and is considered to be growth hormone(GH) dependent. In this study, we measured serum IGF-I, IGFBP-3 and 150 kDa levels in sera of growth hormone...
Case Report
A Case of17α-Hydroxylase Deficiency
Yong Kyu Lee, Yun Jong Kang, Chan Young Pak, Soo Young Choi, Moon Soo Park
Clin Exp Pediatr. 1996;39(4):577-584.   Published online April 15, 1996
A 12-year-old girl with hypertension, hypokalemia, cystic ovaries and absence of secondary sexual development is presented. Hormonal study revealed very low levels of cortisol, testosterone, estrogen, and high levels of progesterone, deoxycorticosterone, corticosterone, FSH and ACTH. Following treatment with dexamethasone and estrogen, the levels of the latter group remarkably decreased. Serum potassium level and blood pressure also became normal. With...
Original Article
Immunologic Considerations in the Pathogenesis of Chronic and Recurrent Sinusitis in Children
Jun Ki Jung, Bok Yang Pyun, Sang Mann Shin, Sang Jhoo Lee
Clin Exp Pediatr. 1996;39(2):207-217.   Published online February 15, 1996
Purpose : Although the chronic sinusitis is one of the most common and troublesome respiratory diseases in children, the pathogenesis still remains unclear. It is suggested that many of the immunologic factors including allergic conditions may contribute the nasal inflammatory changes. This study was designed to evaluate and demonstrate the possible role of various immunologic factors on the pathogenesis of...
The Correlation between the Duration of Breast Feeding and Iron Deficiency Anemia(IDA)
Yee Ja Kang, Ha Sin Park, Hae Jin Choeh, Kyuchul Choeh
Clin Exp Pediatr. 1995;38(11):1453-1459.   Published online November 15, 1995
Purpose : Iron deficiency anemia(IDA) is the most common nutritional deficiency. in young infants. This study was designed to determine a correlation between the duration of breast feeding and the severity of IDA, and to determine the recommending start point of iron fortified diet. Methods : The correlation between duration of breast feeding, and severity of iron deficiency. and IDA was...
Relationship of Insulin-like Growth Factor-I with Pharmacologically Stimulated Growth Hormone secretion in Growth hormone Deficient Children
Phil-Soo Oh, Ki-Joong Kim, Young-Iee Yu, In-Joon Seol, Jeh-Hoon Shin
Clin Exp Pediatr. 1995;38(10):1394-1403.   Published online October 15, 1995
Purpose : At present, to determine growth hormone(GH) deficiency in short stature, many provocative tests using various pharmacologic agents such as clonodine, L-dopa, insulin should be done. These are not only complicated, but also misleading in some patients. And so, in search of a simple method of detecting GH deficiency that may replace the complicated stimulation test, we measured basal...
Iron Deficiency Anemia in Infants
Woon Ja Chung, Kue Sook Kim, Mi Kyung Kim, Shin Na Kim
Clin Exp Pediatr. 1995;38(9):1253-1261.   Published online September 15, 1995
Purpose : To study the incidence of iron deficiency anemia we conducted blood tests with questionnaire regrarding weaning status. We tried to figure out the relation between iron deficiency anemia and financial and educational levels of their parents. The purpose of this study is to emphasize the importance of screening for iron deficiency anemia at well baby clinic and educate mothers...
Diagnostic Significance of Urinary Growth Hormone Measurement in Patients with Growth Hormone Deficiency
No Hyun Kim, Woo Yeong Chung, Soon Yong Lee
Clin Exp Pediatr. 1995;38(8):1124-1131.   Published online August 15, 1995
Purpose : To investigate the diagnostic significance of urinary growth hormone measurement and compare with the urinary GH values in different methods of urine collection, this study was performed in patients with short stature. Methods : Measurement of urinary GH excretion was performed in 9 children with complete growth hormone deficiency (GCD), in 19 children with partial growth hormone deficiency (GPD)...
Case Report
Two Cases of Congenital TBG Deficiency
In Seong Jo, Ha Joo Choi, Young Ah Lee, Woo Gap Chung, Youn Bok Chang
Clin Exp Pediatr. 1995;38(5):697-701.   Published online May 15, 1995
We have experienced 4 and 5-week-old male neonates presented low T4 and normal TSH l-evel by filter paper mothod for neonatal screening, finally diagnosed typical TDG deficiency wit h TBG radioimmunoassay, paper electrophoresis, and autoradiography. Two neonates have ha d no specific complaints and lived well until now. Congenital TBG deficiency is an X chromosome linked inhcritant disorder characterized by l...
Original Article
Comparison of Oxygenation and Lung Damage of High Frequency Flow Interruption to Conventional Ventilation in Surfactant Deficient Rabbits
Chang Keun Kim, Churl Young Chung, Hye Jae Cho
Clin Exp Pediatr. 1995;38(5):591-601.   Published online May 15, 1995
Purpose : This study was performed kto evaluate the High frequency flow interruption(HFF I) can prevent the lung injury and achieve a bettre oxygenation than conventional ventilation(C V) in surfactant deficient lungs when associated with lung volume recruitment and maintenance, and the need of background intermittent mandatory ventilation(IMV) to prevent the progressive atelectasis during HFFI. Methods : Surfactant deficiency was produced...
