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Original Article
Gastroenterology
Evaluating the effects of probiotics in pediatrics with recurrent abdominal pain
Parisa Rahmani, Azin Ghouran-orimi, Farzaneh Motamed, Alireza Moradzadeh
Clin Exp Pediatr. 2020;63(12):485-490.   Published online July 21, 2020
Question: ecurrent abdominal pain (RAP) is a chief complaint among pediatrics and is associated with reduced quality of life, for both parent and child, and economic burden. Does probiotics reduce the frequency of RAP among children?
Finding: This study reported the effects of Lactobacillus reuteri probiotics among children with RAP as a result of multiple etiologies.
Meaning: The administration of probiotic supplements is significantly associated with pain relief among RAP children presented with functional abdominal pain, irritable bowel syndrome, and functional dyspepsia.
Case Report
Genetics and Metabolism
A rare case of Sjogren-Larsson syndrome with recurrent pneumonia and asthma
Azita Tavasoli, Shirin Sayyahfar, Babak Behnam
Clin Exp Pediatr. 2016;59(6):276-279.   Published online June 30, 2016

Sjogren-Larsson syndrome (SLS) is a rare autosomal recessive neurocutaneous disorder with worldwide incidence of 0.4 per 100,000 people. It is characterized by the triad of congenital ichthyosis, spastic diplegia or quadriplegia, and mental retardation. Herein we report a 2-year-old male child with SLS, asthma, and recurrent pneumonia. SLS was confirmed by a molecular genetics study that revealed a deletion mutation...

Review Article
Helicobacter pylori infection and abdominal pain in children
Jeong Kee Seo
Clin Exp Pediatr. 2006;49(2):136-143.   Published online February 15, 2006
The relationship between H. pylori(Hp) infection and recurrent abdominal pain(RAP) in children is not clear. Current data in the literature regarding a causal relationship between Hp infection and childhood RAP are conflicting. However, meta-analysis and most of the recently published studies have not supported an association between Hp infection and an increased prevalence of abdominal pain. Most published studies have...
New approach to chronic recurrent abdominal pain in children
Hye Ran Yang
Clin Exp Pediatr. 2006;49(2):129-135.   Published online February 15, 2006
Chronic recurrent abdominal pain is a common manifestation in children. Functional abdominal pain is the most common cause of chronic abdominal pain and can be diagnosed properly by the physician without the requirement of specific evaluation when there are no alarm symptoms or signs. Functional abdominal pain is categorized as functional dyspepsia, irritable bowel syndrome, functional abdominal pain, abdominal migraine,...
Clinical Lecture
Approach to the Children with Recurrent Infections
Jae Ho Lee
Clin Exp Pediatr. 2005;48(5):461-468.   Published online May 15, 2005
The major function of immune system is to protect infections. The immune systems are composed of innate and adaptive immunity. In adaptive immunity, the cellular and humoral components interact each other. Neonates and infants are infected frequently, because immune systems are naive and easy to expose to infectious agents. The complete history and physical examination is essential to evaluate the...
Original Article
The Significance of Serologic Allergy Tests in Children with Recurrent Pneumonia
Yoon Hee Sim, Sin Weon Yun, Soo Ahn Chae, Dong Keun Lee
Clin Exp Pediatr. 2004;47(6):634-640.   Published online June 15, 2004
Purpose : Pneumonia is one of the most common respiratory diseases in hospitalized children, and often recurs. It has been reported that asthma is one of the significant contributing factors to recurrent pneumonia. On the basis of similarities between asthma and recurrent pneumonia, we intended to evaluate the influence of allergy on recurrent pneumonia. Methods : Seventy one children with...
