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- Original Article
- Gastroenterology
- Influence of proton pump inhibitor therapy on intestinal inflammation assessed by fecal calprotectin in pediatric patients
- Su Yeong Kim, Na Mi Lee, Sin Weon Yun, Soo Ahn Chae, In Seok Lim, Eung Sang Choi, Dae Yong Yi
- Clin Exp Pediatr. 2019;62(10):400-404. Published online July 3, 2019
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Background: An increase in the numbers of patients with gastrointestinal symptoms has recently been observed.
Purpose: To investigate the effects of proton pump inhibitor (PPI) therapy on intestinal inflammation in children and adolescents as confirmed by clinical manifestations and objectively assessed by fecal calprotectin (FC) level measurement. Methods: Consecutive children (aged 3–18 years) who presented with gastrointestinal symptoms and were treated with...
- Infection
- Uropathogenic
Escherichia coli ST131 in urinary tract infections in children - Ki Wook Yun, Mi-Kyung Lee, Wonyong Kim, In Seok Lim
- Clin Exp Pediatr. 2017;60(7):221-226. Published online July 31, 2017
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Purpose Escherichia coli sequence type (ST) 131, a multidrug-resistant clone causing extraintestinal infections, has rapidly become prevalent worldwide. However, the epidemiological and clinical features of pediatric infections are poorly understood. We aimed to explore the characteristics of ST131Escherichia coli isolated from Korean children with urinary tract infections.Methods We examined 114 uropathogenic
E. coli (UPEC) isolates from children hospitalized at Chung-Ang University...
- Usefulness of interferon-γ release assay for the diagnosis of latent tuberculosis infection in young children
- Ki Wook Yun, Young Kwang Kim, Hae Ryun Kim, Mi Kyung Lee, In Seok Lim
- Clin Exp Pediatr. 2016;59(6):256-261. Published online June 30, 2016
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Purpose Latent tuberculosis infection (LTBI) in young children may progress to severe active tuberculosis (TB) disease and serve as a reservoir for future transmission of TB disease. There are limited data on interferon-γ release assay (IGRA) performance in young children, which our research aims to address by investigating the usefulness of IGRA for the diagnosis of LTBI.
Methods We performed a tuberculin skin...
- Molecular typing of uropathogenic
Escherichia coli isolated from Korean children with urinary tract infection - Ki Wook Yun, Do Soo Kim, Wonyong Kim, In Seok Lim
- Clin Exp Pediatr. 2015;58(1):20-27. Published online January 31, 2015
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Purpose We investigated the molecular types of uropathogenic
Escherichia coli (UPEC) by using conventional phylogrouping, multilocus sequence typing (MLST), andfimH genotyping.Methods Samples of patients younger than 18 years of age were collected from the Chung-Ang University Hospital over 2 years. Conventional phylogenetic grouping for UPEC strains was performed by polymerase chain reaction (PCR). Bacterial strain sequence types (STs) were classified on...
- Correlation between glomerular filtration rate and urinary N acetyl-beta-D glucosaminidase in children with persistent proteinuria in chronic glomerular disease
- Jeong Deok Hong, In Seok Lim
- Clin Exp Pediatr. 2012;55(4):136-142. Published online April 30, 2012
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Purpose Urinary excretion of N acetyl-beta-D glucosaminidase (NAG) and β2-microglobulin (β2-M) was increased in the presence of proximal tubular damage. Based on these urinary materials, we investigated the ability of expecting renal function in chronic glomerular diseases. In this study, we evaluated the relationship between glomerular filtration rate (GFR) urinary NAG, and urinary β2-M.
Methods We evaluated 52 children with chronic kidney disease...
