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Case Report
A Case of Combined Congenital Deficiency of Factor V and Factor VIII
Kue Chang Cho, Soo Kyung Lee, Il Kyung Kim, Ho Sung, Chang Hee Choi
Clin Exp Pediatr. 1996;39(8):1162-1167.   Published online August 15, 1996
Hemorrhagic disease of newborn by combined blood clotting factor deficiencies is very rare. Combined deficiency of factor V and factor VIII is the most common form among these cases, and inherited by autosomal recessive trait. Clinical findings are easy bruising, posttraumatic bleeding and bleeding after tooth extractions, and the main laboratory findings are prolonged partial thromboplastin time (PTT) and prothrombin time (PT) that are...
Original Article
Vitamin K Dependent Hemorrhagic Disease of the Newborn and Infancy with Intracranial Hemorrhage.
Ji Eun Lee, Pal Dong Kim, Hong Dae Cha, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 1990;33(9):1209-1215.   Published online September 30, 1990
Eight cases of vitamin K dependent hemorrhagic disease of the newborn and infancy with intra- cranial hemorrhage were analysed clinically. Out of 8 cases, 3 cases developed the bleeding within 7 day of life and 5 cases after one month. Two cases had bleeding before initial feeding. Out of 6 cases who were fed before the onset of bleeding, 4 cases had breast feeding. Neurological...
Preventive Effect of Single Dose Vitamin K for the Late Hemorrhagic Disease of Infancy.
Young Youn Choi, Hwa Il Kwag, Byung Hee Kim, Tai Ju Hwang
Clin Exp Pediatr. 1990;33(5):606-614.   Published online May 31, 1990
To evaluate the preventive effect of single dose vitamin K for the late hemorrhagic disease of infancy, hepaplastin test was carried out in 15 breast-fed and 12 formula-fed babies. Vitamin Ki lmg was injected immediately after the birth intramuscularly and the test was performed the 1st (before vitamin k administration), 3rd, 7th, 28th days of life and the end of the 2nd and...
2 Cases of Intracranial Hemorrhae due to Late Hemorrhagic Disease of Infancy due to Vitamin K Deficiency.
Bong Hyune Chung, Hee Jung Seo, Young Hee You, Hyung Sook Lee
Clin Exp Pediatr. 1989;32(12):1726-1731.   Published online December 31, 1989
A clinical study was done on 2 cases under the diagnosis of late hemorrhagic disease of infancy due to Vitamin K dependent factor deficiency. The following results were obtained. The disorder occured most frequently during early infancy (40 days of age & 2 months of age) with male predominance (2 cases all are male). G-I tract, skin, CNS were the most common site...
6 Cases of Intracranial Hemorrhage due to late Late Hemorrhage Disease of Infancy.
Sang Ho Choi, Jae You Choi, Jee Sung Kim, Im Ju Kang
Clin Exp Pediatr. 1988;31(1):106-112.   Published online January 31, 1988
A bleeding syndrome in early infancy due to vitamin K deficiency has been reported sporadically from various parts of world. The syndrome has similarities to hemorrhagic disease of newborn. The main differences are that it is found in an older age group, the pathogenesis is unknown, and intracranial hemorrhage are frequent with a resultant high mortality rate. We have experienced 6 cases of spontaneous...
Late Hemorrhagic Disease of Infancy.
Kwang Wook Ahn, Chull Zoo Jung, Hyo Seop Ju, Seung Woo Moon
Clin Exp Pediatr. 1986;29(6):679-683.   Published online June 30, 1986
Late hemorrhagic disease of infant is a hemorrhagic disease due to prothrombin complex deficiency from 1 week to 1 year of age. It is hypothesized that the bleeding occurring may have resulted from the simultaneous occurrence of two or three of the following factors: (1) interference with the intestinal production of vit K as a result of Antibiotic Agents, (2)...
Case Report
Five Cases of Hemorrhagic Disease of Infancy.
Jung Sook Moon, Eun Hee Koh, Sang Man Shin, Sang Jhoo Lee
Clin Exp Pediatr. 1982;25(5):518-522.   Published online May 31, 1982
A hemorrhagic disease due to acquired prothrombin complex deficiency is presented in five infants from 3 weeks to 2 months of age. There are 2 cases of intracranial hemorrhage, 1 case of hemothorax, 2 cases of gastrointestinal bleeding, 1 case of epistaxis and 3 cases of petechia, purpura or bleeding from injection site. After the administration of vitamin K, bleeding...
Original Article
Late Hemorrhagic Disease of Infancy due to Vitamin K Dependent Factor Deficiency.
Kang Il Lee, Yong Soon Kim, Sang Bum Lee, Ja Hoon Koo
Clin Exp Pediatr. 1982;25(1):52-57.   Published online January 31, 1982
A clinical study was done on 9 children with 10 episodes, who were admitted to our pediatric ward under the diagnosis of late hemorrhagic disease of infancy due to vitamin K dependent factor deficiency. Study period was past 2 years, from September 1979 to May 1981. The following results were obtained. This disorder occurred most frequently during early infancy, with...
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