Etiologic Diagnosis and Clinical Characteristics of Chronic Recurrent Chest Pain in Children
Eun-Jung Choi, Eun-A Lee, Chang-Woo Lee, Du-Young Choi, Yeon-Geun Oh, Jong-Duk Kim, Hyang-Suk Yoon
Clin Exp Pediatr. 2004;47(6):628-633.   Published online June 15, 2004
Purpose : To identify the causes and clinical characteristics, and the efficacy of various diagnostic approaches, we studied, prospectively, pediatric patients with chronic recurrent chest pain. Methods : A prospective study of 122 patients with chronic recurrent chest pain from June 1998 to June 2003 was performed. The male and female ratio was 81 : 41, age 9.3?.1 year. A...
Therapeutic Effect of Helicobacter pylori Eradication in Children with Recurrent Abdominal Pain Associated with H. pylori
Ji Hyun Uhm, Ki Sup Chung
Clin Exp Pediatr. 2004;47(5):547-554.   Published online May 15, 2004
Purpose : In order to clarify the role of Helicobacter pylori(H. pylori) in recurrent abdominal pain, we investigated prospectively the effect of eradication of H. pylori based on symptom improvement in children with recurrent abdominal pain. Methods : Children with recurrent abdominal pain were evaluated with diagnostic upper gastrointestinal endoscopy to rule out peptic ulcer disease, etc. During endoscopy, biopsies were...
Recurrence and Follow-up after Urinary Tract Infection
Ji Hee Kim, Hye Kyung Shin, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 2003;46(6):561-565.   Published online June 15, 2003
Purpose : Urinary tract infection(UTI) is the most common bacterial infectious disease that may induce severe renal injury unless early diagnosis and appropriate treatment are performed. If recurrent UTI is prevented, renal injury can be also reduced. Therefore, we studied the risk factors of recurrent UTI in children. Methods : We performed a retrospective study of 168 children(58 girls and 110...
Recurrence Rate of Febrile Seizures by Combining Risk Factors
Su Jung Moon, Gu Ken Sun, Eun Young Kim, Kyong Hee Na, Sun Young Park, Kyoung Sim Kim, Yong Wook Kim
Clin Exp Pediatr. 2002;45(11):1403-1410.   Published online November 15, 2002
Purpose : In previous studies, various risk factors for recurrent febrile seizures have been identified. But none of these risk factors alone could sufficiently discriminate children at high or low risk for recurrent seizures. Therefore, we tried to identify patients at high risk of recurrent febrile seizures by combining risk factors. Methods : Two hundred and four children who had...
Case Report
A Case of Alport Syndrome Associated with Diffuse Esophageal Leiomyomatosis
Jin Young Jung, Cheol-Min Kim, Yean Jung Lim, Ja Hyung Kim, Chong Woo You, Bo-Hwa Choi, Soo-Joung Hong, Young Seo Park
Clin Exp Pediatr. 2002;45(9):1160-1164.   Published online September 15, 2002
University of Ulsan, Seoul, Korea We report a case of Alport syndrome associated with esophageal leiomyomatosis, presenting as recurrent pneumonia. A 5-year old girl who had a history of cataract visited the out patient clinic with a complaint of recurrent wheezing and respiratory difficulty which had started five months previously. Chest magnetic resonance image(MRI) and esophagography, checked on the suspicion of...
A Case of Vascular Ring Associated with Tracheitis Due to Type b Haemophilus influenzae
Su Hyun Kim, Yoon Sook Chung, Sung Hee Oh, Nam Su Kim, Hyuck Kim
Clin Exp Pediatr. 2002;45(2):261-266.   Published online February 15, 2002
Vascular ring, originating from abnormal regression of the aortic arch during fetal life, can cause prolonged and recurrent respiratory symptoms and dysphagia when the diagnosis is delayed. We report a 4 month old girl with vascular ring, who had been treated for persistent respiratory symptoms including stridor, wheezing, and dyspnea soon after birth. Initially her respiratory symptoms were thought to...