- Clinical significance of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 and 2 in Kawasaki disease
- Ki Wook Yun, Sin Weon Sin, Jung Ju Lee, Soo Ahn Chae, In Seok Lim, Eung Sang Choi, Byoung Hoon Yoo, Mi-Kyung Lee
- Clin Exp Pediatr. 2010;53(4):510-518. Published online April 15, 2010
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Purpose : Kawasaki disease (KD) is a systemic vasculitis, a leading cause of pediatric acquired heart disease. Histopathological findings of coronary artery lesion (CAL) in KD indicate destruction of the coronary artery wall with diffuse vasculitis. Matrix metalloproteinases (MMPs) and their endogenous tissue inhibitors (TIMPs) might play central roles in this process. Special attention to MMP-9 has recently been emerging.... -
- Comparison of various methods of glomerular filtration rate measurements in children
- Na Mi Lee, In Seok Lim
- Clin Exp Pediatr. 2009;52(9):999-1004. Published online September 15, 2009
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Purpose:Glomerular filtration rate (GFR) is a fundamental parameter in assessing renal function and predicting the progression of chronic renal disease. Because the use of serum creatinine has several disadvantages, many studies have investigated the use of cystatin C for estimating GFR. We compared creatinine clearance and GFR with formulas using serum creatinine and cystatin C. Methods:We retrospectively analyzed 211 patients... -
- Factors affecting the contamination of bag urine culture in febrile children under two years
- Wook Hyun Choi, In Seok Lim
- Clin Exp Pediatr. 2009;52(3):346-350. Published online March 15, 2009
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Purpose : Since children under two years with suspected urinary tract infections (UTIs) cannot control urination, urine cultures in such children are usually performed via urine bags. This method is noninvasive but has a high contamination rate. We studied the contamination rate of bag urine culture in diagnosing UTI in infants under two years and the factors responsible for contamination. Methods... -
- Epidemiologic and clinical features in children with acute lower respiratory tract infection caused by human metapneumovirus in 2006-2007
- Gwi Ok Park, Ji Hyun Kim, Jae Hee Lee, Jung Ju Lee, Sin Weon Yun, In Seok Lim, Dong Keun Lee, Eung Sang Choi, Byoung Hoon Yoo,, Mi Kyung Lee, Soo Ahn Chae
- Clin Exp Pediatr. 2009;52(3):330-338. Published online March 15, 2009
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Purpose : The causes of acute lower respiratory tract infection (ALRTI) are mostly attributable to viral infection, including respiratory syncytial virus (RSV), parainfluenza virus (PIV), influenza virus A/B (IFV A/B), or adenovirus (ADV). Several Korean studies reported human metapneumovirus (hMPV) as a common pathogen of ALRTI. However, studies on seasonal distribution and clinical differences relative to other viruses are insufficient,... -
- Case Report
- A case of herpes zoster in a 4-month-old infant
- Ji Hyun Kim, Jung Ju Lee, Sin Weon Yun, Soo Ahn Chae, In Seok Lim, Dong Keun Lee, Eung Sang Choi, Byoung Hoon Yoo
- Clin Exp Pediatr. 2008;51(12):1368-1371. Published online December 15, 2008
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Herpes zoster in infancy is very rare but can be developed following intrauterine or postnatal exposure to varicella zoster virus. We report a case of herpes zoster in a 4-month-old male infant. He had no prior history of primary varicella or varicella vaccination. His mother had no history of varicella infection and no contact history with varicella during pregnancy. He... -
- Original Article
- Clinical significance of serum vascular endothelial growth factor in Kawasaki disease
- Ho Seok Lee, Sin Weon Yun, Young Soo Jung, Soo Ahn Chae, In Seok Lim, Dong Keun Lee, Eung Sang Choi, Byung Hoon Yoo, Mi Kyung Lee
- Clin Exp Pediatr. 2007;50(10):995-1004. Published online October 15, 2007
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Purpose : Kawasaki disease is a systemic vasculitis, leading cause of pediatric acquired heart disease. Vascular endothelial growth factor (VEGF) has functions as vascular permeability factor, plays an important role in coronary artery lesion (CAL). We studied the clinical significance of serum VEGF in Kawasaki disease. Methods : Kawasaki group was 49 patients, and control group was 15 patients. Diagnosis followed... -
