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Review article
Recent advances in food allergen immunotherapy
You Hoon Jeon, Edwin H. Kim
Food allergies can pose significant risks and profoundly impact the quality of life of children and their families, making them a major public health concern. Allergen avoidance has been the traditional mainstay of treatment; however, recent research has focused on various approaches to food allergen immunotherapy. This review summarizes the recent advancements in oral, sublingual, and epicutaneous immunotherapies, highlighting their...
Review Article
Allergy
Practical issues of oral immunotherapy for egg or milk allergy
Sukyung Kim, Kangmo Ahn, Jihyun Kim
Clin Exp Pediatr. 2024;67(3):140-148.   Published online June 19, 2023
· Oral immunotherapy should be supervised by pediatricians with experience administering oral food challenge tests and managing allergic reactions.
· Food allergen intake is gradually increased and maintained for years.
· Patients may experience allergic reactions and psychological problems.
· Adjunctive therapies (biologics, antihistamines, and leukotriene receptor antagonists) may improve efficacy and safety.
· Contraindications include uncontrolled asthma, malignancy, active autoimmune disorders, and beta-blocker usage.
Skin and oral intervention for food allergy prevention based on the dual allergen exposure hypothesis
Kiwako Yamamoto-Hanada, Yukihiro Ohya
Early-onset atopic dermatitis increases the risk of food allergies, suggesting that transcutaneous sensitization may occur through inflamed skin. Regarding food allergy causation, the dual allergen exposure hypothesis proposes that oral-route allergen exposure leads to immune tolerance, whereas allergen exposure via the inflamed skin causes food allergy. This hypothesis implies that it is important to induce oral immune tolerance and prevent...
Original Article
Allergy
Clostridium difficile colonization and/or infection during infancy and the risk of childhood allergic diseases
Sun Hwa Lee, Yun Na Gong, Eell Ryoo
Clin Exp Pediatr. 2017;60(5):145-150.   Published online May 31, 2017
Purpose

The gut microbiota can influence several diseases through immune modulation; however, the exact role of microbes such as Clostridium difficileand the relationship between microbiota colonization and allergic diseases are not well known. This study aimed to determine the relationship between C. difficilecolonization and/or infection (CDCI) during infancy and allergic diseases during early childhood.

Methods

Infants 1–12 months of age presenting changes in...

Review Article
Allergy
IgE-mediated food allergies in children: prevalence, triggers, and management
Sooyoung Lee
Clin Exp Pediatr. 2017;60(4):99-105.   Published online April 25, 2017

Food allergy (FA) is a serious health problem, and severe FA such as food-induced anaphylaxis can often be life threatening. The incidence of FA has been increasing especially in children. They usually develop early in life and affect up to 10% of children. The 2 most common food allergens worldwide are milk and eggs, while the third one varies depending...

A practical view of immunotherapy for food allergy
Tae Won Song
Clin Exp Pediatr. 2016;59(2):47-53.   Published online February 29, 2016

Food allergy is common and sometimes life threatening for Korean children. The current standard treatment of allergen avoidance and self-injectable epinephrine does not change the natural course of food allergy. Recently, oral, sublingual, and epicutaneous immunotherapies have been studied for their effectiveness against food allergy. While various rates of desensitization (36% to 100%) and tolerance (28% to 75%) have been...

Food protein-induced proctocolitis: Is this allergic disorder a reality or a phantom in neonates?
Jin-Bok Hwang, Jeana Hong
Clin Exp Pediatr. 2013;56(12):514-518.   Published online December 20, 2013

The etiology of small and fresh rectal bleeding in neonates who are not sick is usually unknown; the only known cause is food protein-induced proctocolitis (FPIPC). It has been recently reported that FPIPC is a rare cause of rectal bleeding in newborns, and most cases have been proved to be due to idiopathic neonatal transient colitis. A recommended strategy for...

Food allergy
Youngshin Han, Jihyun Kim, Kangmo Ahn
Clin Exp Pediatr. 2012;55(5):153-158.   Published online May 21, 2012

Food allergy is an important public health problem affecting 5% of infants and children in Korea. Food allergy is defined as an immune response triggered by food proteins. Food allergy is highly associated with atopic dermatitis and is one of the most common triggers of potentially fatal anaphylaxis in the community. Sensitization to food allergens can occur in the gastrointestinal...

Oral food challenges in children
Hye Yung Yum, Hyeon Jong Yang, Kyung Won Kim, Tae Won Song, Woo Kyung Kim, Jung Hee Kim, Kang Mo Ahn, Hyun Hee Kim, Soo Young Lee, Bok Yang Pyun
Clin Exp Pediatr. 2011;54(1):6-10.   Published online January 31, 2011

Many patients assume that allergic reactions against foods are responsible for triggering or worsening their allergic symptoms. Therefore, it is important to identify patients who would benefit from an elimination diet, while avoiding unnecessary dietary restrictions. The diagnosis of food allergy depends on the thorough review of the patients's medical history, results of supplemented trials of dietary elimination, and in...

Original Article
Analysis and Evaluation of the Reliability of Medical Information on Food Allergies on the Internet
Young Bun Cho, Young Shin Yoon, Ji Yeon Chang, Sun Mi Kim, Kwi Sook Kim, Chang Hee Choi
Clin Exp Pediatr. 2004;47(8):868-872.   Published online August 15, 2004

Purpose: The information in the internet is increasing and the number of people using the Internet to obtain medical information is increasing rapidly too. But, compared to the amount of information, the quality of information is extremely variable. To assess the accuracy of medical information on the Internet, the quality of information about food allergies available on the internet examined. Methods:...
Clinical Lecture
Food Allergy
Soo-Young Lee
Clin Exp Pediatr. 2004;47(3):240-246.   Published online March 15, 2004
Food allergy is one of the clinical clusters due to food-induced allergic inflammation against dietary proteins which induced by IgE-mediated and/or non-IgE mediated mechanisms. Food allergic reactions are responsible for a variety of clinical symptoms involving the skin, gastrointestinal tract, and respiratory tract. Sometimes the life threatening anaphylactic reactions would be induced, especially by peanuts, tree nuts and buckwheat allergy....
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