Original Article
Prevalence and Epidemiologic Charicteristics of Chronic Recurrent Headache in Primary School Children
Young-Il Rho, Young-Bong Park, Eun Seok Yang, Sang Kee Park, Eun Youngn Kim, Jong Park, Kyung-Rye Moon
Clin Exp Pediatr. 2001;44(2):119-126.   Published online February 15, 2001
Purpose : The purpose of the study was to determine the prevalence of chronic recurrent headache and the factors associated with it among primary school children. Methods : The survey was performed by a special questionnaire on one thousand and eleven children in grades 4 to 6 at primary schools from 1 to 30 June 1999 in Gwangju city. Results : Prevalence...
Red Blood Cell Indices, Serum Iron and Total Iron Binding Capacity in Children with Helicobacter pylori Infection
Soo Joon Park, Chang Han Lee, Ki Sup Chung
Clin Exp Pediatr. 2000;43(6):755-762.   Published online June 15, 2000
Purpose : H. pylori infection was recently reported to be associated with unexplained iron-deficiency anemia(IDA) in children and adolescents. H. pylori-related IDA was thought to occur due to GI blood loss, scavenging of iron by H. pylori and iron malabsorption. The aim of this study was to examine how the status of H. pylori infection and age of children affected...
Clinical Study of Recurrent Parotitis in Children
Sam-Hwa Yim, Kye-Nam Yoon, Kyung-Yil Lee, Sang-Won Cha, Dong-Jun Lee, Ji-Whan Han, Jin-Han Kang, Kyung-Tai Whang
Clin Exp Pediatr. 2000;43(5):619-624.   Published online May 15, 2000
Purpose : Recurrent parotitis is defined as a recurrent parotid inflammation, generally associated with sialectasis of the parotid gland. It can often be misdiagnosed as recurrent mumps. We studied the clinical and laboratory features of recurrent parotitis. Methods : Outpatient clinical records of 23 cases were analyzed retrospectively between April 1993 and March 1999. Follow-up after the last outpatient clinic...
Relationship of Recurrent Abdominal Pain Syndrome and Gastric Emptying Time
Eui Jun Yang, Jae Hong Park, In Ju Kim
Clin Exp Pediatr. 1998;41(11):1538-1548.   Published online November 15, 1998
Purpose : Recurrent abdominal pain syndrome(RAPS) is not uncommon in school-aged children, but the etiology and pathogenesis are not understood well. But recent studies suggest that motility disorder makes up a majority of the pathogenesis. The aim of this study was to investigate gastric emptying time(GET) which is a method to evaluate gastrointestinal motility in patients with recurrent abdominal pain...
Colonic Transit Time in Children with Recurrent Abdominal Pain
Je Woo Kim, Ki Sup Chung
Clin Exp Pediatr. 1997;40(11):1544-1551.   Published online November 15, 1997
Purpose : Recurrent abdominal pain is defined as the presence of at least three discrete episodes of pain occurring over a period of 3 or more months. The reported prevalence is high up to 15% of school aged children. Mostly the pain results from functional dysmotility of the intestine but not much studies has been done. Thus we studied segmental colonic transit time(CTT)...
Case Report
Ectopic Pancreas of Stomach in a Child with Recurrent Abdominal Pain
Hyun Chul Bae, Je Woo Kim, Ki Sup Chung, Dong Hwan Shin
Clin Exp Pediatr. 1997;40(8):1178-1182.   Published online August 15, 1997
Ectopic pancreas is a rare congenital anomaly defined by the presence of pancreatic tissue that lacks anatomic and vascular continuity with the main body of the pancreas. A 11-year-old girl was admitted to the Department of Pediatrics, Yonsei University College of Medicine with the history of recurrent abdominal pain for 2 years. We performed fiberoptic endoscopy which showed a 1.5¡¿1.5cm sized polypoid mass, and...