- Analysis of urine β2-microglobulin in pediatric renal disease
- Dong Woon Kim, In Seok Lim
- Clin Exp Pediatr. 2007;50(4):369-375. Published online April 15, 2007
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Purpose : There have been numerous researches on urine β2-microglobulin (β2-M) concerned with primary nephrotic syndrome and other glomerular diseases, but not much has been done in relation to pediatric age groups. Thus, our hospital decided to study the relations between the analysis of the test results we have conducted on pediatric patients and renal functions. Methods : Retrospective data... -
- Therapeutic Effect of Anti-Rotavirus Chicken Egg Yolk Immunoglobulin(IgY) on Diarrhea by Infection of Rotavirus
- In Seok Lim, Ho Seok Lee, Wonyong Kim, Eung Sang Choi, Dong Hyuk Jung, Hoo Kil Jung, Sung Seob Yun, Ho Nam Chun
- Clin Exp Pediatr. 2005;48(12):1354-1361. Published online December 15, 2005
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Purpose : Rotavirus is an enteric pathogen that affects millions of children globally each year. But no specific therapy is available for the management of rotavirus diarrhea. Due to the clear need to define improved modality for treatment of rotavirus diarrhea, we evaluated the efficacy of anti- rotavirus IgY in the treatment of infants and children with gastroenteritis. Methods : First,... -
- Relationship between the Body Fat Mass Measured by Bioelectrical Impedance Analysis(BIA) and Dual Energy X-ray Absorptiometry(DEXA), and by the Indices of Insulin Sensitivity
- In Seok Lim, Ki Wook Yun
- Clin Exp Pediatr. 2005;48(8):857-864. Published online August 15, 2005
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Purpose : The objectives of this study was to evaluate the correlations between the indices of insulin sensitivity using fasting glucose and insulin level, and the body fat mass measured by bioelectrical impedance analysis(BIA) and dual energy X-ray absorptiometry(DEXA), and to determine the clinical usefulness of insulin sensitivity indices when obese children were followed up. Methods : In this study, 28... -
- A Study for Accuracy and Usefulness of Tympanic Membrane and Forehead Thermometers
- Ki Wook Yun, In Seok Lim
- Clin Exp Pediatr. 2005;48(8):820-825. Published online August 15, 2005
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Purpose : The presence and degree of fever in children is a useful indicator of illness. This project aimed to assess the accuracy and usefulness of infrared tympanic membrane(TM) & forehead feverscan thermometers for measuring children's temperatures. Methods : Data were obtained from 1,050 children with a median age of 4.5 years. They visited the pediatric clinics at Chung-Ang University Yongsan... -
- Clinical Lecture
- About the Reformed Medical Terms
- In Seok Lim
- Clin Exp Pediatr. 2004;47(7):716-718. Published online July 15, 2004
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Concerning our medical history, the importance of medical terms has been neglected for a long time. In addition, medical terminologies are unaccustomed to the patients including the public. The separation of communications between the public and medical participants has been enlarged more and more. The importance of terms which can be easily recognized, comfortable to the ear, and familiar to... -
- Original Article
- Correlation of Measurements for Body Fat in Obese Children
- Jong Hoon Kim, In Seok Lim
- Clin Exp Pediatr. 2004;47(5):485-490. Published online May 15, 2004
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Purpose : Measurement of body fat in obese children is useful not only in evaluating health hazard but also in establishing standards of treatment and evaluating the effectiveness of treatment. In the field of clinical and laboratory study, there are various methods with different reliability, propriety, convenience, and expenses. However, the practical value of these studies is limited in Korea,... -
- Case Report
- A Case of Teratocarcinoma with Central Diabetes Insipidus
- Jong Hoon Kim, In Seok Lim, Eung Sang Choi, Byoung Hoon Yoo
- Clin Exp Pediatr. 2004;47(4):453-457. Published online April 15, 2004
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Central diabetes insipidus is a rare disorder that can result as a consequence of diverse etiologies, including malformations, autoimmune, infiltrative(e.g. neoplastic or histiocytosis) or traumatic processes, as well as mutations in the gene encoding arginine vasopressin. Idiopathic central diabetes insipidus is a diagnosis of exclusion, one that has been made less frequently through the decades. Idiopathic central diabetes insipidus in... -