Case Report
Two Cases of Tetrahydrobiopterin Deficiency
Jee Won Choi, Sei Won Yang, Hyung Ro Moon, Se Chin Cho
Clin Exp Pediatr. 1995;38(3):397-403.   Published online March 15, 1995
Tetrahydrobiopterin(BH4) deficiency is a rare type of hyperphenylalaninemia and usually leads to a progressive neurologic deterioration despite early dietary control of blood phenylalanine concentration. We experienced two cases of BH4 deficiency in brother and sister, confirmed by biochemical study of blood and urine. They had suffered from a progressive neurologic illness such as mental retardation, severe hypotonia, seizure, and athetotic movements...
Original Article
A Study on Nutritional Status of Iron and Lipids in Infants
Kwang-Hea Choi, Son Moon Shin, Kee-Hwa Oh, Jung Sook Seo, Kwang-Soo Kim, Yung-Sun Choi
Clin Exp Pediatr. 1995;38(3):297-305.   Published online March 15, 1995
Purpose : This study was conducted to get baseline data to establish a guideline for the infant nutrition by observing the feeding practice and nutritional intake during infancy and evaluationg the nutritional status of iron and lipids at 12-month-old infants. Methods : This survery was cnducted from July to November, 1992. Subjects were healthy infants who were brought to Yeungnam University...
Case Report
Longterm Follow Up of A Case of Eosinophilic Gastroenteritis
So Young Lee, Jeong Kee Seo
Clin Exp Pediatr. 1995;38(1):104-109.   Published online January 15, 1995
Eosinophilic gastroenteritis(EG) is a rare disease characterised histologically by eosinophilic infiltration of the gut wall. The clinical features depend on which layer and location are involved. Patients may be divided into three clinical groups as predominantly mucosal, muscle layer, or subserosal disease based on the histological site of eosinophilic infiltration of the bowel wall, although there is lften considerable overlap....
Original Article
Characteristics of Insulin-Like Growth Factor I in Serum; Pattern of Insulin-Like Growth Factor Binding Protein (Large Complex) in Short Stature Patients with Complete Growth Hormone Deficiency
Jin Nyoung Park, Byung Deok Seo, Jeh Hoon Shin, Soo Ji Moon, Sung Yeoul Chang
Clin Exp Pediatr. 1994;37(11):1548-1559.   Published online November 15, 1994
To elucidate the complex of insulin-like growth factor binding proteins (IGF-BPs) in short stature patients, we carried out a prospective study on three patients who were diagnosed as complete GH deficiency at the department of pediatrics form July 1992 to June 1993. The results were summarized as follows: 1) Two circulating IGFs complexed to specific binding protein existed in normal serum. Binding...
Case Report
Congenital Adrenal Hyperplasia with 21-hydroxylase Deficiencies in Twins
Young Don Kim, Jeong Hwa Choi, Jae Hong Park, Hee Ju Park, Seong Suk Jeon
Clin Exp Pediatr. 1994;37(10):1469-1473.   Published online October 15, 1994
Congenital adrenal hperplasia is inherited disorder of adrenal steroidogenesis. 21-hydroxylase deficiency is the most commone enzymatic defect and is divided into classic and late-onset or nonclassic forms. Both classic and non-classic 21-hydroxylase deficiencies are inherited in a recessive manner as allelic variants. But it is rare that happened in twin infants. Chief complaints of affected twins in our case were ambiguous...
Original Article
Diagnostic Significance of Red Cell Indices in Non-anemic Iron Deficiency and Iron Deficiency Anemia: Reevaluation with ROC Curve
Hwang Min Kim, Won Kyu Choi, Jae Seung Yang, Jong Soo Kim
Clin Exp Pediatr. 1994;37(1):33-39.   Published online January 15, 1994
To validate the diagnostic significance of red cell indices in non-anemic iron deficiency and iron deficiency anemia, complete blood count, serum iron, total iron binding capacity, and serum ferritin were measured in 208 middle school girls between 13 and 15 years age. We used Reciever Operating Characteristic (ROC) curve to compare the diagnostic significances of various red cell indices (MCV,...
The Impact of Large Amount Whole Cow's Milk Intake on Iron Status in Early Childhood
Sung Yoon Byun, Mi Ran Park, In Sang Jeon
Clin Exp Pediatr. 1993;36(7):968-974.   Published online July 15, 1993
To determine the impact of intake large amount whole cow's milk (WCM) on iron status during early childhood(18~36 months), selected indices of complete blood count (CBC) and iron status were compared between the WCM large amount intake group (n=20) and small amount intake group (n=20). WCM large amount intake children's mean hemoglobin and mean hematocrit were 9.6¡¾1.7g/dl and 30.8¡¾4.5% respectively. These...
Clinical Significance of Urinary Growth Hormone Measurement in patients with Growth Hormone Deficien
Ho Seong Kim, Duk Hi Kim, Min-Seok Cheon
Clin Exp Pediatr. 1993;36(4):478-484.   Published online April 15, 1993
Urinary growth hormone (GH) excretion was quantitated in 12-hr overniaght urine collections obtained from 13 children with complete growth hormone deficiency(CGHD), 6 children with partial growth hormone deficiency(PGHD), 5 children with short stature and normal GH provocation tests(NSC), and 5 normal control children (NC) to investigate whether the measurement of urinary GH can clearly separate the PGHD and CGHD groups...
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