Original Article
Clinical Manifestations of Recurrent Abdominal Pain May Differ with Helicobacter pylori Infection in Children
Nam Seon Beck, I-Seok Kang
Clin Exp Pediatr. 1997;40(7):965-973.   Published online July 15, 1997
Purpose : The role of H. pylori in the pathogenesis of recurrent abdominal pain in children is uncertain. In order to find a correlation between H. pylori infection and recurrent abdominal pain in children, the present study was designed to compare the clinical manifestations between recurrent abdominal pain children with and without H. pylori infection and to investigate the effects of H. pylori eradication...
Recurrent Abdominal Pains:A Field Survey of 1,783 School Children in Seoul
Yong Hwan Cho, Byung Duk Seo, Yong Joo Kim, Nam Su Kim, Hahng Lee
Clin Exp Pediatr. 1997;40(2):199-208.   Published online February 15, 1997
Purpose : We investigated the occurrence rate of recurrent abdominal pain(RAP) in general population of elementary school children, accompanied symptoms, symptomaggravating factors such as emotional stresses, food and personality characters, which time of day the pain develops and whether they visited hospital for RAP. Methods : From 1995. 4. 27. to 1995. 5. 12. questionnaires were given to the parents of 1,783...
Serum EosinophilCationic Protein Levelsin Patients with Recurrent Croup
Moon Kil Bahng, Do Yoon Lee, Mee Kyung Namgoong, Jong Soo Kim
Clin Exp Pediatr. 1997;40(2):194-198.   Published online February 15, 1997
Purpose : Most patients suffer from croup only once in a life time. However, a small group of patients suffer from it several times. A type of croup from which they suffer more than 3 times is called recurrent croup. The cause of recurrent croup has not been clearly described, but in recent years the allergic reaction is considered as a...
Evaluation of Chromosomal Analyses done on the Parents with Chromosomal Anomalous Children and Recurrent Abortion
Kyoung Sim Kim, Kibok Kim, Won Jin Kee
Clin Exp Pediatr. 1996;39(9):1216-1223.   Published online September 15, 1996
Purpose : To gather reference data for better genetic counseling, we have evaluated the outcomes of chromosomal analyses performed on the parents with chromosomal anomalous children and recurrent abortion in this hospital for the last 20 years. Methods : Subjected to study were 108 parents (50 fathers & 58 mothers) who had children with Down syndrome, other chromosomal and congenital anomalies, and those who...
Case Report
A Case of Chronic Recurrent Multifocal Osteomyelitis
Weon Young Lee, Eell Ryoo, Mi Jin Jeong, Kye Hwan Seol, Kil Hyen Kim, Hak Su Lee
Clin Exp Pediatr. 1996;39(5):732-737.   Published online May 15, 1996
Chronic recurrent multifocal osteomyelitis(CRMO) is an unusual inflammatory process involving multiple osseous sites. No causative agent can be consistently isolated from these lesions despite multiple biopsies and the affected child purses a clinical course of chronic remissions and exacerbations independent of antibiotic therapy. Biopsy of the lesions did not reveal any pathogens. Immunologic investigation revealed no abnormality common to the patient...
Original Article
A Clinical Evaluation of the Gastrofiberscopy Studies in Children
Jung Ah Park, Young Ho Ahn, Jin Bok Hwang, Chang Ho Han, Hai Lee Chung, Young Dae Kwon, Jae Bok Park
Clin Exp Pediatr. 1995;38(11):1498-1505.   Published online November 15, 1995
Purpose : This study aimed to provide, as basic material, the experience of gastrofiberscopy in children and the clinical significance of Helicobacter pylori(H. pylori) infection in pediatric gastrointestinal disease. Methods : The objects were 99 patients(male 49, female 50) who underwent gastrofiberscopic examination in case of endoscopic indication at department of pediatrics of Taegu Hyosung Catholic University Hospital from March 1993...