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- A Case of Primitive Neuroectodermal Tumor of the Adrenal Gland
- Sun Pil Jung, Chong Gwon Oh, In Seok Lim, Dong Keun Lee, Byoung Hoon Yoo
- Clin Exp Pediatr. 2001;44(12):1459-1462. Published online December 15, 2001
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Primitive neuroectodermal tumors(PNETs) are a group of small round cell tumors that may arise in the central or peripheral nervous system. In the extracranial location, these neoplasms may occur anywhere and at any age group, but most likely in the bone and soft tissue of children and young adults. The incidence of adrenal gland involvement is very rare. This tumor... -
- Original Article
- Factors Predictive of Response to Interferon-α Therapy in Children with Chronic Hepatitis B
- Hong Kwon Kim, Bo Hwa Choi, Kyung Mo Kim, Kyung Hoon Kang, In Seok Lim, Eung Sang Choi
- Clin Exp Pediatr. 2000;43(4):514-519. Published online April 15, 2000
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Purpose : The efficacy and safety of interferon-alpha(IFN-α) therapy in children with chronic hepatitis B(CHB) is similar to that of adults. However, little information is available about the predictive factors of response to this therapy in children. The aim of this study was to determine the predictive factors for responsiveness to IFN-α therapy in children with CHB. Methods : The basal... -
- Clinical Significance of Serum ECP in Mycoplasma Pneumoniae Pneumonia
- Young Ghil Rah, Dong Keun Lee, In Seok Lim, Eung Sang Choi, Soo Ahn Chae
- Clin Exp Pediatr. 1999;42(5):672-678. Published online May 15, 1999
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Purpose : Allergic inflammation of the lower respiratory tract is a characteristic clinical feature in asthma patients, in which eosinophils play an important role. The activity of eosinophil may be determined by measuring the level of eosinophil cationic protein(ECP) in sputum or serum as a potential marker of the inflammatory severity. Methods : We measured the serum concentrations of ECP... -
- Interaction of the mec Regulator Genes in Methicillin Resistant Staphylococcus
- Young Choi, In Seok Lim, Tae Sub Shim, Mi Kyung Lee, Ae Ja Park
- Clin Exp Pediatr. 1998;41(9):1224-1233. Published online September 15, 1998
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Purpose : Low-affinity penicillin-binding protein PBP 2a encoded by mecA is closely related to methicillin resistance in staphylococci, and the expression of PBP 2a is controlled by regulator elements encoded by mecR1 and mecI. Deletion or mutation which occurred in mecI is considered to be associated with constitutive production of PBP 2a. We investigated the distribution of mec regulator genes... -
- Prediction of Steroid Responsiveness in the Primary Nephrotic Syndrome Using Urinary β2-Microglobulin Level and N-Acetyl-β-D-Glucosaminidase Activity
- Kwang In Lee, In Seok Lim, Eung Sang Choi
- Clin Exp Pediatr. 1997;40(9):1285-1292. Published online September 15, 1997
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Purpose : Considering that renal biopsy is not routinely indicated in nephrotic syndrome in children and the risk of the procedure, we studied that it is possible to predict steroid responsiveness in nephrotic syndrome and the difference in responsivenss is related with the histopathologic type using urinary β2-microglobulin and N-Acetyl-β-D-Glucosaminidase activity as a safe and noninvasive method. Methods : We measured serum creatinine, albumin, cholesterol... -
- Case Report
- A Case of Idiopathic Long QT Syndrome with 2:1 Atrioventricular Block
- Kwang In Lee, Chul Ha Kim, In Seok Lim, Dong Keun Lee, Byoung Hoon Yoo
- Clin Exp Pediatr. 1995;38(12):1701-1705. Published online December 15, 1995
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The idiopathic long QT syndrome is a very rare disorder in which affected individuals have an unusual electrocardiographic repolarization abnormality (QT prolongation) and a propensity to syncope and fatal ventricular arrhythmia. Since Jervell and Lange-Nielsen first described this syndrome in 1957, progression has been made in the pathophysiology and in the treatment. Sinus bradycardia may be associated with this syndrome sometimes,... -