Recurrent Abdominal Pain in Children: Endoscopic Findings and Helicobacter pylori Infection
Cheol Ho Chang, Churl Young Chung
Clin Exp Pediatr. 1995;38(1):47-53.   Published online January 15, 1995
Purpose : Recurrent abdominal pain (RAP) in children is similar to nonulcer dyspepsia of adult. Recently, microscopic inflammation and Helicobacter pylori (H. pylori) infection have been suggested as possible causes of nonulcer dyspepsia in adults. The aim was to know the clinical significance of encoscopic findings and H. pylori infection in children with RAP. Methods : 128 children with RAP underwent...
A Clinical and Pathological Study of Recurrent Hematuria in Childhood
Mi Jeong Kim, Jae Wook Ko, Young Jin Hong, Myung Ik Lee, Sun Wha Kim, Don Hee Ahn
Clin Exp Pediatr. 1994;37(8):1104-1110.   Published online August 15, 1994
The clinico-pathological observation was done on 28 children with recurrent hematuria, who had been admitted to the Pediatric ward of NMC from January 1981 to July 1991. The results were as follows; 1) Most of the children with recurrent hematuria were over 6 years of age (24 cases, 85.7%) and the sex ratio was about 2.5:1. 2) IgA nephropathy (17 cases, 60.7%) was...
Case Report
Recurrent Rhinocerebral Mucormycosis - A Case Report
Ho Sung Kim, Jin Young Park, Bo Young Yun, Eun Sil Dong, Hee Young Shin, Hoan Jong Lee, Hyo Seop Ahn, Je Geun Chi, Myung Whun Sung
Clin Exp Pediatr. 1993;36(4):589-595.   Published online April 15, 1993
A case of recurrent rhinocerebral mucormycosis that has occurred during an induction chemotherapy for acute megakaryocytic leukemia in a 10 year-old boy is reported. He had suffered from high fever, proptosis, right eye ball pain and necrotic inflammation of hard palate during the chemotherapy of leukemia. CT scan of the paranasal sinus showed inflammatory change of right ethmoid and maxillary...
A Case of Wiskott-Aldrich Syndrome
Dong Un Kim, Seung Hoon Han, Jin Han Kang, Joon Sung Lee
Clin Exp Pediatr. 1993;36(3):439-446.   Published online March 15, 1993
Wiskott-Aldrich syndrome s an X-linked combined immunodeficency disorder characterzed by severely decreased number of platelets which are small in size, eczema resembling atopic dermatitis and recurrent infection. The serum of the patient contains elevated concentrations of IgA and IgE, whereas the IgG level is usually normal and IgM level is deecreased. The patient also shows skin test anergy and progressive...
Original Article
Urinary Vitamin C Loading Test and Therapeutic Effect of Vitamin C in Children with Idiopathic Recurrent Epistaxis
In Soon Park, Woo Yeong Chung, Soon Yong Lee
Clin Exp Pediatr. 1993;36(2):266-272.   Published online February 15, 1993
Recurrent epistaxis is not one of rare symptoms in children, the well-known causes of which are anatomical abnormalities of nasal cavity and systemic bleeding tendency. But, in the majority of cases of recurrent epistasix, it is usually very difficult to find out their underlying causes, so that the treatment is only symptomatic control of nasal bleeding whenever epistaxis occurs, but...
Gastrofiberscopic Findings and Helicobacter pylori Gastritis in Children with Recurrent Abdominal Pain
Jeong Kee Seo, Je Geun Chi, Eui Chong Kim
Clin Exp Pediatr. 1992;35(12):1646-1656.   Published online December 15, 1992
Gastrofiberscopic findings and the presence of Helicobacter pylori (H. pylori) were studied prospectively in children with recurrent abdominal pain (RAP). Endoscopic findings in 707 children with RAP revealed that 243 children (34.3%) showed abnormal findings including gastritis in 16.9%, duodenitis in 10.4%, esophagitis in 5.7%, duodenal ulcer in 5.7%, and gastric ulcer in 1.1% of children with RAP. Endoscopic biopsy of...
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