- Pseudoaneurysm after Renal Biopsy; Angigraphic Diagnosis and Treatment by Superselective Embolization
- Sin Weon Yun, Keun Seop Jung, In Seok Lim, Chul Ha Kim, Dong Keun Lee, Byeong Heun You, Hyung Jin Shim, Young Ku Kim
- Clin Exp Pediatr. 1995;38(3):417-421. Published online March 15, 1995
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The use of superselective embolization was assessed as a treatment for bleeding from arteriovenous fistulas and pseudoaneurysm after renal biopsy procedure. But unless it is sufficiently selective, the procedure results in loss of significant amount of renal parenchyme. We experienced one case of renal arterial pseudoaneurysm, which happened at 5days after percutaneous renal biopsy. Diagnosis of pseudoaneurysm was made by... -
- A Case of Nasopharyngeal Teratoma Showing Upper Airway Obstruction
- Jeong Ho Jeon, In Seok Lim, Chul Hwa Kim, Byeng Hoon Yoo
- Clin Exp Pediatr. 1994;37(4):560-564. Published online April 15, 1994
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Neoplasms of the nasophrynx are rare in neonates and infants. The most common nasopharyngeal tumor encountered in this age group is teratoma-neoplasm containing multiple heterotopic tissues. Four histologic types of nasopharyngeal teratoma occur-dermoid, teratoid, true teratoma, epignathing of which dermoid is most frequently seen. We have experienced a case of nasopharyngeal teratoma in a female neonate with signs and symptoms of... -
- Original Article
- Clinical analysis of Serum and Urine N-Acetyl-β-D-Glucosaminidase (NAG) in Renal Disease
- Yo Han Chung, In Seok Lim, Chul Ha Kim, Byoung Hoon Yoo, Tae Sub Shim
- Clin Exp Pediatr. 1994;37(3):383-389. Published online March 15, 1994
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Recently, NAG activity has gained increasing importance as an aid in the diagnosis of renoparenchymal diseases. Elevation of urine NAG activity has been found to be an indicator of renoparenchymal diseases. To evaluate the diagnostic value of the NAG activity test in the renal disease, we carried out clinical study on 31 cases of renal disease patients who had been... -
- Case Report
- A Case of Roberts Syndrome
- Young Choi, Yo Han Chung, In Seok Lim, Chul Ha Kim, Dong Keun Lee, Seong Nam Kim, Sang Yong Song, Je Geun Chi
- Clin Exp Pediatr. 1993;36(10):1447-1451. Published online October 15, 1993
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Roberts syndrome is an autosomal recessive disorder accompanied by limb defects, craniofacial abnormalities, pre-and postnatal growth retardation. Patients with Roberts syndrome have characteristic premature separation of heterochromatin of many chromosomes and abnormalties in celldivision cycle. We have experienced a case of Roberts syndrome in an immature neonate. The patients showed characteristic clinical features of multiple encephaloceles. Severe facial mid-line clefts, and... -
- A Case of Fanconi Syndrome
- Young Woon Lee, In Seok Lim, Chul Ha Kim
- Clin Exp Pediatr. 1993;36(5):737-442. Published online May 15, 1993
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Fanconi syndrome is a complex of renal tubular dysfunction defined by glycosuria without diabetes, generalized aminoaciduria, phosphaturia, bicarbonaturia, uric aciduria, and renal tubular acidosis. It is often associated with hypokalemia, hypophosphatemia, rickets and osteomalacia. We have experienced one case of Fanconi syndrome with chronic tubulointerstitial nephritis. The patient was a 4 year and boy and his chief complaints were polyruia, polydipsia,... -
- Original Article
- A case of malignant atrophic papulosis (Degos' disease).
- Sung Ku Lee, In Seok Lim, Chul Ha Kim, Dong Keun Lee, Eung Sang Choi, Byoung Hoon Yoo, Gae Yong Song
- Clin Exp Pediatr. 1991;34(12):1724-1729. Published online December 31, 1991
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Malignant atrophic papulosis (Degos’ disease) is characterized by porcelain-white skin lesions. It has unknown etiology and bad prognosis. Death usually occurs from multiple intestinal perforations weeks to years after onset. We experienced a case of Degos’ disease in a 12-year-old male patient who had porcelain white papules on face, trunk and extremities. Histopathologic studies showed broad epidermal necrobiosis with thrombotic arteriolar occlusion. A brief review of... -
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6.52022CiteScore92nd percentilePowered by
